Seminoma causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sogand Goudarzi, MD [2]
Overview
Common causes of seminoma include: cryptorchidism, undeescending testis, abdominal testis, trauma, mumps, maternal estrogen exposure.Seminoma is caused by a mutation in the KIT gene. 12p11.2-p12.1 chromosomal amplifications and deletions observed in majority of cases of seminoma.
Causes
Common Causes
Common causes of seminoma may include:[1][2]
Genetic Causes
- Seminoma is caused by a mutation in the KIT gene.[3]
- 12p11.2-p12.1 chromosomal amplifications and deletions observed in majority of cases.[4]
References
- ↑ Ferguson L, Agoulnik AI (2013). "Testicular cancer and cryptorchidism". Front Endocrinol (Lausanne). 4: 32. doi:10.3389/fendo.2013.00032. PMID 23519268.
- ↑ Merzenich H, Ahrens W, Stang A, Baumgardt-Elms C, Jahn I, Stegmaier C, Jöckel KH (December 2000). "Sorting the hype from the facts in testicular cancer: is testicular cancer related to trauma?". J. Urol. 164 (6): 2143–4. PMID 11061944.
- ↑ Coffey J, Linger R, Pugh J, Dudakia D, Sokal M, Easton DF, Timothy Bishop D, Stratton M, Huddart R, Rapley EA (January 2008). "Somatic KIT mutations occur predominantly in seminoma germ cell tumors and are not predictive of bilateral disease: report of 220 tumors and review of literature". Genes Chromosomes Cancer. 47 (1): 34–42. doi:10.1002/gcc.20503. PMID 17943970.
- ↑ Woldu SL, Amatruda JF, Bagrodia A (January 2017). "Testicular germ cell tumor genomics". Curr Opin Urol. 27 (1): 41–47. doi:10.1097/MOU.0000000000000347. PMC 6368344. PMID 27584029.