SSX1: Difference between revisions

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{{Infobox_gene}}
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'''Protein SSX1''' is a [[protein]] that in humans is encoded by the ''SSX1'' [[gene]].<ref name="pmid7655467">{{cite journal | vauthors = de Leeuw B, Balemans M, Olde Weghuis D, Geurts van Kessel A | title = Identification of two alternative fusion genes, SYT-SSX1 and SYT-SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas | journal = Hum Mol Genet | volume = 4 | issue = 6 | pages = 1097–9 |date=Oct 1995 | pmid = 7655467 | pmc =  | doi =10.1093/hmg/4.6.1097 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SSX1 synovial sarcoma, X breakpoint 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6756| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Synovial sarcoma, X breakpoint 1
| HGNCid = 11335
| Symbol = SSX1
| AltSymbols =; MGC150425; MGC5162; SSRC
| OMIM = 312820
| ECnumber = 
| Homologene = 88725
| MGIid = 
| GeneAtlas_image1 = PBB_GE_SSX1_206627_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SSX1_206626_x_at_tn.png
| GeneAtlas_image3 = PBB_GE_SSX1_210394_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6756
    | Hs_Ensembl = ENSG00000126752
    | Hs_RefseqProtein = XP_001127510
    | Hs_RefseqmRNA = XM_001127510
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 47999696
    | Hs_GenLoc_end = 48011823
    | Hs_Uniprot = Q16384
    | Mm_EntrezGene =   
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot =   
  }}
}}
'''Synovial sarcoma, X breakpoint 1''', also known as '''SSX1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SSX1 synovial sarcoma, X breakpoint 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6756| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The product of this gene belongs to the family of highly homologous synovial sarcoma X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity.<ref name="entrez">{{cite web | title = Entrez Gene: SSX1 synovial sarcoma, X breakpoint 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6756| accessdate = }}</ref>
| summary_text = The product of this gene belongs to the family of highly homologous [[Synovial sarcoma, X breakpoint|synovial sarcoma, X (SSX) breakpoint]] proteins. These proteins may function as transcriptional [[repressor]]s. They are also capable of eliciting spontaneously [[humoral immunity|humoral]] and [[cell-mediated immunity|cellular immune responses]] in cancer patients, and are potentially useful targets in [[cancer vaccine|cancer vaccine-based immunotherapy]]. SSX1, [[SSX2]] and [[SSX4 (gene)|SSX4]] genes have been involved in the t(X;18) [[chromosomal translocation]] characteristically found in all [[synovial sarcoma]]s. This translocation results in the fusion of the synovial sarcoma translocation gene on [[chromosome 18]] to one of the SSX genes on [[chromosome X]]. The encoded hybrid proteins are probably responsible for transforming activity.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Crew AJ, Clark J, Fisher C, ''et al.'' |title=Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma. |journal=EMBO J. |volume=14 |issue= 10 |pages= 2333-40 |year= 1995 |pmid= 7539744 |doi=  }}
*{{cite journal   |vauthors=Crew AJ, Clark J, Fisher C, etal |title=Fusion of SYT to two genes, SSX1 and SSX2, encoding proteins with homology to the Kruppel-associated box in human synovial sarcoma |journal=EMBO J. |volume=14 |issue= 10 |pages= 2333–40 |year= 1995 |pmid= 7539744 |doi=  | pmc=398342 }}
*{{cite journal  | author=de Leeuw B, Balemans M, Olde Weghuis D, Geurts van Kessel A |title=Identification of two alternative fusion genes, SYT-SSX1 and SYT-SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas. |journal=Hum. Mol. Genet. |volume=4 |issue= 6 |pages= 1097-9 |year= 1995 |pmid= 7655467 |doi=  }}
*{{cite journal   |vauthors=Clark J, Rocques PJ, Crew AJ, etal |title=Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma |journal=Nat. Genet. |volume=7 |issue= 4 |pages= 502–8 |year= 1994 |pmid= 7951320 |doi= 10.1038/ng0894-502 }}
*{{cite journal | author=Clark J, Rocques PJ, Crew AJ, ''et al.'' |title=Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma. |journal=Nat. Genet. |volume=7 |issue= 4 |pages= 502-8 |year= 1994 |pmid= 7951320 |doi= 10.1038/ng0894-502 }}
*{{cite journal   |vauthors=Sinke RJ, de Leeuw B, Janssen HA, etal |title=Localization of X chromosome short arm markers relative to synovial sarcoma- and renal adenocarcinoma-associated translocation breakpoints |journal=Hum. Genet. |volume=92 |issue= 3 |pages= 305–8 |year= 1993 |pmid= 8406438 |doi=10.1007/BF00244478 }}
*{{cite journal | author=Sinke RJ, de Leeuw B, Janssen HA, ''et al.'' |title=Localization of X chromosome short arm markers relative to synovial sarcoma- and renal adenocarcinoma-associated translocation breakpoints. |journal=Hum. Genet. |volume=92 |issue= 3 |pages= 305-8 |year= 1993 |pmid= 8406438 |doi=  }}
*{{cite journal  | vauthors=Chand A, Clark J, Cooper CS, Craig IW |title=Long-range organization of reiterated sequences, including the SSX1 cDNA at the OATL1 cluster in Xp11.23 |journal=Genomics |volume=30 |issue= 3 |pages= 545–52 |year= 1997 |pmid= 8825641 |doi= 10.1006/geno.1995.1275 }}
*{{cite journal  | author=Chand A, Clark J, Cooper CS, Craig IW |title=Long-range organization of reiterated sequences, including the SSX1 cDNA at the OATL1 cluster in Xp11.23. |journal=Genomics |volume=30 |issue= 3 |pages= 545-52 |year= 1997 |pmid= 8825641 |doi= 10.1006/geno.1995.1275 }}
*{{cite journal   |vauthors=Thaete C, Brett D, Monaghan P, etal |title=Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus |journal=Hum. Mol. Genet. |volume=8 |issue= 4 |pages= 585–91 |year= 1999 |pmid= 10072425 |doi=10.1093/hmg/8.4.585 }}
*{{cite journal | author=Thaete C, Brett D, Monaghan P, ''et al.'' |title=Functional domains of the SYT and SYT-SSX synovial sarcoma translocation proteins and co-localization with the SNF protein BRM in the nucleus. |journal=Hum. Mol. Genet. |volume=8 |issue= 4 |pages= 585-91 |year= 1999 |pmid= 10072425 |doi=  }}
*{{cite journal   |vauthors=Kato H, Tjernberg A, Zhang W, etal |title=SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5498–505 |year= 2002 |pmid= 11734557 |doi= 10.1074/jbc.M108702200 }}
*{{cite journal | author=Kato H, Tjernberg A, Zhang W, ''et al.'' |title=SYT associates with human SNF/SWI complexes and the C-terminal region of its fusion partner SSX1 targets histones. |journal=J. Biol. Chem. |volume=277 |issue= 7 |pages= 5498-505 |year= 2002 |pmid= 11734557 |doi= 10.1074/jbc.M108702200 }}
*{{cite journal   |vauthors=de Bruijn DR, dos Santos NR, Kater-Baats E, etal |title=The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP |journal=Genes Chromosomes Cancer |volume=34 |issue= 3 |pages= 285–98 |year= 2002 |pmid= 12007189 |doi= 10.1002/gcc.10073 }}
*{{cite journal | author=de Bruijn DR, dos Santos NR, Kater-Baats E, ''et al.'' |title=The cancer-related protein SSX2 interacts with the human homologue of a Ras-like GTPase interactor, RAB3IP, and a novel nuclear protein, SSX2IP. |journal=Genes Chromosomes Cancer |volume=34 |issue= 3 |pages= 285-98 |year= 2002 |pmid= 12007189 |doi= 10.1002/gcc.10073 }}
*{{cite journal   |vauthors=Yang K, Lui WO, Xie Y, etal |title=Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas |journal=Oncogene |volume=21 |issue= 26 |pages= 4181–90 |year= 2002 |pmid= 12037676 |doi= 10.1038/sj.onc.1205569 }}
*{{cite journal | author=Yang K, Lui WO, Xie Y, ''et al.'' |title=Co-existence of SYT-SSX1 and SYT-SSX2 fusions in synovial sarcomas. |journal=Oncogene |volume=21 |issue= 26 |pages= 4181-90 |year= 2002 |pmid= 12037676 |doi= 10.1038/sj.onc.1205569 }}
*{{cite journal  | vauthors=Güre AO, Wei IJ, Old LJ, Chen YT |title=The SSX gene family: characterization of 9 complete genes |journal=Int. J. Cancer |volume=101 |issue= 5 |pages= 448–53 |year= 2002 |pmid= 12216073 |doi= 10.1002/ijc.10634 }}
*{{cite journal  | author=Güre AO, Wei IJ, Old LJ, Chen YT |title=The SSX gene family: characterization of 9 complete genes. |journal=Int. J. Cancer |volume=101 |issue= 5 |pages= 448-53 |year= 2002 |pmid= 12216073 |doi= 10.1002/ijc.10634 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Storlazzi CT, Mertens F, Mandahl N, etal |title=A novel fusion gene, SS18L1/SSX1, in synovial sarcoma |journal=Genes Chromosomes Cancer |volume=37 |issue= 2 |pages= 195–200 |year= 2003 |pmid= 12696068 |doi= 10.1002/gcc.10210 }}
*{{cite journal | author=Storlazzi CT, Mertens F, Mandahl N, ''et al.'' |title=A novel fusion gene, SS18L1/SSX1, in synovial sarcoma. |journal=Genes Chromosomes Cancer |volume=37 |issue= 2 |pages= 195-200 |year= 2003 |pmid= 12696068 |doi= 10.1002/gcc.10210 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Tvrdík D, Povýsil C, Svatosová J, Dundr P |title=Molecular diagnosis of synovial sarcoma: RT-PCR detection of SYT-SSX1/2 fusion transcripts in paraffin-embedded tissue |journal=Med. Sci. Monit. |volume=11 |issue= 3 |pages= MT1–7 |year= 2005 |pmid= 15735574 |doi=  }}
*{{cite journal  | author=Tvrdík D, Povýsil C, Svatosová J, Dundr P |title=Molecular diagnosis of synovial sarcoma: RT-PCR detection of SYT-SSX1/2 fusion transcripts in paraffin-embedded tissue. |journal=Med. Sci. Monit. |volume=11 |issue= 3 |pages= MT1-7 |year= 2005 |pmid= 15735574 |doi=  }}
*{{cite journal   |vauthors=Ross MT, Grafham DV, Coffey AJ, etal |title=The DNA sequence of the human X chromosome |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 | pmc=2665286 }}
*{{cite journal | author=Ross MT, Grafham DV, Coffey AJ, ''et al.'' |title=The DNA sequence of the human X chromosome. |journal=Nature |volume=434 |issue= 7031 |pages= 325-37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 }}
*{{cite journal   |vauthors=Fernebro J, Francis P, Edén P, etal |title=Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma |journal=Int. J. Cancer |volume=118 |issue= 5 |pages= 1165–72 |year= 2006 |pmid= 16152617 |doi= 10.1002/ijc.21475 }}
*{{cite journal | author=Fernebro J, Francis P, Edén P, ''et al.'' |title=Gene expression profiles relate to SS18/SSX fusion type in synovial sarcoma. |journal=Int. J. Cancer |volume=118 |issue= 5 |pages= 1165-72 |year= 2006 |pmid= 16152617 |doi= 10.1002/ijc.21475 }}
*{{cite journal   |vauthors=Sun Y, Gao D, Liu Y, etal |title=IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1 |journal=Oncogene |volume=25 |issue= 7 |pages= 1042–52 |year= 2006 |pmid= 16247461 |doi= 10.1038/sj.onc.1209143 }}
*{{cite journal | author=Sun Y, Gao D, Liu Y, ''et al.'' |title=IGF2 is critical for tumorigenesis by synovial sarcoma oncoprotein SYT-SSX1. |journal=Oncogene |volume=25 |issue= 7 |pages= 1042-52 |year= 2006 |pmid= 16247461 |doi= 10.1038/sj.onc.1209143 }}
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{{gene-X-stub}}

Latest revision as of 07:06, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein SSX1 is a protein that in humans is encoded by the SSX1 gene.[1][2]

The product of this gene belongs to the family of highly homologous synovial sarcoma, X (SSX) breakpoint proteins. These proteins may function as transcriptional repressors. They are also capable of eliciting spontaneously humoral and cellular immune responses in cancer patients, and are potentially useful targets in cancer vaccine-based immunotherapy. SSX1, SSX2 and SSX4 genes have been involved in the t(X;18) chromosomal translocation characteristically found in all synovial sarcomas. This translocation results in the fusion of the synovial sarcoma translocation gene on chromosome 18 to one of the SSX genes on chromosome X. The encoded hybrid proteins are probably responsible for transforming activity.[2]

References

  1. ↑ de Leeuw B, Balemans M, Olde Weghuis D, Geurts van Kessel A (Oct 1995). "Identification of two alternative fusion genes, SYT-SSX1 and SYT-SSX2, in t(X;18)(p11.2;q11.2)-positive synovial sarcomas". Hum Mol Genet. 4 (6): 1097–9. doi:10.1093/hmg/4.6.1097. PMID 7655467.
  2. ↑ 2.0 2.1 "Entrez Gene: SSX1 synovial sarcoma, X breakpoint 1".

Further reading



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