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At present the pathophysiology of SCAD continues to be poorly understood due to the rarity of this condition and its heterogeneous pathology. In SCAD the affected [[coronary artery]] develops a tear, causing blood to flow between the coronary arterial layers eventually forcing them apart. The pattern of dissection in SCAD is different from the pattern observed in patients with pre-existing [[atherosclerosis]]. In SCAD the plane of dissection lies within the outer third of the [[tunica media]] or between the [[media]] and [[adventitia]]. Dissections can be present in either one artery or several arteries concomitantly.<ref name="pmid12403896">{{cite journal |author=Choi JW, Davidson CJ |title=Spontaneous multivessel coronary artery dissection in a long-distance runner successfully treated with oral antiplatelet therapy |journal=[[The Journal of Invasive Cardiology]] |volume=14 |issue=11 |pages=675–8 |year=2002 |month=November |pmid=12403896 |doi= |url=}}</ref> The dissecting plane between [[intima]] and [[media]] creates a false lumen and the resulting [[hematoma]] compresses the vessel lumen causing [[myocardial ischemia]] or [[myocardial infarction]] (MI).
At present the pathophysiology of SCAD continues to be poorly understood due to the rarity of this condition and its heterogeneous pathology. In SCAD the affected [[coronary artery]] develops a tear, causing blood to flow between the coronary arterial layers eventually forcing them apart. The pattern of dissection in SCAD is different from the pattern observed in patients with pre-existing [[atherosclerosis]]. In SCAD the plane of dissection lies within the outer third of the [[tunica media]] or between the [[media]] and [[adventitia]]. Dissections can be present in either one artery or several arteries concomitantly.<ref name="pmid12403896">{{cite journal |author=Choi JW, Davidson CJ |title=Spontaneous multivessel coronary artery dissection in a long-distance runner successfully treated with oral antiplatelet therapy |journal=[[The Journal of Invasive Cardiology]] |volume=14 |issue=11 |pages=675–8 |year=2002 |month=November |pmid=12403896 |doi= |url=}}</ref> The dissecting plane between [[intima]] and [[media]] creates a false lumen and the resulting [[hematoma]] compresses the vessel lumen causing [[myocardial ischemia]] or [[myocardial infarction]] (MI).
Although intimal tear or bleeding of vasa vasorum with intramedial hemorrhage seems to be most probable reason, the exact underlying mechanism of non-atherosclerotic spontaneous coronary artery dissection (NA-SCAD) is still unknown [1]. Consequently intramural hematoma creates a false lumen [2]. Progressive expansion of the false lumen may cause subsequent myocardial ischemia and infarction.


==References==
==References==

Revision as of 17:58, 22 November 2017

Spontaneous Coronary Artery Dissection Microchapters

Home

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Spontaneous coronary artery dissection from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Approach

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

Angiography

CT

MRI

Echocardiography

Other Imaging Findings

Other Diagnostic Studies

Treatment

Treatment Approach

Medical Therapy

Percutaneous Coronary Intervention

Surgery

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

Case Studies

Type 1

Type 2A

Type 2B

Type 3

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Nate Michalak, B.A.

Synonyms and keywords: SCAD

Overview

Pathophysiology

At present the pathophysiology of SCAD continues to be poorly understood due to the rarity of this condition and its heterogeneous pathology. In SCAD the affected coronary artery develops a tear, causing blood to flow between the coronary arterial layers eventually forcing them apart. The pattern of dissection in SCAD is different from the pattern observed in patients with pre-existing atherosclerosis. In SCAD the plane of dissection lies within the outer third of the tunica media or between the media and adventitia. Dissections can be present in either one artery or several arteries concomitantly.[1] The dissecting plane between intima and media creates a false lumen and the resulting hematoma compresses the vessel lumen causing myocardial ischemia or myocardial infarction (MI).

Although intimal tear or bleeding of vasa vasorum with intramedial hemorrhage seems to be most probable reason, the exact underlying mechanism of non-atherosclerotic spontaneous coronary artery dissection (NA-SCAD) is still unknown [1]. Consequently intramural hematoma creates a false lumen [2]. Progressive expansion of the false lumen may cause subsequent myocardial ischemia and infarction.

References

  1. Choi JW, Davidson CJ (2002). "Spontaneous multivessel coronary artery dissection in a long-distance runner successfully treated with oral antiplatelet therapy". The Journal of Invasive Cardiology. 14 (11): 675–8. PMID 12403896. Unknown parameter |month= ignored (help)