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Revision as of 16:37, 27 November 2017

Seminoma Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

On gross pathology, seminoma is characterized by pale gray to yellow nodules that are uniform or slightly lobulated and often bulge from the cut surface.[1] On microscopic pathology, seminoma is characterized by the cells with fried egg appearance with clear cytoplasm and central nucleus with prominent nucleolus, with interspersed lymphocytes and syncytiotrophoblasts.[2] Approximately 24% of Stage I seminomas have lymphovascular invasion for stage I (Tx, N0, M0). Intertubular seminoma may not form a discrete mass and mimic a benign testis.[2] Seminoma is demonstrated by positivity to tumor markers, such as OCT4, CD117, D2-40, and CD117.[3]

Gross Pathology

On gross pathology, seminoma is characterized by pale gray to yellow nodules that are uniform or slightly lobulated and often bulge from the cut surface.[1]

Gallery

Microscopic Pathology

  • On microscopic pathology, seminoma is characterized by:[2]
  • Cells with fried egg appearance - key feature
  • Clear cytoplasm
  • Central nucleus, with prominent nucleolus. Nucleus may have "corners", i.e. it is not round.
  • Large, irregular, vesicular nuclei
  • Eosinophilic vacuolated cytoplasm (contains hCG)
  • Florid granulomatous reaction
  • Approximately 24% of Stage I seminomas have lymphovascular invasion for stage I (Tx, N0, M0).[2]
  • Intertubular seminoma may not form a discrete mass and mimic a benign testis.[2]

Gallery

Immunohistochemistry

Seminoma is demonstrated by positivity to tumor markers, such as:[3]

References

  1. 1.0 1.1 Pathology of testicular seminoma. Dr Marcin Czarniecki and Dr Andrew Dixon et al. Radiipaedia 2016. http://radiopaedia.org/articles/testicular-seminoma-1. Accessed on February 29, 2016
  2. 2.0 2.1 2.2 2.3 2.4 2.5 2.6 2.7 2.8 Microscopic pathology of seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016
  3. 3.0 3.1 IHC for seminoma. Libre pathology 2016. http://librepathology.org/wiki/Seminoma. Accessed on March 3, 2016

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