SLU7: Difference between revisions
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'''Pre-mRNA-splicing factor SLU7''' is a [[protein]] that in humans is encoded by the ''SLU7'' [[gene]].<ref name="pmid10197984">{{cite journal | vauthors = Chua K, Reed R | title = Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing | journal = Genes Dev | volume = 13 | issue = 7 | pages = 841–50 |date=May 1999 | pmid = 10197984 | pmc = 316594 | doi =10.1101/gad.13.7.841 }}</ref><ref name="pmid15728250">{{cite journal | vauthors = Shomron N, Alberstein M, Reznik M, Ast G | title = Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing | journal = J Cell Sci | volume = 118 | issue = Pt 6 | pages = 1151–9 |date=Mar 2005 | pmid = 15728250 | pmc = | doi = 10.1242/jcs.01720 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLU7 SLU7 splicing factor homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10569| accessdate = }}</ref> | '''Pre-mRNA-splicing factor SLU7''' is a [[protein]] that in humans is encoded by the ''SLU7'' [[gene]].<ref name="pmid10197984">{{cite journal | vauthors = Chua K, Reed R | title = Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing | journal = Genes Dev | volume = 13 | issue = 7 | pages = 841–50 |date=May 1999 | pmid = 10197984 | pmc = 316594 | doi =10.1101/gad.13.7.841 }}</ref><ref name="pmid15728250">{{cite journal | vauthors = Shomron N, Alberstein M, Reznik M, Ast G | title = Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing | journal = J Cell Sci | volume = 118 | issue = Pt 6 | pages = 1151–9 |date=Mar 2005 | pmid = 15728250 | pmc = | doi = 10.1242/jcs.01720 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLU7 SLU7 splicing factor homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10569| accessdate = }}</ref> | ||
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| summary_text = Pre- | | summary_text = [[Pre-mRNA]] splicing occurs in two sequential [[transesterification]] steps. The protein encoded by this gene is a [[splicing factor]] that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the [[spliceosome]] and contains a zinc knuckle [[sequence motif|motif]] that is found in other splicing factors and is involved in protein-nucleic acid and [[protein-protein interactions]].<ref name="entrez">{{cite web | title = Entrez Gene: SLU7 SLU7 splicing factor homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10569| accessdate = }}</ref> | ||
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Latest revision as of 21:41, 19 February 2018
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Pre-mRNA-splicing factor SLU7 is a protein that in humans is encoded by the SLU7 gene.[1][2][3]
Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions.[3]
References
- ↑ Chua K, Reed R (May 1999). "Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing". Genes Dev. 13 (7): 841–50. doi:10.1101/gad.13.7.841. PMC 316594. PMID 10197984.
- ↑ Shomron N, Alberstein M, Reznik M, Ast G (Mar 2005). "Stress alters the subcellular distribution of hSlu7 and thus modulates alternative splicing". J Cell Sci. 118 (Pt 6): 1151–9. doi:10.1242/jcs.01720. PMID 15728250.
- ↑ 3.0 3.1 "Entrez Gene: SLU7 SLU7 splicing factor homolog (S. cerevisiae)".
Further reading
- Alberstein M, Amit M, Vaknin K, et al. (2008). "Regulation of transcription of the RNA splicing factor hSlu7 by Elk-1 and Sp1 affects alternative splicing". RNA. 13 (11): 1988–99. doi:10.1261/rna.492907. PMC 2040095. PMID 17804646.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
- Shomron N, Reznik M, Ast G (2005). "Splicing factor hSlu7 contains a unique functional domain required to retain the protein within the nucleus". Mol. Biol. Cell. 15 (8): 3782–95. doi:10.1091/mbc.E04-02-0152. PMC 491837. PMID 15181151.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Chua K, Reed R (2001). "An upstream AG determines whether a downstream AG is selected during catalytic step II of splicing". Mol. Cell. Biol. 21 (5): 1509–14. doi:10.1128/MCB.21.5.1509-1514.2001. PMC 86697. PMID 11238888.
- Chua K, Reed R (2000). "The RNA splicing factor hSlu7 is required for correct 3' splice-site choice". Nature. 402 (6758): 207–10. doi:10.1038/46086. PMID 10647016.
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