VIPoma: Difference between revisions

	WikiDoc Resources for VIPoma
Articles
Most recent articles on VIPoma Most cited articles on VIPoma Review articles on VIPoma Articles on VIPoma in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on VIPoma Images of VIPoma Photos of VIPoma Podcasts & MP3s on VIPoma Videos on VIPoma
Evidence Based Medicine
Cochrane Collaboration on VIPoma Bandolier on VIPoma TRIP on VIPoma
Clinical Trials
Ongoing Trials on VIPoma at Clinical Trials.gov Trial results on VIPoma Clinical Trials on VIPoma at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on VIPoma NICE Guidance on VIPoma NHS PRODIGY Guidance FDA on VIPoma CDC on VIPoma
Books
Books on VIPoma
News
VIPoma in the news Be alerted to news on VIPoma News trends on VIPoma
Commentary
Blogs on VIPoma
Definitions
Definitions of VIPoma
Patient Resources / Community
Patient resources on VIPoma Discussion groups on VIPoma Patient Handouts on VIPoma Directions to Hospitals Treating VIPoma Risk calculators and risk factors for VIPoma
Healthcare Provider Resources
Symptoms of VIPoma Causes & Risk Factors for VIPoma Diagnostic studies for VIPoma Treatment of VIPoma
Continuing Medical Education (CME)
CME Programs on VIPoma
International
VIPoma en Espanol VIPoma en Francais
Business
VIPoma in the Marketplace Patents on VIPoma
Experimental / Informatics
List of terms related to VIPoma

	VIPoma;
	Pancreatic vipoma. Electron microscopy of a pancreatic VIPoma. Abundant secretory granules of variable size, shape, and density in a pancreatic tumor with WDHA syndrome. Abundant PP-and a few VIP-immunoreactive cells (inset) were detected by light microscopic immunohistochemistry of the same tumor (X28.000). ; Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology
ICD-10	C25.4 or E16.8
ICD-O:	8155/3
DiseasesDB	13877
MedlinePlus	000228
MeSH	D003969

VisualWikitext

Revision as of 01:00, 19 September 2012

For patient information, click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Watery diarrhea with hypokalemic alkalosis; WDHA syndrome; pancreatic cholera syndrome; Verner-Morrison syndrome.

Overview

Historical Perspective

Pathophysiology

Causes

Differentiating VIPoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Other Diagnostic Studies

Treatment

Case Studies

Case #1

de:Verner-Morrison-Syndrom

Template:Tumor morphology

Template:WikiDoc Sources

@@ Line 18: / Line 18: @@
 {{SK}} Watery diarrhea with hypokalemic alkalosis; WDHA syndrome; pancreatic cholera syndrome; Verner-Morrison syndrome.
-==Overview==
+==[[VIPoma overview|Overview]]==
-A '''VIPoma''' (also known as '''[[Verner Morrison syndrome]]''', after the physicians who first described it <ref>Verner, J. V., and Morrison, A. B. Islet cell tumor and a syndrome of refractory watery diarrhea and hypokalemia. ''Am J Med'' 1958; '''374''': 1958.</ref>) is a rare (1 per 10'000'000 per year) [[endocrine]] [[tumor]], usually (about 90%) originating in the [[pancreas]], which produces [[vasoactive intestinal peptide]] (VIP).
+==[[VIPoma historical perspective|Historical Perspective]]==
-* A syndrome caused by non-β islet-cell tumors.
+==[[VIPoma pathophysiology|Pathophysiology]]==
-* It may be associated with multiple endocrine neoplasia.
-The massive amounts of VIP in turn cause profound and chronic '''w'''atery '''d'''[[diarrhea|iarrhea]] and resultant  [[dehydration]], '''h'''[[hypokalemia|ypokalemia]], '''a'''[[achlorhydria|chlorhydria]] (hence '''WDHA-syndrome''', or '''pancreatic cholera syndrome'''), acidosis, [[vasodilation]] ([[flushing (physiology)|flushing]] and [[hypotension]]), [[hypercalcemia]] and [[hyperglycemia]].<ref>Mansour JC, Chen H. Pancreatic endocrine tumors. ''J Surg Res'' 2004; '''120''': 139-61. PMID 15172200</ref>
+==[[VIPoma causes|Causes]]==
-==Symptoms and Signs==
+==[[VIPoma differential diagnosis|Differentiating VIPoma from other Diseases]]==
-The Major clinical features are prolonged watery [[diarrhea]] (fasting stool volume > 750 to 1000 mL/day)and symptoms of [[hypokalemia]] and [[dehydration]].
-Half of the patients have relatively constant [[diarrhea]] while the rest have alternating periods of severe and moderate [[diarrhea]].
+==[[VIPoma epidemiology and demographics|Epidemiology and Demographics]]==
-One third have diarrhea < 1yr before diagnosis ,but in 25%, diarrhea is present for 5 yr or more before diagnosis.
-[[Lethargy]], muscle weakness, [[nausea]], vomiting and crampy abdominal pain are frequent symptoms.
+==[[VIPoma risk factors|Risk Factors]]==
-[[Hyperkalemia]] and impaired [[glucose]] tolerance occur in < 50% of patients.
-During attacks of diarrhea, flushing similar to the [[carcinoid syndrome]] occur rarely.
+==[[VIPoma screening|Screening]]==
+==[[VIPoma natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
 ==Diagnosis==
-Besides the clinical picture, [[fasting]] VIP [[blood plasma|plasma]] dosage may confirm the diagnosis, and [[CT scan]] and [[somatostatin]] receptor [[scintigraphy]] are used to localise the [[tumor]], which is usually [[metastasis|metastatic]] at presentation.
+[[VIPoma history and symptoms|History and Symptoms]] | [[VIPoma physical examination|Physical Examination]] | [[VIPoma laboratory findings|Laboratory Findings]] | [[VIPoma x ray|X Ray]] | [[VIPoma CT|CT]] | [[VIPoma MRI|MRI]] | [[VIPoma echocardiography or ultrasound|Echocardiography or Ultrasound]] | [[VIPoma other imaging findings|Other Imaging Findings]] |
+ [[VIPoma other diagnostic studies|Other Diagnostic Studies]]
 ==Treatment==
-Besides treating the [[water]] and [[electrolyte]] abnormalities, [[octreotide]] (a [[somatostatin]] analogue) can be used to temper symptoms. [[Surgery]] is the only curative option.
-==References==
+[[VIPoma medical therapy|Medical Therapy]] | [[VIPoma surgery|Surgery]] | [[VIPoma primary prevention|Primary Prevention]] | [[VIPoma secondary prevention|Secondary Prevention]] | [[VIPoma cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[VIPoma future or investigational therapies|Future or Investigational Therapies]]
-<references/>
-==Additional Resources==
+==Case Studies==
-^The MERCK MANUAL Of Diagnosis And Therapy
+[[VIPoma case study one|Case #1]]
-<br>
 [[Category:Endocrinology]]
 [[Category:Types of cancer]]
+[[Category:Oncology]]
 [[de:Verner-Morrison-Syndrom]]


VIPoma
Pancreatic vipoma. Electron microscopy of a pancreatic VIPoma. Abundant secretory granules of variable size, shape, and density in a pancreatic tumor with WDHA syndrome. Abundant PP-and a few VIP-immunoreactive cells (inset) were detected by light microscopic immunohistochemistry of the same tumor (X28.000). Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology
ICD-10	C25.4 or E16.8
ICD-O:	8155/3
DiseasesDB	13877
MedlinePlus	000228
MeSH	D003969

VIPoma: Difference between revisions

Revision as of 01:00, 19 September 2012

Diagnosis

Treatment

Case Studies

Navigation menu