Sandbox: malabsorption

Revision as of 18:56, 7 November 2017 by Ssharfaei (talk | contribs)
Jump to navigation Jump to search

Abbreviations: WBC: White blood cells; Plt: Platelets, Hgb: Hemoglobin, IgE: Immunoglobulin E, IgA: Immunoglobulin A

Cause Peak age of onset History Physical exam Lab findings Additional findings Cause/Pathogenesis Gold standard diagnosis
Fever Abdominal pain Diarrhea Weight loss
Watery Fatty WBC Hgb Plt Other lab findings
Whipple's disease 50th +/- + + + + ↓/↑
Celiac disease Childhood

Adult

+/- +/- - + + - -
  • IgA endomysial antibody
  • Anti-tissue transglutaminase antibody
  • Anti-gliadin antibody
  • IgA endomysial antibody
  • IgA tissue transglutaminase antibody
Grain allergy Childhood + - - + +
Cystic fibrosis Infancy and childhood - + + +
  • Positive DNA analysis for CFTR multimutation method
  • Evaluated nasal transepithelial potential difference (NPD)
Lactose intolerance Adult + - - +
  • Stool osmotic gap of >125 mOsm/kg 
  • Stool pH <6 
Crohns disease Young adults

(20th)

+ - + +
  • Abnormal immune response to self antigens
Laxative overuse After childhood + - +/- +/- -
Hyperthyroidism Any age + - + +/-
  • Elevated T4
  • Elevated T3
  • Decreased level of TSH
Irritable bowel syndrome Between 30 and 50 + - - + -
VIPoma Between 30 and 50 + - + +/-
  • Primary secretory tumor
  • Elevated VIP levels
  • Followed by imaging
Gastrinoma (Zollinger-Ellison syndrome) Between the ages of 20 and 50 + - + +
  • Elevated basal or stimulated serum gastrin more than 1000 pg/mL
Lactose intolerance Any age - + + +/-
Allergic enteropathy/Food protein-induced enterocolitis syndrome (FPIES) Infancy + - +/- + Stool examination:
  • Triggered by cow milk protein
  • Profuse, repetitive vomiting
  • Oral food challenge (OFC)
Eosinophilic gastroenteritis  30th + - +/- +
Primary bile acid malabsorption Childhood Adolescents + +/- + +/- -
Abetalipoproteinemia Infancy - + + +
Microscopic colitis 60th + - + +