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__NOTOC__
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{{Tumor lysis syndrome}}
{{Tumor lysis syndrome}}
{{CMG}} {{AE}} {{MJK}}
{{CMG}} {{shyam}} {{AE}} {{MJK}}
==Overview==
==Overview==
Laboratory findings consistent with the diagnosis of tumor lysis syndrome include high serum [[uric acid]], [[potassium]], [[phosphorus]], and low [[calcium]].<ref name="pmid15384972">{{cite journal| author=Cairo MS, Bishop M| title=Tumour lysis syndrome: new therapeutic strategies and classification. | journal=Br J Haematol | year= 2004 | volume= 127 | issue= 1 | pages= 3-11 | pmid=15384972 | doi=10.1111/j.1365-2141.2004.05094.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15384972  }} </ref>
Laboratory findings consistent with the diagnosis of tumor lysis syndrome include high serum [[uric acid]], [[potassium]], [[phosphorus]], and [[lactate dehydrogenase]]. Another laboratory abnormality is low [[calcium]].<ref name="pmid15384972">{{cite journal| author=Cairo MS, Bishop M| title=Tumour lysis syndrome: new therapeutic strategies and classification. | journal=Br J Haematol | year= 2004 | volume= 127 | issue= 1 | pages= 3-11 | pmid=15384972 | doi=10.1111/j.1365-2141.2004.05094.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15384972  }} </ref>
 
==Laboratory Findings==
==Laboratory Findings==
Laboratory findings consistent with the diagnosis of tumor lysis syndrome include:<ref name="pmid15384972">{{cite journal| author=Cairo MS, Bishop M| title=Tumour lysis syndrome: new therapeutic strategies and classification. | journal=Br J Haematol | year= 2004 | volume= 127 | issue= 1 | pages= 3-11 | pmid=15384972 | doi=10.1111/j.1365-2141.2004.05094.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15384972  }} </ref>
Laboratory findings consistent with the diagnosis of tumor lysis syndrome include:<ref name="pmid15384972">{{cite journal| author=Cairo MS, Bishop M| title=Tumour lysis syndrome: new therapeutic strategies and classification. | journal=Br J Haematol | year= 2004 | volume= 127 | issue= 1 | pages= 3-11 | pmid=15384972 | doi=10.1111/j.1365-2141.2004.05094.x | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=15384972 }} </ref><ref name="pmid18509186">{{cite journal| author=Coiffier B, Altman A, Pui CH, Younes A, Cairo MS| title=Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review. | journal=J Clin Oncol | year= 2008 | volume= 26 | issue= 16 | pages= 2767-78 | pmid=18509186 | doi=10.1200/JCO.2007.15.0177 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=18509186 }} </ref>
*Blood:
*Blood:
:*[[Hyperuricemia]] ≥ 476 μmol/l
:*[[Hyperuricemia]] ≥ 476 μmol/l
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:*[[Hyperkalemia]] ≥ 6·0 mmol/l  
:*[[Hyperkalemia]] ≥ 6·0 mmol/l  
:*[[Hypocalcemia]]  ≤ 1·75 mmol/l
:*[[Hypocalcemia]]  ≤ 1·75 mmol/l
*Urinalysis:
:*[[Creatinine]] ≥1.5 x ULN
:*[[Lactate dehydrogenase]] > ULN
:*Metabolic acidosis
*[[Urinalysis]]:
:*Low urine output
:*Low urine output
:*Uric acid crystals or amorphous urates
:*Uric acid crystals or amorphous urates
:*High uric acid-creatinine ratio > 1.0  
:*High uric acid-creatinine ratio > 1.0
 
====Cairo-Bishop Definition====
 
* '''Laboratory tumor lysis syndrome''': abnormalitiy in two or more of the following and occurs within 3 days before or 7 days after chemotherapy.
** uric acid > 8 mg/dL or 25% increase
** potassium > 6 meq/L or 25% increase
** phosphate > 4.5 mg/dL or 25% increase
** calcium < 7 mg/dL or 25% decrease
* '''Clinical tumor lysis syndrome''': laboratory tumor lysis syndrome plus one or more of the following:
** increase serum creatinine (1.5 times upper limit of normal)
** cardiac arrhythmia or sudden death
** seizure
 
A grading scale (0-5) is used depending on the presence of lab TLS, serum creatinine, arrhythmias, or seizures.


==References==
==References==
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[[Category:Blood]]
[[Category:Blood]]
[[Category:Hematology]]
[[Category:Hematology]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]

Latest revision as of 03:19, 21 January 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Shyam Patel [2] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [3]

Overview

Laboratory findings consistent with the diagnosis of tumor lysis syndrome include high serum uric acid, potassium, phosphorus, and lactate dehydrogenase. Another laboratory abnormality is low calcium.[1]

Laboratory Findings

Laboratory findings consistent with the diagnosis of tumor lysis syndrome include:[1][2]

  • Blood:
  • Low urine output
  • Uric acid crystals or amorphous urates
  • High uric acid-creatinine ratio > 1.0

References

  1. 1.0 1.1 Cairo MS, Bishop M (2004). "Tumour lysis syndrome: new therapeutic strategies and classification". Br J Haematol. 127 (1): 3–11. doi:10.1111/j.1365-2141.2004.05094.x. PMID 15384972.
  2. Coiffier B, Altman A, Pui CH, Younes A, Cairo MS (2008). "Guidelines for the management of pediatric and adult tumor lysis syndrome: an evidence-based review". J Clin Oncol. 26 (16): 2767–78. doi:10.1200/JCO.2007.15.0177. PMID 18509186.

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