T-cell prolymphocytic leukemia laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
In T-cell prolymphocytic leukemia peripheral blood | In [[T cell|T-cell]] [[prolymphocytic leukemia]], the [[peripheral blood smear]] demonstrates the predominance of [[lymphocytes]] and high [[lymphocyte]] count (> 100 x 109/L). | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
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:*[[Thrombocytopenia]] | :*[[Thrombocytopenia]] | ||
:*Negative [[Human T-lymphotropic virus|human T lymphotropic virus]] ([[Human T-lymphotropic virus|HTLV]]) serology | :*Negative [[Human T-lymphotropic virus|human T lymphotropic virus]] ([[Human T-lymphotropic virus|HTLV]]) serology | ||
:*Peripheral Blood Smear demonstrated predominance of [[lymphocytes]]: | :*[[Peripheral blood smear|Peripheral Blood Smear]] demonstrated predominance of [[lymphocytes]]: | ||
:**Typical variant: | :**Typical variant: | ||
:*** Medium-sized [[lymphocytes]] | :*** Medium-sized [[lymphocytes]] | ||
:*** Condensed chromatin and a visible nucleolus | :*** Condensed [[chromatin]] and a visible [[nucleolus]] | ||
:*** Round nucleus | :*** Round [[Cell nucleus|nucleus]] | ||
:*** Slightly basophilic cytoplasm | :*** Slightly [[basophilic]] [[cytoplasm]] | ||
:*** Cytoplasmic protrusion | :*** [[Cytoplasm|Cytoplasmic]] protrusion | ||
:**Small cell variant | :**[[Small cell]] variant | ||
:*** Small tumor cells with condensed chromatin | :*** Small [[tumor]] cells with condensed [[chromatin]] | ||
:*** Small nucleolus visible by electron microscopy | :*** Small [[nucleolus]] visible by [[electron microscopy]] | ||
:**Cerebriform (Sézary cell-like) variant | :**Cerebriform ([[Sézary's disease|Sézary]] cell-like) variant | ||
:*** Irregular nuclear outline | :*** Irregular [[nuclear]] outline | ||
:*** Similar to cerebriform nucleus of Sézary cells seen in mycosis fungoides | :*** Similar to cerebriform nucleus of [[Sézary|Sézary cells]] seen in [[mycosis fungoides]] | ||
==References== | ==References== | ||
Revision as of 13:18, 4 April 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Qurrat-ul-ain Abid, M.D.[2], Maria Fernanda Villarreal, M.D. [3]
Overview
In T-cell prolymphocytic leukemia, the peripheral blood smear demonstrates the predominance of lymphocytes and high lymphocyte count (> 100 x 109/L).
Laboratory Findings
- Laboratory findings consistent with the diagnosis of T-cell prolymphocytic leukemia, include:[1]
- High lymphocyte count (> 100 x 109/L)
- Anemia
- Thrombocytopenia
- Negative human T lymphotropic virus (HTLV) serology
- Peripheral Blood Smear demonstrated predominance of lymphocytes:
- Typical variant:
- Medium-sized lymphocytes
- Condensed chromatin and a visible nucleolus
- Round nucleus
- Slightly basophilic cytoplasm
- Cytoplasmic protrusion
- Small cell variant
- Small tumor cells with condensed chromatin
- Small nucleolus visible by electron microscopy
- Cerebriform (Sézary cell-like) variant
- Irregular nuclear outline
- Similar to cerebriform nucleus of Sézary cells seen in mycosis fungoides
- Typical variant: