Tabes Dorsalis differential diagnosis: Difference between revisions
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! colspan="4" |History and Symptoms | ! colspan="4" |History and Symptoms | ||
! colspan="4" |Physical Examination | ! colspan="4" |Physical Examination | ||
!Laboratory findings | |||
! rowspan="2" |Other Findings | ! rowspan="2" |Other Findings | ||
|- style="background: #4479BA; color: #FFFFFF; text-align: center;" | |- style="background: #4479BA; color: #FFFFFF; text-align: center;" | ||
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!Broad base and sensory ataxic gait | !Broad base and sensory ataxic gait | ||
!Positive Romberg's test | !Positive Romberg's test | ||
!Key lab findings | |||
|- | |- | ||
|Tabes dorsalis | |Tabes dorsalis | ||
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|<nowiki>++</nowiki> | |<nowiki>++</nowiki> | ||
|<nowiki>++</nowiki> | |<nowiki>++</nowiki> | ||
| | |Positive [[VDRL]] and [[RPR|rapid plasma reagent]] and [[FTA-ABS|FTA-ABS) tests]] | ||
|<nowiki>-</nowiki> | |||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |B12 deficiency | | style="background: #DCDCDC; padding: 5px; text-align: center;" |B12 deficiency | ||
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| style="background: #F5F5F5; padding: 5px;" | + | | style="background: #F5F5F5; padding: 5px;" | + | ||
| style="background: #F5F5F5; padding: 5px;" | +/- | | style="background: #F5F5F5; padding: 5px;" | +/- | ||
| style="background: #F5F5F5; padding: 5px;" | | |[[Megaloblastic anemia]], | ||
Low plasma | |||
[[methylmalonic acid]] level | |||
| style="background: #F5F5F5; padding: 5px;" |Gastrointestinal symptoms, sore tongue | |||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Extrinsic spinal cord compression | | style="background: #DCDCDC; padding: 5px; text-align: center;" |Extrinsic spinal cord compression | ||
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| style="background: #F5F5F5; padding: 5px;" | +/- | | style="background: #F5F5F5; padding: 5px;" | +/- | ||
| style="background: #F5F5F5; padding: 5px;" | - | | style="background: #F5F5F5; padding: 5px;" | - | ||
| - | |||
| style="background: #F5F5F5; padding: 5px;" | | | style="background: #F5F5F5; padding: 5px;" | | ||
May be | May be | ||
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| style="background: #F5F5F5; padding: 5px;" | - | | style="background: #F5F5F5; padding: 5px;" | - | ||
| style="background: #F5F5F5; padding: 5px;" | - | | style="background: #F5F5F5; padding: 5px;" | - | ||
| style="background: #F5F5F5; padding: 5px;" |Muscle weakness | |[[Hemolytic anemia]] | ||
| style="background: #F5F5F5; padding: 5px;" |Muscle weakness, | |||
retinopathy | |||
|- | |- | ||
| style="background: #DCDCDC; padding: 5px; text-align: center;" |Multiple sclerosis | | style="background: #DCDCDC; padding: 5px; text-align: center;" |Multiple sclerosis | ||
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| style="background: #F5F5F5; padding: 5px;" | - | | style="background: #F5F5F5; padding: 5px;" | - | ||
| style="background: #F5F5F5; padding: 5px;" | +/- | | style="background: #F5F5F5; padding: 5px;" | +/- | ||
|Oligoclonal bands of IgG on electrophoresis of cerebrospinal fluid | |||
| style="background: #F5F5F5; padding: 5px;" |Vision problems' | | style="background: #F5F5F5; padding: 5px;" |Vision problems' | ||
balance problems or dizziness | balance problems or dizziness, | ||
Areas of demyelination in CNS MRI | |||
|} | |} | ||
Revision as of 17:33, 28 February 2018
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Tabes Dorsalis Microchapters |
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Treatment |
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Case Studies |
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Tabes Dorsalis differential diagnosis On the Web |
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American Roentgen Ray Society Images of Tabes Dorsalis differential diagnosis |
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Risk calculators and risk factors for Tabes Dorsalis differential diagnosis |
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Xyz Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Tabes Dorsalis differential diagnosis On the Web |
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American Roentgen Ray Society Images of Tabes Dorsalis differential diagnosis |
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Risk calculators and risk factors for Tabes Dorsalis differential diagnosis |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
Tabes dorsalis must be differentiated from other diseases that cause lightning pains, impaired sensation, ataxia and unsteady gait, such as vitamin B12 deficiency, extrinsic spinal cord compression, vitamin E deficiency and multiple sclerosis.
Differentiating tabes dorsalis from other Diseases
- Tabes dorsalis must be differentiated from other diseases that cause lightning pains, impaired sensation and proprioception, and progressive sensory ataxia and unsteady gait (locomotor ataxia) and Sexual function problems, such as vitamin B12 deficiency, extrinsic spinal cord compression, vitamin E deficiency and multiple sclerosis.[1][2][3][4]
| Diseases | History and Symptoms | Physical Examination | Laboratory findings | Other Findings | ||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Lightning pains | Impaired sensation | Progressive sensory ataxia | Unsteady gait | Argyll-Robertson pupils | Impaired vibratory and proprioception sense | Broad base and sensory ataxic gait | Positive Romberg's test | Key lab findings | ||
| Tabes dorsalis | ++ | ++ | ++ | ++ | ++ | ++ | ++ | ++ | Positive VDRL and rapid plasma reagent and FTA-ABS) tests | - |
| B12 deficiency | +/- | + | + | +/- | +/- | ++ | + | +/- | Megaloblastic anemia,
Low plasma methylmalonic acid level |
Gastrointestinal symptoms, sore tongue |
| Extrinsic spinal cord compression | +/- | +/- | +/- | +/- | - | +/- | +/- | - | - |
May be acute, subacute or chronic |
| Vitamin E deficiency | +/- | + | + | +/- | - | +/- | - | - | Hemolytic anemia | Muscle weakness,
retinopathy |
| Multiple sclerosis | +/- | +/- | +/- | +/- | very rare | +/- | - | +/- | Oligoclonal bands of IgG on electrophoresis of cerebrospinal fluid | Vision problems'
balance problems or dizziness, Areas of demyelination in CNS MRI |
References
- ↑ Clarke MW, Burnett JR, Croft KD (2008). "Vitamin E in human health and disease". Crit Rev Clin Lab Sci. 45 (5): 417–50. doi:10.1080/10408360802118625. PMID 18712629.
- ↑ Ribas ES, Schiff D (2012). "Spinal cord compression". Curr Treat Options Neurol. 14 (4): 391–401. doi:10.1007/s11940-012-0176-7. PMID 22547256.
- ↑ Oh R, Brown DL (2003). "Vitamin B12 deficiency". Am Fam Physician. 67 (5): 979–86. PMID 12643357.
- ↑ Goldenberg MM (2012). "Multiple sclerosis review". P T. 37 (3): 175–84. PMC 3351877. PMID 22605909.