Thrombocytopenia history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Farbod Zahedi Tajrishi, M.D. [2]

Overview

Since a broad spectrum of conditions can result in thrombocytopenia, an accurate history could be of great benefit in identifying the cause. The history should be thorough and include the patient's present symptoms, past medical history, family and social history as well as any history of transfusion, drug/chemical/radiation exposure or recent travel to areas that are endemic to certain infections.

Symptoms of thrombocytopenia are mainly specific to the underlying cause of the condition. Many patients may even be asymptomatic. However, common findings among symptomatic patients include the ones related to bleeding (eg, blood in stool, easy bruising, nosebleeds, abnormal menstruation, etc.) and weakness or fatigue.

History

A thorough history is essential to an effective evaluation of thrombocytopenia. While some of the conditions leading to thrombocytopenia can be immediately diagnosed, others may require specific or repeated questioning. In addition to a well-investigated present illness, a precise past medical history can help a great deal to identify the cause of thrombocytopenia. The history should include questions about:[1][2][3]

Symptoms

Thrombocytopenia usually has no symptoms and is picked up on a routine full blood count (or complete blood count). Symptomatic patients may experience:

  • malaise, fatigue and general weakness

Other symptoms associated with the specific underlying cause of thrombocytopenia may also be present.

References

  1. Greenberg EM, Kaled ES (2013). "Thrombocytopenia". Crit Care Nurs Clin North Am. 25 (4): 427–34, v. doi:10.1016/j.ccell.2013.08.003. PMID 24267279.
  2. Patel U, Gandhi G, Friedman S, Niranjan S (2004). "Thrombocytopenia in malaria". J Natl Med Assoc. 96 (9): 1212–4. PMC 2568454. PMID 15481750.
  3. West KA, Anderson DR, McAlister VC, Hewlett TJ, Belitsky P, Smith JW; et al. (1999). "Alloimmune thrombocytopenia after organ transplantation". N Engl J Med. 341 (20): 1504–7. doi:10.1056/NEJM199911113412004. PMID 10559451.

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