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==Staging==
==Staging==
The American Joint Committee on Cancer (AJCC) includes [[tumor marker|serum tumor marker levels]] in the stages for germ cell tumors, including seminoma. '''S''' describes the levels of serum tumour markers in the blood after [[orchiectomy]]. The serum tumor markers measured are [[AFP|alpha-fetoprotein (AFP)]], [[HCG|human chorionic gonadotropin (HCG)]], and [[LDH|lactate dehydrogenase (LDH)]].<ref name=stagingofgermcelltumors1>Staging testicular cancer. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/staging/?region=on. Accessed on February 26, 2016</ref>
{| style="border: 0px; font-size: 90%; margin: 3px; width:1000px"
|valign=top|
|+
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|S}}
! style="background: #4479BA; width: 800px;" | {{fontcolor|#FFF|Serum tumor marker levels}}
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" align=center |SX
| style="padding: 5px 5px; background: #F5F5F5;" |Tumor marker levels are not available or have not been measured.
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" align=center |S0
| style="padding: 5px 5px; background: #F5F5F5;" |Tumor marker levels are normal.
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" align=center |S1
| style="padding: 5px 5px; background: #F5F5F5;" |All tumor marker levels are above normal.
*AFP is less than 1,000 ng/mL.
*HCG is less than 5,000 mIU/mL.
*LDH is less than 1.5 times the upper limit of the normal range.
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" align=center|
Stage IV
| style="padding: 5px 5px; background: #F5F5F5;" |
Disseminated spread to extranodal sites or spread to the lymph nodes above the diaphragm (supradiaphragmatic nodal involvement)
|}


==References==
==References==

Revision as of 14:54, 26 February 2016

Seminoma Microchapters

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Risk calculators and risk factors for Seminoma staging

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Staging

The American Joint Committee on Cancer (AJCC) includes serum tumor marker levels in the stages for germ cell tumors, including seminoma. S describes the levels of serum tumour markers in the blood after orchiectomy. The serum tumor markers measured are alpha-fetoprotein (AFP), human chorionic gonadotropin (HCG), and lactate dehydrogenase (LDH).[1]

S Serum tumor marker levels
SX Tumor marker levels are not available or have not been measured.
S0 Tumor marker levels are normal.
S1 All tumor marker levels are above normal.
  • AFP is less than 1,000 ng/mL.
  • HCG is less than 5,000 mIU/mL.
  • LDH is less than 1.5 times the upper limit of the normal range.

Stage IV

Disseminated spread to extranodal sites or spread to the lymph nodes above the diaphragm (supradiaphragmatic nodal involvement)

References

  1. Staging testicular cancer. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/staging/?region=on. Accessed on February 26, 2016

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