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{{ | '''Tumor necrosis factor, alpha-induced protein 3''' is a [[protein]] that in humans is encoded by the ''TNFAIP3'' [[gene]].<ref name="pmid2118515">{{cite journal |author1=Opipari AW Jr |author2=Boguski MS |author3=Dixit VM | title = The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein | journal = J Biol Chem | volume = 265 | issue = 25 | pages = 14705–8 |date=October 1990 | pmid = 2118515 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TNFAIP3 tumor necrosis factor, alpha-induced protein 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7128| accessdate = }}</ref> | ||
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| summary_text = This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses.<ref name="entrez" | | summary_text = This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a [[zinc finger protein]], and has been shown to inhibit [[NF-kappa B]] activation as well as TNF-mediated [[apoptosis]]. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses.<ref name="entrez"/> | ||
}} | }} | ||
==Interactions== | |||
TNFAIP3 has been shown to [[Protein-protein interaction|interact]] with [[TNIP1]],<ref name=pmid10385526>{{cite journal |last=Heyninck |first=K |authorlink= |author2=De Valck D |author3=Vanden Berghe W |author4=Van Criekinge W |author5=Contreras R |author6=Fiers W |author7=Haegeman G |author8=Beyaert R |date=June 1999 |title=The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN |journal=J. Cell Biol. |volume=145 |issue=7 |pages=1471–82 |publisher= |location = UNITED STATES| issn = 0021-9525| pmid = 10385526 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1083/jcb.145.7.1471 |pmc=2133159 }}</ref> [[TRAF1]],<ref name=pmid8692885>{{cite journal |last=Song |first=H Y |authorlink= |author2=Rothe M |author3=Goeddel D V |date=June 1996 |title=The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=93 |issue=13 |pages=6721–5 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 8692885 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1073/pnas.93.13.6721 |pmc=39093 }}</ref><ref name=pmid9928991>{{cite journal |last=Heyninck |first=K |authorlink= |author2=Beyaert R |date=January 1999 |title=The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6 |journal=FEBS Lett. |volume=442 |issue=2–3 |pages=147–50 |publisher= |location = NETHERLANDS| issn = 0014-5793| pmid = 9928991 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0014-5793(98)01645-7 }}</ref> [[TRAF2]],<ref name=pmid8692885/> [[IKBKG]],<ref name=pmid10755617>{{cite journal |last=Zhang |first=S Q |authorlink= |author2=Kovalenko A |author3=Cantarella G |author4=Wallach D |date=March 2000 |title=Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation |journal=Immunity |volume=12 |issue=3 |pages=301–11 |publisher= |location = UNITED STATES| issn = 1074-7613| pmid = 10755617 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S1074-7613(00)80183-1 }}</ref> [[TAX1BP1]],<ref name=pmid10435631>{{cite journal |last=De Valck |first=D |authorlink= |author2=Jin D Y |author3=Heyninck K |author4=Van de Craen M |author5=Contreras R |author6=Fiers W |author7=Jeang K T |author8=Beyaert R |date=July 1999 |title=The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases |journal=Oncogene |volume=18 |issue=29 |pages=4182–90 |publisher= |location = ENGLAND| issn = 0950-9232| pmid = 10435631 |doi = 10.1038/sj.onc.1202787 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[YWHAB]],<ref name=pmid8702721>{{cite journal |last=Vincenz |first=C |authorlink= |author2=Dixit V M |date=August 1996 |title=14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules |journal=J. Biol. Chem. |volume=271 |issue=33 |pages=20029–34 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 8702721 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.271.33.20029 }}</ref> [[YWHAZ]],<ref name=pmid8702721/><ref name=pmid9299557>{{cite journal |last=De Valck |first=D |authorlink= |author2=Heyninck K |author3=Van Criekinge W |author4=Vandenabeele P |author5=Fiers W |author6=Beyaert R |date=September 1997 |title=A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins |journal=Biochem. Biophys. Res. Commun. |volume=238 |issue=2 |pages=590–4 |publisher= |location = UNITED STATES| issn = 0006-291X| pmid = 9299557 |doi = 10.1006/bbrc.1997.7343 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[TRAF6]]<ref name=pmid9928991/><ref name=pmid11463333>{{cite journal |last=Evans |first=P C |authorlink= |author2=Taylor E R |author3=Coadwell J |author4=Heyninck K |author5=Beyaert R |author6=Kilshaw P J |date=August 2001 |title=Isolation and characterization of two novel A20-like proteins |journal=Biochem. J. |volume=357 |issue=Pt 3 |pages=617–23 |publisher= |location = England| issn = 0264-6021| pmid = 11463333 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1042/0264-6021:3570617 |pmc=1221992 }}</ref> and [[YWHAH]].<ref name=pmid8702721/><ref name=pmid9299557/> | |||
==Association with rheumatoid arthritis== | |||
The TNFAIP3 locus is implicated as a positively associated factor in [[rheumatoid arthritis]] (RA). The rs5029937 (T) and the rs6920220 (A) [[single-nucleotide polymorphism|SNPs]] increase risk of RA by 20 to 40% respectively.<ref name="pmid20453842">{{cite journal |vauthors=Stahl EA, Raychaudhuri S, Remmers EF, etal | title = Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci | journal = Nat. Genet. | volume = 42 | issue = 6 | pages = 508–14 |date=June 2010 | pmid = 20453842 | doi = 10.1038/ng.582 | url = | issn = }}</ref> A third SNP, rs10499194 (T) is found less often in rheumatoid arthritis but this negative association may not be statistically meaningful. | |||
==References== | ==References== | ||
{{ | {{Reflist}} | ||
==Further reading== | ==Further reading== | ||
{{ | {{Refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | *{{cite journal |vauthors=Dixit VM, Green S, Sarma V, etal |title=Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin |journal=J. Biol. Chem. |volume=265 |issue= 5 |pages= 2973–8 |year= 1990 |pmid= 2406243 |doi= }} | ||
*{{cite journal | *{{cite journal |vauthors=Cooper JT, Stroka DM, Brostjan C, etal |title=A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism |journal=J. Biol. Chem. |volume=271 |issue= 30 |pages= 18068–73 |year= 1996 |pmid= 8663499 |doi=10.1074/jbc.271.30.18068 }} | ||
*{{cite journal | *{{cite journal |vauthors=Meng Z, Zhao T, Zhou K, etal |title=A20 Ameliorates Intracerebral Hemorrhage-Induced Inflammatory Injury by Regulating TRAF6 Polyubiquitination |journal=J. Immunol. |volume=198 |issue= 2 |pages= 820–31 |year= 2017 |pmid= 27986908 |doi=10.4049/jimmunol.1600334 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Song HY, Rothe M, Goeddel DV |title=The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 13 |pages= 6721–5 |year= 1996 |pmid= 8692885 |doi=10.1073/pnas.93.13.6721 | pmc=39093 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Vincenz C, Dixit VM |title=14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules |journal=J. Biol. Chem. |volume=271 |issue= 33 |pages= 20029–34 |year= 1996 |pmid= 8702721 |doi=10.1074/jbc.271.33.20029 }} | ||
*{{cite journal | *{{cite journal |vauthors=De Valck D, Heyninck K, Van Criekinge W, etal |title=A20, an inhibitor of cell death, self-associates by its zinc finger domain |journal=FEBS Lett. |volume=384 |issue= 1 |pages= 61–4 |year= 1996 |pmid= 8797804 |doi=10.1016/0014-5793(96)00283-9 }} | ||
*{{cite journal | *{{cite journal |vauthors=De Valck D, Heyninck K, Van Criekinge W, etal |title=A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins |journal=Biochem. Biophys. Res. Commun. |volume=238 |issue= 2 |pages= 590–4 |year= 1997 |pmid= 9299557 |doi= 10.1006/bbrc.1997.7343 }} | ||
*{{cite journal | *{{cite journal |vauthors=Eliopoulos AG, Blake SM, Floettmann JE, etal |title=Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2 |journal=J. Virol. |volume=73 |issue= 2 |pages= 1023–35 |year= 1999 |pmid= 9882303 |doi= | pmc=103922 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Heyninck K, Beyaert R |title=The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6 |journal=FEBS Lett. |volume=442 |issue= 2–3 |pages= 147–50 |year= 1999 |pmid= 9928991 |doi=10.1016/S0014-5793(98)01645-7 }} | ||
*{{cite journal | *{{cite journal |vauthors=Heyninck K, De Valck D, Vanden Berghe W, etal |title=The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN |journal=J. Cell Biol. |volume=145 |issue= 7 |pages= 1471–82 |year= 1999 |pmid= 10385526 |doi=10.1083/jcb.145.7.1471 | pmc=2133159 }} | ||
*{{cite journal | *{{cite journal |vauthors=De Valck D, Jin DY, Heyninck K, etal |title=The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases |journal=Oncogene |volume=18 |issue= 29 |pages= 4182–90 |year= 1999 |pmid= 10435631 |doi= 10.1038/sj.onc.1202787 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Zhang SQ, Kovalenko A, Cantarella G, Wallach D |title=Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation |journal=Immunity |volume=12 |issue= 3 |pages= 301–11 |year= 2000 |pmid= 10755617 |doi=10.1016/S1074-7613(00)80183-1 }} | ||
*{{cite journal | *{{cite journal |vauthors=Lee EG, Boone DL, Chai S, etal |title=Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice |journal=Science |volume=289 |issue= 5488 |pages= 2350–4 |year= 2000 |pmid= 11009421 |doi=10.1126/science.289.5488.2350 |pmc=3582399}} | ||
*{{cite journal | | *{{cite journal |vauthors=Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R |title=Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions |journal=FEBS Lett. |volume=498 |issue= 1 |pages= 93–7 |year= 2001 |pmid= 11389905 |doi=10.1016/S0014-5793(01)02504-2 }} | ||
*{{cite journal | *{{cite journal |vauthors=Van Huffel S, Delaei F, Heyninck K, etal |title=Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2 |journal=J. Biol. Chem. |volume=276 |issue= 32 |pages= 30216–23 |year= 2001 |pmid= 11390377 |doi= 10.1074/jbc.M100048200 }} | ||
*{{cite journal | *{{cite journal |vauthors=Evans PC, Taylor ER, Coadwell J, etal |title=Isolation and characterization of two novel A20-like proteins |journal=Biochem. J. |volume=357 |issue= Pt 3 |pages= 617–23 |year= 2001 |pmid= 11463333 |doi=10.1042/0264-6021:3570617 | pmc=1221992 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Baltathakis I, Alcantara O, Boldt DH |title=Expression of different NF-kappaB pathway genes in dendritic cells (DCs) or macrophages assessed by gene expression profiling |journal=J. Cell. Biochem. |volume=83 |issue= 2 |pages= 281–90 |year= 2001 |pmid= 11573245 |doi=10.1002/jcb.1231 }} | ||
*{{cite journal | *{{cite journal |vauthors=Zetoune FS, Murthy AR, Shao Z, etal |title=A20 inhibits NF-kappa B activation downstream of multiple Map3 kinases and interacts with the I kappa B signalosome |journal=Cytokine |volume=15 |issue= 6 |pages= 282–98 |year= 2002 |pmid= 11594795 |doi= 10.1006/cyto.2001.0921 }} | ||
*{{cite journal | | *{{cite journal |vauthors=Wu WS, Xu ZX, Chang KS |title=The promyelocytic leukemia protein represses A20-mediated transcription |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31734–9 |year= 2002 |pmid= 12080044 |doi= 10.1074/jbc.M201648200 }} | ||
*{{cite journal | | *{{cite journal |vauthors=He KL, Ting AT |title=A20 inhibits tumor necrosis factor (TNF) alpha-induced apoptosis by disrupting recruitment of TRADD and RIP to the TNF receptor 1 complex in Jurkat T cells |journal=Mol. Cell. Biol. |volume=22 |issue= 17 |pages= 6034–45 |year= 2002 |pmid= 12167698 |doi=10.1128/MCB.22.17.6034-6045.2002 | pmc=133997 }} | ||
}} | }} | ||
{{ | {{Refend}} | ||
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Revision as of 03:34, 11 November 2017
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Tumor necrosis factor, alpha-induced protein 3 is a protein that in humans is encoded by the TNFAIP3 gene.[1][2]
This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. Knockout studies of a similar gene in mice suggested that this gene is critical for limiting inflammation by terminating TNF-induced NF-kappa B responses.[2]
Interactions
TNFAIP3 has been shown to interact with TNIP1,[3] TRAF1,[4][5] TRAF2,[4] IKBKG,[6] TAX1BP1,[7] YWHAB,[8] YWHAZ,[8][9] TRAF6[5][10] and YWHAH.[8][9]
Association with rheumatoid arthritis
The TNFAIP3 locus is implicated as a positively associated factor in rheumatoid arthritis (RA). The rs5029937 (T) and the rs6920220 (A) SNPs increase risk of RA by 20 to 40% respectively.[11] A third SNP, rs10499194 (T) is found less often in rheumatoid arthritis but this negative association may not be statistically meaningful.
References
- ↑ Opipari AW Jr; Boguski MS; Dixit VM (October 1990). "The A20 cDNA induced by tumor necrosis factor alpha encodes a novel type of zinc finger protein". J Biol Chem. 265 (25): 14705–8. PMID 2118515.
- ↑ 2.0 2.1 "Entrez Gene: TNFAIP3 tumor necrosis factor, alpha-induced protein 3".
- ↑ Heyninck, K; De Valck D; Vanden Berghe W; Van Criekinge W; Contreras R; Fiers W; Haegeman G; Beyaert R (June 1999). "The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN". J. Cell Biol. UNITED STATES. 145 (7): 1471–82. doi:10.1083/jcb.145.7.1471. ISSN 0021-9525. PMC 2133159. PMID 10385526.
- ↑ 4.0 4.1 Song, H Y; Rothe M; Goeddel D V (June 1996). "The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 93 (13): 6721–5. doi:10.1073/pnas.93.13.6721. ISSN 0027-8424. PMC 39093. PMID 8692885.
- ↑ 5.0 5.1 Heyninck, K; Beyaert R (January 1999). "The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6". FEBS Lett. NETHERLANDS. 442 (2–3): 147–50. doi:10.1016/S0014-5793(98)01645-7. ISSN 0014-5793. PMID 9928991.
- ↑ Zhang, S Q; Kovalenko A; Cantarella G; Wallach D (March 2000). "Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation". Immunity. UNITED STATES. 12 (3): 301–11. doi:10.1016/S1074-7613(00)80183-1. ISSN 1074-7613. PMID 10755617.
- ↑ De Valck, D; Jin D Y; Heyninck K; Van de Craen M; Contreras R; Fiers W; Jeang K T; Beyaert R (July 1999). "The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases". Oncogene. ENGLAND. 18 (29): 4182–90. doi:10.1038/sj.onc.1202787. ISSN 0950-9232. PMID 10435631.
- ↑ 8.0 8.1 8.2 Vincenz, C; Dixit V M (August 1996). "14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules". J. Biol. Chem. UNITED STATES. 271 (33): 20029–34. doi:10.1074/jbc.271.33.20029. ISSN 0021-9258. PMID 8702721.
- ↑ 9.0 9.1 De Valck, D; Heyninck K; Van Criekinge W; Vandenabeele P; Fiers W; Beyaert R (September 1997). "A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins". Biochem. Biophys. Res. Commun. UNITED STATES. 238 (2): 590–4. doi:10.1006/bbrc.1997.7343. ISSN 0006-291X. PMID 9299557.
- ↑ Evans, P C; Taylor E R; Coadwell J; Heyninck K; Beyaert R; Kilshaw P J (August 2001). "Isolation and characterization of two novel A20-like proteins". Biochem. J. England. 357 (Pt 3): 617–23. doi:10.1042/0264-6021:3570617. ISSN 0264-6021. PMC 1221992. PMID 11463333.
- ↑ Stahl EA, Raychaudhuri S, Remmers EF, et al. (June 2010). "Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci". Nat. Genet. 42 (6): 508–14. doi:10.1038/ng.582. PMID 20453842.
Further reading
- Dixit VM, Green S, Sarma V, et al. (1990). "Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin". J. Biol. Chem. 265 (5): 2973–8. PMID 2406243.
- Cooper JT, Stroka DM, Brostjan C, et al. (1996). "A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism". J. Biol. Chem. 271 (30): 18068–73. doi:10.1074/jbc.271.30.18068. PMID 8663499.
- Meng Z, Zhao T, Zhou K, et al. (2017). "A20 Ameliorates Intracerebral Hemorrhage-Induced Inflammatory Injury by Regulating TRAF6 Polyubiquitination". J. Immunol. 198 (2): 820–31. doi:10.4049/jimmunol.1600334. PMID 27986908.
- Song HY, Rothe M, Goeddel DV (1996). "The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation". Proc. Natl. Acad. Sci. U.S.A. 93 (13): 6721–5. doi:10.1073/pnas.93.13.6721. PMC 39093. PMID 8692885.
- Vincenz C, Dixit VM (1996). "14-3-3 proteins associate with A20 in an isoform-specific manner and function both as chaperone and adapter molecules". J. Biol. Chem. 271 (33): 20029–34. doi:10.1074/jbc.271.33.20029. PMID 8702721.
- De Valck D, Heyninck K, Van Criekinge W, et al. (1996). "A20, an inhibitor of cell death, self-associates by its zinc finger domain". FEBS Lett. 384 (1): 61–4. doi:10.1016/0014-5793(96)00283-9. PMID 8797804.
- De Valck D, Heyninck K, Van Criekinge W, et al. (1997). "A20 inhibits NF-kappaB activation independently of binding to 14-3-3 proteins". Biochem. Biophys. Res. Commun. 238 (2): 590–4. doi:10.1006/bbrc.1997.7343. PMID 9299557.
- Eliopoulos AG, Blake SM, Floettmann JE, et al. (1999). "Epstein-Barr virus-encoded latent membrane protein 1 activates the JNK pathway through its extreme C terminus via a mechanism involving TRADD and TRAF2". J. Virol. 73 (2): 1023–35. PMC 103922. PMID 9882303.
- Heyninck K, Beyaert R (1999). "The cytokine-inducible zinc finger protein A20 inhibits IL-1-induced NF-kappaB activation at the level of TRAF6". FEBS Lett. 442 (2–3): 147–50. doi:10.1016/S0014-5793(98)01645-7. PMID 9928991.
- Heyninck K, De Valck D, Vanden Berghe W, et al. (1999). "The zinc finger protein A20 inhibits TNF-induced NF-kappaB-dependent gene expression by interfering with an RIP- or TRAF2-mediated transactivation signal and directly binds to a novel NF-kappaB-inhibiting protein ABIN". J. Cell Biol. 145 (7): 1471–82. doi:10.1083/jcb.145.7.1471. PMC 2133159. PMID 10385526.
- De Valck D, Jin DY, Heyninck K, et al. (1999). "The zinc finger protein A20 interacts with a novel anti-apoptotic protein which is cleaved by specific caspases". Oncogene. 18 (29): 4182–90. doi:10.1038/sj.onc.1202787. PMID 10435631.
- Zhang SQ, Kovalenko A, Cantarella G, Wallach D (2000). "Recruitment of the IKK signalosome to the p55 TNF receptor: RIP and A20 bind to NEMO (IKKgamma) upon receptor stimulation". Immunity. 12 (3): 301–11. doi:10.1016/S1074-7613(00)80183-1. PMID 10755617.
- Lee EG, Boone DL, Chai S, et al. (2000). "Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice". Science. 289 (5488): 2350–4. doi:10.1126/science.289.5488.2350. PMC 3582399. PMID 11009421.
- Klinkenberg M, Van Huffel S, Heyninck K, Beyaert R (2001). "Functional redundancy of the zinc fingers of A20 for inhibition of NF-kappaB activation and protein-protein interactions". FEBS Lett. 498 (1): 93–7. doi:10.1016/S0014-5793(01)02504-2. PMID 11389905.
- Van Huffel S, Delaei F, Heyninck K, et al. (2001). "Identification of a novel A20-binding inhibitor of nuclear factor-kappa B activation termed ABIN-2". J. Biol. Chem. 276 (32): 30216–23. doi:10.1074/jbc.M100048200. PMID 11390377.
- Evans PC, Taylor ER, Coadwell J, et al. (2001). "Isolation and characterization of two novel A20-like proteins". Biochem. J. 357 (Pt 3): 617–23. doi:10.1042/0264-6021:3570617. PMC 1221992. PMID 11463333.
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