Seminoma medical therapy: Difference between revisions
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==Overview== | ==Overview== | ||
==Medical Therapy== | ==Medical Therapy== | ||
In case of seminoma, the healthcare team creates an individualized treatment plan. It is generally based on the patient's needs and may include a combination of different treatments. The factors which help in deciding the treatment plan for seminoma include:<ref name= | In case of seminoma, the healthcare team creates an individualized treatment plan. It is generally based on the patient's needs and may include a combination of different treatments. The factors which help in deciding the treatment plan for seminoma include:<ref name=treatmentsoftesticularcancer>Treatments for testicular cancer. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/?region=on. Accessed on March 1, 2016</ref> | ||
*Stage of seminoma | *Stage of seminoma | ||
*Risk of recurrence | *Risk of recurrence | ||
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{{familytree |boxstyle=background: #DCDCDC;| | | | | | | C01 | | | | C02 | | | | | | C03 | | | | C04 | | | | |C01=<div style="width: 10em; padding:0.2em;">❑ [[Surgery]]<br>❑ Active surveillance<br>❑ [[Radiotherapy]]<br>❑ [[Chemotherapy]]</div>|C02=<div style="width: 10em; padding:0.2em;">❑ [[Surgery]]<br>❑ [[Radiotherapy]]<br>❑ [[Chemotherapy]]</div>|C03=<div style="width: 10m; padding:0.2em;">❑ [[Surgery]]<br>❑ [[Chemotherapy]]</div>|C04=<div style="width: 10em; padding:0.2em;">❑ [[Chemotherapy]]<br>❑ [[Hematopoietic stem cell transplantation|Stem Cell Transplantation]]<br>❑ [[Surgery]]</div>}} | {{familytree |boxstyle=background: #DCDCDC;| | | | | | | C01 | | | | C02 | | | | | | C03 | | | | C04 | | | | |C01=<div style="width: 10em; padding:0.2em;">❑ [[Surgery]]<br>❑ Active surveillance<br>❑ [[Radiotherapy]]<br>❑ [[Chemotherapy]]</div>|C02=<div style="width: 10em; padding:0.2em;">❑ [[Surgery]]<br>❑ [[Radiotherapy]]<br>❑ [[Chemotherapy]]</div>|C03=<div style="width: 10m; padding:0.2em;">❑ [[Surgery]]<br>❑ [[Chemotherapy]]</div>|C04=<div style="width: 10em; padding:0.2em;">❑ [[Chemotherapy]]<br>❑ [[Hematopoietic stem cell transplantation|Stem Cell Transplantation]]<br>❑ [[Surgery]]</div>}} | ||
{{familytree/end}} | {{familytree/end}} | ||
==Chemotherapy== | |||
*[[Chemotherapy]] is a common treatment for all stages of seminoma. It is usually given after an [[orchiectomy]]. A combination of chemotherapy drugs is usually given.<ref name=treatmentsoftesticularcancer2>Treatments for testicular cancer. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/?region=on. Accessed on March 2, 2016</ref> | |||
*'''BEP''' is the main chemotherapy combination used for seminoma. It includes [[bleomycin]], [[etoposide]], and [[cisplatin]]. | |||
*Sometimes, physicians just give [[etoposide]] and [[cisplatin]] (called EP). '''EP''' is given when [[bleomycin]] affects the lungs (called ''pulmonary toxicity''), or there is a high risk that it will cause lung damage. | |||
*High-dose chemotherapy and [[Hematopoietic stem cell transplantation|stem cell transplant]] may be used for '''recurrent''' testicular cancer, if the standard-dose chemotherapy doesn’t work and the cancer comes back. | |||
*High doses of [[carboplatin]] and [[etoposide]] are given. After high-dose chemotherapy, a stem cell transplant is done to replace the stem cells that are damaged or destroyed by high-dose chemotherapy. The stem cell transplant is an autologous peripheral blood stem cell transplant.<ref name=treatmentsoftesticularcancer2>Treatments for testicular cancer. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/?region=on. Accessed on March 2, 2016</ref> | |||
==References== | ==References== | ||
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[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
[[Category: | [[Category:Oncology]] | ||
{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
Revision as of 13:48, 2 March 2016
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Medical Therapy
In case of seminoma, the healthcare team creates an individualized treatment plan. It is generally based on the patient's needs and may include a combination of different treatments. The factors which help in deciding the treatment plan for seminoma include:[1]
- Stage of seminoma
- Risk of recurrence
- Fertility
- Preferences of the individual
The various treatment options depending on the stage and recurrence risk of seminoma are discussed below.[2][3][4][5][6]
Treatment of Seminoma | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Stage I | Stage II | Stage III | Recurrent | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Chemotherapy
- Chemotherapy is a common treatment for all stages of seminoma. It is usually given after an orchiectomy. A combination of chemotherapy drugs is usually given.[7]
- BEP is the main chemotherapy combination used for seminoma. It includes bleomycin, etoposide, and cisplatin.
- Sometimes, physicians just give etoposide and cisplatin (called EP). EP is given when bleomycin affects the lungs (called pulmonary toxicity), or there is a high risk that it will cause lung damage.
- High-dose chemotherapy and stem cell transplant may be used for recurrent testicular cancer, if the standard-dose chemotherapy doesn’t work and the cancer comes back.
- High doses of carboplatin and etoposide are given. After high-dose chemotherapy, a stem cell transplant is done to replace the stem cells that are damaged or destroyed by high-dose chemotherapy. The stem cell transplant is an autologous peripheral blood stem cell transplant.[7]
References
- ↑ Treatments for testicular cancer. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/?region=on. Accessed on March 1, 2016
- ↑ Treatment for testicular cancer. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/?region=on. Accessed on March 1, 2016
- ↑ Treatments for stage I seminoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/seminoma/stage-i/?region=on. Accessed on March 1, 2016
- ↑ Treatments for stage II seminoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/seminoma/stage-ii/?region=on. Accessed on March 1, 2016
- ↑ Treatments for stage III seminoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/seminoma/stage-iii/?region=on. Accessed on March 1, 2016
- ↑ Treatments for recurrent seminoma. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/seminoma/recurrent/?region=on. Accessed on March 1, 2016
- ↑ 7.0 7.1 Treatments for testicular cancer. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/testicular/treatment/?region=on. Accessed on March 2, 2016