Tabes Dorsalis differential diagnosis: Difference between revisions

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__NOTOC__
__NOTOC__
{{Tabes dorsalis}}
[[Image:Home_logo1.png|right|250px|link=https://www.wikidoc.org/index.php/Tabes_Dorsalis]]
 
__NOTOC__
{{xyz}}
{{CMG}}; {{AE}}{{MMJ}}
{{CMG}}; {{AE}}{{MMJ}}


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|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
! rowspan="2" |Diseases
! rowspan="2" |Diseases
! colspan="4" |History and Symptoms
! colspan="4" |History and symptoms
! colspan="4" |Physical Examination
! colspan="4" |Physical examination
! rowspan="2" |Laboratory findings
! rowspan="2" |Laboratory findings
! rowspan="2" |Other Findings
! rowspan="2" |Other findings
|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
|- style="background: #4479BA; color: #FFFFFF; text-align: center;"
!Lightning pains
!Lightning pains
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| style="background: #F5F5F5; padding: 5px;" |<nowiki>-</nowiki>
| style="background: #F5F5F5; padding: 5px;" |<nowiki>-</nowiki>
|-
|-
! style="background: #DCDCDC; padding: 5px; text-align: center;" |B12 deficiency
! style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Vitamin B12 deficiency|B12 deficiency]]
| style="background: #F5F5F5; padding: 5px;" | +/-
| style="background: #F5F5F5; padding: 5px;" | +/-
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | +
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| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* [[Megaloblastic anemia]],
* [[Megaloblastic anemia]],
* Low plasma
* Low plasma [[methylmalonic acid]] level
* [[Methylmalonic acid]] level
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* [[Gastrointestinal]] symptoms
* [[Gastrointestinal]] symptoms
* Sore tongue
* Glossitis
|-
|-
! style="background: #DCDCDC; padding: 5px; text-align: center;" |Extrinsic spinal cord compression
! style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Spinal cord compression]]
| style="background: #F5F5F5; padding: 5px;" | +/-
| style="background: #F5F5F5; padding: 5px;" | +/-
| style="background: #F5F5F5; padding: 5px;" | +/-
| style="background: #F5F5F5; padding: 5px;" | +/-
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* May be [[acute]], [[subacute]] or [[chronic]]
* May be [[acute]], [[subacute]] or [[chronic]]
|-
|-
! style="background: #DCDCDC; padding: 5px; text-align: center;" |Vitamin E deficiency
! style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Vitamin E deficiency]]
| style="background: #F5F5F5; padding: 5px;" | +/-
| style="background: #F5F5F5; padding: 5px;" | +/-
| style="background: #F5F5F5; padding: 5px;" | +
| style="background: #F5F5F5; padding: 5px;" | +
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* [[Hemolytic anemia]]
* [[Hemolytic anemia]]
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* [[Muscle weakness]],
* [[Muscle weakness|Muscle]]
* [[Muscle weakness|Weakness]]
* [[Retinopathy]]
* [[Retinopathy]]
|-
|-
! style="background: #DCDCDC; padding: 5px; text-align: center;" |Multiple sclerosis
! style="background: #DCDCDC; padding: 5px; text-align: center;" |[[Multiple sclerosis]]
| style="background: #F5F5F5; padding: 5px;" | +/-
| style="background: #F5F5F5; padding: 5px;" | +/-
| style="background: #F5F5F5; padding: 5px;" | +/-
| style="background: #F5F5F5; padding: 5px;" | +/-
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* [[Oligoclonal band|Oligoclonal bands of IgG]] on [[electrophoresis]] of [[cerebrospinal fluid]]
* [[Oligoclonal band|Oligoclonal bands of IgG]] on [[electrophoresis]] of [[cerebrospinal fluid]]
| style="background: #F5F5F5; padding: 5px;" |
| style="background: #F5F5F5; padding: 5px;" |
* [[Vision problems]]'
* [[Vision problems]]
* [[Balance disorder|balance problems]] or [[dizziness]],
* [[Balance disorder|Balance problems]]
* [[Dizziness]]
* Areas of [[demyelination]] in [[CNS]] [[MRI]]
* Areas of [[demyelination]] in [[CNS]] [[MRI]]


Latest revision as of 17:02, 13 March 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Overview

Tabes dorsalis must be differentiated from other diseases that cause lightning pains, impaired sensation, ataxia and unsteady gait, such as vitamin B12 deficiency, extrinsic spinal cord compression, vitamin E deficiency and multiple sclerosis.

Differentiating tabes dorsalis from other Diseases

Diseases History and symptoms Physical examination Laboratory findings Other findings
Lightning pains Impaired sensation Progressive sensory ataxia Unsteady gait Argyll-Robertson pupils Impaired vibratory and proprioception sense Broad base and sensory ataxic gait Positive Romberg's test
Tabes dorsalis ++ ++ ++ ++ ++ ++ ++ ++ -
B12 deficiency +/- + + +/- +/- ++ + +/-
Spinal cord compression +/- +/- +/- +/- - +/- +/- - -
Vitamin E deficiency +/- + + +/- - +/- - -
Multiple sclerosis +/- +/- +/- +/- Very rare +/- - +/-

References

  1. ↑ Clarke MW, Burnett JR, Croft KD (2008). "Vitamin E in human health and disease". Crit Rev Clin Lab Sci. 45 (5): 417–50. doi:10.1080/10408360802118625. PMID 18712629.
  2. ↑ Ribas ES, Schiff D (2012). "Spinal cord compression". Curr Treat Options Neurol. 14 (4): 391–401. doi:10.1007/s11940-012-0176-7. PMID 22547256.
  3. ↑ Oh R, Brown DL (2003). "Vitamin B12 deficiency". Am Fam Physician. 67 (5): 979–86. PMID 12643357.
  4. ↑ Goldenberg MM (2012). "Multiple sclerosis review". P T. 37 (3): 175–84. PMC 3351877. PMID 22605909.
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