Seminoma medical therapy: Difference between revisions

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Revision as of 16:37, 27 November 2017

Seminoma Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

The optimal therapy for seminoma depends on the stage at diagnosis.[1]

Medical Therapy

  • In case of seminoma, the healthcare team creates an individualized treatment plan. It is generally based on the patient's needs and may include a combination of different treatments. The factors which help in deciding the treatment plan for seminoma include:[1]
  • Stage of seminoma
  • Risk of recurrence
  • Fertility
  • Preferences of the individual
  • The various treatment options depending on the stage and recurrence risk of seminoma are discussed below.[2][3][4][5][6]


 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Treatment of Seminoma
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Stage I
 
 
 
Stage II
 
 
 
 
 
Stage III
 
 
 
Recurrent
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
Surgery
❑ Active surveillance
Radiotherapy
Chemotherapy
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

Chemotherapy

  • Chemotherapy is a common treatment for all stages of seminoma. It is usually given after an orchiectomy. A combination of chemotherapy drugs is usually given.[7]
  • BEP is the main chemotherapy combination used for seminoma. It includes bleomycin, etoposide, and cisplatin.
  • Sometimes, physicians just give etoposide and cisplatin (called EP). EP is given when bleomycin affects the lungs (called pulmonary toxicity), or there is a high risk that it will cause lung damage.
  • High-dose chemotherapy and stem cell transplant may be used for recurrent testicular cancer, if the standard-dose chemotherapy doesn’t work and the cancer comes back.
  • High doses of carboplatin and etoposide are given. After high-dose chemotherapy, a stem cell transplant is done to replace the stem cells that are damaged or destroyed by high-dose chemotherapy. The stem cell transplant is an autologous peripheral blood stem cell transplant.[7]

Radiotherapy

Active Surveillance

  • Active surveillance is the preferred treatment for stage I seminoma after a radical inguinal orchiectomy.[7]
  • During active surveillance, the healthcare team watches for any signs and symptoms of recurrence. Treatment is given only if seminoma recurs.[7]
  • There are no standard active surveillance schedules for seminoma. Active surveillance may last for 5-10 years. You may have follow-up visits every 2-6 months for the first 3 years.[8]
  • Tests that are often done during a follow-up visit include:[8]

References

  1. 1.0 1.1 Treatments for testicular cancer. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/?region=on. Accessed on March 1, 2016
  2. Treatment for testicular cancer. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/?region=on. Accessed on March 1, 2016
  3. Treatments for stage I seminoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/seminoma/stage-i/?region=on. Accessed on March 1, 2016
  4. Treatments for stage II seminoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/seminoma/stage-ii/?region=on. Accessed on March 1, 2016
  5. Treatments for stage III seminoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/seminoma/stage-iii/?region=on. Accessed on March 1, 2016
  6. Treatments for recurrent seminoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/seminoma/recurrent/?region=on. Accessed on March 1, 2016
  7. 7.0 7.1 7.2 7.3 7.4 7.5 Treatments for testicular cancer. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/?region=on. Accessed on March 2, 2016
  8. 8.0 8.1 Active surveillance for testicular cancer. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/active-surveillance/?region=on. Accessed on March 2, 2016

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