Sandbox lung cancer differential: Difference between revisions
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| rowspan=" | | rowspan="5" |'''Large cell carcinoma''' | ||
| colspan="2" | | | colspan="2" |Basaloid large cell carcinoma of the lung | ||
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| rowspan=" | * Approximately 10% of lung cancers. | ||
* Smoking | |||
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* Neuro endocrine cells | * Neuro endocrine cells | ||
* Suprabasal bronchial cells. | * Suprabasal bronchial cells. | ||
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* | *Invasive growth pattern | ||
| rowspan=" | *Peripheral palisading | ||
*Small, monomorphic, cuboidal fusiform | |||
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* Soft, pink-tan tumor | * Soft, pink-tan tumor | ||
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* Cavitations. | * Cavitations. | ||
* Exophytic bronchial growth | * Exophytic bronchial growth | ||
| rowspan=" | | rowspan="5" | | ||
*[[Chromogranin]] | *[[Chromogranin]] | ||
*[[Synaptophysin]] | *[[Synaptophysin]] | ||
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*EBER-1 RNA + | *EBER-1 RNA + | ||
*Cytokeratin | *Cytokeratin | ||
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* Large, peripheral masses | * Large, peripheral masses | ||
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* Pleura | * Pleura | ||
* Liver | * Liver | ||
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* Abdominal lymph nodes | * Abdominal lymph nodes | ||
* Pericardium | * Pericardium | ||
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| colspan="2" |Clear cell carcinoma of the lung | | colspan="2" |Clear cell carcinoma of the lung | ||
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| colspan="2" |Lymphoepithelioma-like carcinoma of the lung | | colspan="2" |Lymphoepithelioma-like carcinoma of the lung | ||
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| colspan="2" |Large-cell lung carcinoma with rhabdoid phenotype | | colspan="2" |Large-cell lung carcinoma with rhabdoid phenotype | ||
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| colspan="2" |Mixed type | | colspan="2" |Mixed type | ||
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Revision as of 01:24, 8 March 2018
- Differentiation of primary and secondary lun tumors is difficult due to overlapping histologic features.
- Topography, size and form of pulmonary growth pattern are important aspects for the differential diagnosis.
- Primary lung tumors are mainly localized in upper lobes as singular nodules, metastases in lower lobes as multiple lesions.
- On the contarary, endobronchial primary or secondary squamous cell carcinomas findings of severe dysplasia and CIS of the bronchial epithelium are important.
- Stroma and vascularisation pattern of primary and secondary lung tumors differ in distribution, arrangement and extracellular matrix components.
- Pulmonary vascular changes in primary tumors are characterized by vascular infiltration, destruction and occlusion whereas in secondary tumors intravascular embolisation and extravasation predominate.
Malignant lung carcnimoma | ||||||||||
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Risk Factors/Epidemiology | Pleuripotent cell | Topography | Histology | Gross | Immunohistochemistry | Imaging | Mets | |||
Squamous cell carcinoma | Papillary |
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Clear cell |
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Small cell |
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Basaloid |
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Small cell carcinoma |
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Adeno carcinoma | Adenocarcinoma, mixed sub type |
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Aerogenous spread is characteristic
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Acinar adenocarcinoma | ||||||||||
Papillary adenocarcinoma |
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Bronchio-alveolar carcinoma | Non-mucinous |
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Mucinous |
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Mixed non-mucinous and mucinous or indeterminate | ||||||||||
Solid adenocarcinoma with mucin production | Fetal adenocarcinoma |
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Mucinous (“colloid”) carcinoma |
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Mucinous cystadenocarcinoma |
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Signet ring adenocarcinoma | ||||||||||
Clear cell adenocarcinoma | ||||||||||
Large cell carcinoma | Basaloid large cell carcinoma of the lung |
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Clear cell carcinoma of the lung |
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Lymphoepithelioma-like carcinoma of the lung |
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Large-cell lung carcinoma with rhabdoid phenotype |
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Mixed type |
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Sarcomatoid carcinoma | Carcinosarcoma |
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Spindle cell carcinoma |
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Giant cell carcinoma |
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Pleomorphic carcinoma |
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Pulmonary blastoma |
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Carcinoid tumour | Typical carcinoid
Atypical carcinoid |
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Salivary gland tumours | Mucoepidermoid carcinoma |
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Adenoid cystic carcinoma |
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Epithelial-myoepithelial carcinoma |
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Preinvasive lesions | Squamous carcinoma in situ |
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Atypical adenomatous hyperplasia |
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Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia |
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Mesenchymal tumors | Epithelioid haemangioendothelioma / Angiosarcoma |
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Pleuropulmonary blastoma |
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Chondroma |
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Congenital peribronchial myofibroblastic tumor |
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Diffuse pulmonary lymphangiomatosis |
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Inflammatory myofibroblastic tumor |
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Pulmonary artery sarcoma |
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Pulmonary vein sarcoma |
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Benign lung tumor | ||||||||
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Risk factors | Gross pathology | Histopathology | Immunohistochemistry | Topography | Prognosis | |||
Papilloma | Squamous cell papilloma | Exophytic and Inverted |
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N/A |
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Glandular papilloma | Not specific |
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N/A |
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Mixed squamous cell and glandular papilloma |
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N/A |
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Adenomas | Alveolar adenoma | |||||||
Papillary adenoma | ||||||||
Adenomas of the salivary gland type | Mucous gland adenoma | |||||||
Pleomorphic adenoma | ||||||||
Mucinous cystadenoma | ||||||||
Lymphoproliferative tumors | Marginal zone B-cell lymphoma of the MALT type | |||||||
Diffuse large B-cell lymphoma | ||||||||
Lymphomatoid granulomatosis | ||||||||
Langerhans cell histiocytosis | ||||||||
Miscellaneous tumors | Harmatoma | |||||||
Sclerosing hemangioma | ||||||||
Clear cell tumor | ||||||||
Germ cell tumors | Mature tratoma | |||||||
Immature teratoma | ||||||||
Other germ cell tumours | ||||||||
Intrapulmonary thymoma | ||||||||
Melanoma | ||||||||
Metastatic tumors |