Tumour necrosis factor

Revision as of 17:09, 20 August 2012 by WikiBot (talk | contribs) (Robot: Automated text replacement (-{{SIB}} +, -{{EH}} +, -{{EJ}} +, -{{Editor Help}} +, -{{Editor Join}} +))
(diff) ← Older revision | Latest revision (diff) | Newer revision → (diff)
Jump to navigation Jump to search

WikiDoc Resources for Tumour necrosis factor

Articles

Most recent articles on Tumour necrosis factor

Most cited articles on Tumour necrosis factor

Review articles on Tumour necrosis factor

Articles on Tumour necrosis factor in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Tumour necrosis factor

Images of Tumour necrosis factor

Photos of Tumour necrosis factor

Podcasts & MP3s on Tumour necrosis factor

Videos on Tumour necrosis factor

Evidence Based Medicine

Cochrane Collaboration on Tumour necrosis factor

Bandolier on Tumour necrosis factor

TRIP on Tumour necrosis factor

Clinical Trials

Ongoing Trials on Tumour necrosis factor at Clinical Trials.gov

Trial results on Tumour necrosis factor

Clinical Trials on Tumour necrosis factor at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Tumour necrosis factor

NICE Guidance on Tumour necrosis factor

NHS PRODIGY Guidance

FDA on Tumour necrosis factor

CDC on Tumour necrosis factor

Books

Books on Tumour necrosis factor

News

Tumour necrosis factor in the news

Be alerted to news on Tumour necrosis factor

News trends on Tumour necrosis factor

Commentary

Blogs on Tumour necrosis factor

Definitions

Definitions of Tumour necrosis factor

Patient Resources / Community

Patient resources on Tumour necrosis factor

Discussion groups on Tumour necrosis factor

Patient Handouts on Tumour necrosis factor

Directions to Hospitals Treating Tumour necrosis factor

Risk calculators and risk factors for Tumour necrosis factor

Healthcare Provider Resources

Symptoms of Tumour necrosis factor

Causes & Risk Factors for Tumour necrosis factor

Diagnostic studies for Tumour necrosis factor

Treatment of Tumour necrosis factor

Continuing Medical Education (CME)

CME Programs on Tumour necrosis factor

International

Tumour necrosis factor en Espanol

Tumour necrosis factor en Francais

Business

Tumour necrosis factor in the Marketplace

Patents on Tumour necrosis factor

Experimental / Informatics

List of terms related to Tumour necrosis factor

Cardiology Network

Discuss Tumour necrosis factor further in the WikiDoc Cardiology Network
Adult Congenital
Biomarkers
Cardiac Rehabilitation
Congestive Heart Failure
CT Angiography
Echocardiography
Electrophysiology
Cardiology General
Genetics
Health Economics
Hypertension
Interventional Cardiology
MRI
Nuclear Cardiology
Peripheral Arterial Disease
Prevention
Public Policy
Pulmonary Embolism
Stable Angina
Valvular Heart Disease
Vascular Medicine

Template:WikiDoc Cardiology News Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Associate Editor-In-Chief: Cafer Zorkun, M.D., Ph.D. [2]


Overview

Tumor necrosis factors (or the TNF-family) refers to a group of cytokines family that can cause apoptosis.

Mechanism

TNF acts via the TNF Receptor (TNF-R) and is part of the extrinsic pathway for triggering apoptosis. TNF-R is associated with procaspases through adapter proteins (FADD, TRADD, etc.) that can cleave other inactive procaspases and trigger the caspase cascade, irreversibly committing the cell to apoptosis.

TNF interacts with tumor cells to trigger cytolysis or cell death.

TNF can interact with receptors on epithelial cells, which leads to increased vascular permeability allowing leukocytes access to the site of infection. This is a type of localized inflammatory response, although systemic release may lead to septic shock and death.

Types

  • Tumor necrosis factor-alpha (TNF-α) is the most well-known member of this class, and sometimes referred to when the term "tumor necrosis factor" is used.

References

  1. Lippincott's Illustrated Reviews: Immunology. Paperback: 384 pages. Publisher: Lippincott Williams & Wilkins; (July 1, 2007). Language: English. ISBN-10: 0781795435. ISBN-13: 978-0781795432. Page 68

External links

de:TNF/TNFR-Superfamilie


Template:WikiDoc Sources