Rhabdomyosarcoma natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Shadan Mehraban, M.D.[2]

Overview

Common complications of rhabdomyosarcoma include metastasis to lung, bone marrow, and bone. Rhabdomyosarcoma is associated with a 5 year survival rate of 72%. The presence of metastasis is associated with a particularly poor prognosis. Histologically, the embryonal type rhabdomyosarcoma and anatomically, the orbital and genitourinary tract rhabdomyosarcomas have the most favorable prognosis.

Complications

  • Rhabdomyosarcoma may cause metastasis to other organs.[1]
    • Less than 25% of patients present with distant metastases at he time of diagnosis.[2]
    • The common metastatic site is lung.
    • The other metastatic sites are as following:[3][4]
      • Bone marrow (30%)
      • Bone (30%)
      • Omentum and ascites (16%)
      • Pleura (13%)
      • Visceral involvement
      • brain metastases
  • Patients may develop with some complications after treatment such as:[5]
    • Cardiomyopathy
      • Regarding anthracycline and cyclophosphamide use
    • Pulmonary failure
    • Renal electrolyte wasting
      • Regarding ifosfamide use
    • Acute myelogenous leukemia
      • Regarding etoposide use
    • Secondary malignancies
      • Skin and bone tumors regarding radiotherapy
  • Long-term complications after treatment
    • Common long-term complications are as following:
      • Short stature and facial asymmetry
      • Poor dentition
      • Impaired hearing, vision, and learning
  • Specific long-term complications of different tumor sites are listed below.

Prognosis

  • Rhabdomyosarcoma is associated with a 5 year survival rate of 72%.
  • The presence of metastasis is associated with a particularly poor prognosis among patients with rhabdomyosarcoma. The 5 year event free survival rate is less than 30%.
  • Histologically, the embryonal type rhabdomyosarcoma and anatomically, the orbital and genitourinary tract rhabdomyosarcomas have the most favorable prognosis.

References

  1. Raney RB, Tefft M, Maurer HM, Ragab AH, Hays DM, Soule EH; et al. (1988). "Disease patterns and survival rate in children with metastatic soft-tissue sarcoma. A report from the Intergroup Rhabdomyosarcoma Study (IRS)-I". Cancer. 62 (7): 1257–66. PMID 2843274.
  2. Koscielniak E, Rodary C, Flamant F, Carli M, Treuner J, Pinkerton CR; et al. (1992). "Metastatic rhabdomyosarcoma and histologically similar tumors in childhood: a retrospective European multi-center analysis". Med Pediatr Oncol. 20 (3): 209–14. PMID 1574030.
  3. Ruymann FB, Newton WA, Ragab AH, Donaldson MH, Foulkes M (1984). "Bone marrow metastases at diagnosis in children and adolescents with rhabdomyosarcoma. A report from the intergroup rhabdomyosarcoma study". Cancer. 53 (2): 368–73. PMID 6546301.
  4. Breneman JC, Lyden E, Pappo AS, Link MP, Anderson JR, Parham DM; et al. (2003). "Prognostic factors and clinical outcomes in children and adolescents with metastatic rhabdomyosarcoma--a report from the Intergroup Rhabdomyosarcoma Study IV". J Clin Oncol. 21 (1): 78–84. doi:10.1200/JCO.2003.06.129. PMID 12506174.
  5. Punyko JA, Mertens AC, Gurney JG, Yasui Y, Donaldson SS, Rodeberg DA; et al. (2005). "Long-term medical effects of childhood and adolescent rhabdomyosarcoma: a report from the childhood cancer survivor study". Pediatr Blood Cancer. 44 (7): 643–53. doi:10.1002/pbc.20310. PMID 15700252.

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