Trifluperidol

Trifluperidol

File:Trifluperidol.svg
Clinical data
Routes of administration	Oral
ATC code	N05AD02 (WHO)
Identifiers
IUPAC name 1-(4-fluorophenyl)-4-[4-hydroxy-4-[3-(trifluoromethyl)phenyl]-1-piperidyl]butan-1-one
CAS Number	749-13-3
PubChem CID	5567
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C22H23F4NO2
Molar mass	409.417 g/mol

Trifluperidol is a drug which is a butyrophenone derivative. It has general properties similar to those of haloperidol, but is considerably more potent by weight, and causes relatively more severe side effects, especially tardive dyskinesia and other extrapyramidal effects. It is used in the treatment of psychoses including mania and schizophrenia.

Trifluperidol was discovered at Janssen Pharmaceutica in 1959.

References

• Gallant DM, Bishop MP, Timmons E, Steele CA, A controlled evaluation of Trifluperidol: a new potent psychopharmacologic agent, Curr Ther Res Clin Exp. 1963 Sep;27:463-71.
• Gallant DM, Bishop MP, Timmons E, Steele CA, Trifluperidol: a butyrophenone derivative, Am J Psychiatry. 1963 Nov;120:485-7.

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