Type II collagen: Difference between revisions
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|HGNCid=2200 | |HGNCid=2200 | ||
|Symbol=COL2A1 | |Symbol=[[Collagen, type II, alpha 1|COL2A1]] | ||
|AltSymbols=SEDC | |AltSymbols=SEDC | ||
|EntrezGene=1280 | |EntrezGene=1280 | ||
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|LocusSupplementaryData=-q13.2 | |LocusSupplementaryData=-q13.2 | ||
}} | }} | ||
'''Type II [[collagen]]''' is the basis for [[articular cartilage]] and [[hyaline cartilage]]. | '''Type II [[collagen]]''' is the basis for [[articular cartilage]] and [[hyaline cartilage]], formed by [[homotrimer]]s of [[collagen, type II, alpha 1]] chains. | ||
It makes up 50% of all protein in [[cartilage]] and | It makes up 50% of all protein in [[cartilage]] and 85–90% of collagen of articular cartilage. | ||
Type II collagen does form | Type II collagen does form [[fibril]]s. This fibrillar network of collagen allows cartilage to entrap the [[proteoglycan]] aggregate as well as provide tensile strength to the tissue. Oral administration of native type II collagen induces oral tolerance to pathological immune responses and may be useful in arthritis.<ref>{{cite journal | vauthors = Park KS, Park MJ, Cho ML, Kwok SK, Ju JH, Ko HJ, Park SH, Kim HY | title = Type II collagen oral tolerance; mechanism and role in collagen-induced arthritis and rheumatoid arthritis | journal = Modern Rheumatology | volume = 19 | issue = 6 | pages = 581–9 | date = 2009 | pmid = 19697097 | doi = 10.1007/s10165-009-0210-0 }}</ref><ref>{{cite journal | vauthors = Bakilan F, Armagan O, Ozgen M, Tascioglu F, Bolluk O, Alatas O | title = Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial | journal = The Eurasian Journal of Medicine | volume = 48 | issue = 2 | pages = 95–101 | date = June 2016 | pmid = 27551171 | pmc = 4970562 | doi = 10.5152/eurasianjmed.2015.15030 }}</ref> | ||
== See also == | == See also == | ||
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* [[Collagen, type III, alpha 1]] | * [[Collagen, type III, alpha 1]] | ||
==References== | == References == | ||
{{Reflist|colwidth=30em}} | {{Reflist|colwidth=30em}} | ||
==External links== | == External links == | ||
* {{MeshName|Collagen+type+II}} | * {{MeshName|Collagen+type+II}} | ||
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[[Category:Collagens]] | [[Category:Collagens]] | ||
{{gene-12-stub}} | {{gene-12-stub}} | ||
Latest revision as of 15:38, 9 December 2018
| collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital) | |
|---|---|
| Identifiers | |
| Symbol | COL2A1 |
| Alt. symbols | SEDC |
| Entrez | 1280 |
| HUGO | 2200 |
| OMIM | 120140 |
| RefSeq | NM_001844 |
| UniProt | P02458 |
| Other data | |
| Locus | Chr. 12 q13.11-q13.2 |
Type II collagen is the basis for articular cartilage and hyaline cartilage, formed by homotrimers of collagen, type II, alpha 1 chains.
It makes up 50% of all protein in cartilage and 85–90% of collagen of articular cartilage.
Type II collagen does form fibrils. This fibrillar network of collagen allows cartilage to entrap the proteoglycan aggregate as well as provide tensile strength to the tissue. Oral administration of native type II collagen induces oral tolerance to pathological immune responses and may be useful in arthritis.[1][2]
See also
References
- ↑ Park KS, Park MJ, Cho ML, Kwok SK, Ju JH, Ko HJ, Park SH, Kim HY (2009). "Type II collagen oral tolerance; mechanism and role in collagen-induced arthritis and rheumatoid arthritis". Modern Rheumatology. 19 (6): 581–9. doi:10.1007/s10165-009-0210-0. PMID 19697097.
- ↑ Bakilan F, Armagan O, Ozgen M, Tascioglu F, Bolluk O, Alatas O (June 2016). "Effects of Native Type II Collagen Treatment on Knee Osteoarthritis: A Randomized Controlled Trial". The Eurasian Journal of Medicine. 48 (2): 95–101. doi:10.5152/eurasianjmed.2015.15030. PMC 4970562. PMID 27551171.
External links
- Collagen+type+II at the US National Library of Medicine Medical Subject Headings (MeSH)
 | This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it. |