Rhabdomyosarcoma classification: Difference between revisions
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**Botryoid and spindle cell (leiomyomatous) RMS | **Botryoid and spindle cell (leiomyomatous) RMS | ||
**Sclerosing and spindle cell RMS | **Sclerosing and spindle cell RMS | ||
*Separate categories for other subtypes which do not classify into above groups: | *Separate categories for other subtypes which do not classify into above groups:<ref name="pmid8470759">{{cite journal| author=Kodet R, Newton WA, Hamoudi AB, Asmar L, Jacobs DL, Maurer HM| title=Childhood rhabdomyosarcoma with anaplastic (pleomorphic) features. A report of the Intergroup Rhabdomyosarcoma Study. | journal=Am J Surg Pathol | year= 1993 | volume= 17 | issue= 5 | pages= 443-53 | pmid=8470759 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=8470759 }}</ref> | ||
**Undifferentiated | **Undifferentiated | ||
**Pleomorphic/anaplastic | **Pleomorphic/anaplastic | ||
**Sarcoma | **Sarcoma, not otherwise specified (NOS) | ||
{| class="wikitable" | {| class="wikitable" | ||
|+ | |+ |
Revision as of 19:39, 11 January 2019
Rhabdomyosarcoma Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Shadan Mehraban, M.D.[2]
Overview
Classification
Histologic classification of rhabdomyosarcoma
- The international classification of rhabdomyosarcoma (RMS) was created by the Intergroup Rhabdomyosarcoma Study group (IRSG) therapeutic trials (IRS-I to IV).[1][2]
- The four main subgroups are:
- Embryonal rhabdomyosarcoma (ERMS)
- Alveolar rhabdomyosarcoma (ARMS)
- Botryoid and spindle cell (leiomyomatous) RMS
- Sclerosing and spindle cell RMS
- Separate categories for other subtypes which do not classify into above groups:[3]
- Undifferentiated
- Pleomorphic/anaplastic
- Sarcoma, not otherwise specified (NOS)
RMS subtypes | Definition |
---|---|
Embryonal RMS (ERMS) |
|
Alveolar RMS (ARMS) |
|
Botryoid and spindle cell RMS |
|
Sclerosing RMS |
|
Anaplastic RMS |
|
References
- ↑ Qualman SJ, Coffin CM, Newton WA, Hojo H, Triche TJ, Parham DM; et al. (1998). "Intergroup Rhabdomyosarcoma Study: update for pathologists". Pediatr Dev Pathol. 1 (6): 550–61. PMID 9724344.
- ↑ Hicks J, Flaitz C (2002). "Rhabdomyosarcoma of the head and neck in children". Oral Oncol. 38 (5): 450–9. PMID 12110339.
- ↑ Kodet R, Newton WA, Hamoudi AB, Asmar L, Jacobs DL, Maurer HM (1993). "Childhood rhabdomyosarcoma with anaplastic (pleomorphic) features. A report of the Intergroup Rhabdomyosarcoma Study". Am J Surg Pathol. 17 (5): 443–53. PMID 8470759.
- ↑ De Giovanni C, Landuzzi L, Nicoletti G, Lollini PL, Nanni P (2009). "Molecular and cellular biology of rhabdomyosarcoma". Future Oncol. 5 (9): 1449–75. doi:10.2217/fon.09.97. PMID 19903072.
- ↑ Scrable HJ, Witte DP, Lampkin BC, Cavenee WK (1987). "Chromosomal localization of the human rhabdomyosarcoma locus by mitotic recombination mapping". Nature. 329 (6140): 645–7. doi:10.1038/329645a0. PMID 3657988.
- ↑ Helman LJ, Meltzer P (2003). "Mechanisms of sarcoma development". Nat Rev Cancer. 3 (9): 685–94. doi:10.1038/nrc1168. PMID 12951587.
- ↑ Hettmer S, Archer NM, Somers GR, Novokmet A, Wagers AJ, Diller L; et al. (2014). "Anaplastic rhabdomyosarcoma in TP53 germline mutation carriers". Cancer. 120 (7): 1068–75. doi:10.1002/cncr.28507. PMC 4173134. PMID 24382691.