Rhabdomyosarcoma classification: Difference between revisions
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**Alveolar rhabdomyosarcoma (ARMS) | **Alveolar rhabdomyosarcoma (ARMS) | ||
**Botryoid and spindle cell (leiomyomatous) RMS | **Botryoid and spindle cell (leiomyomatous) RMS | ||
**Sclerosing and spindle cell RMS | **Sclerosing and spindle cell RMS with MyoD1 mutation | ||
*Separate categories for other subtypes which do not classify into above groups: | *Separate categories for other subtypes which do not classify into above groups: | ||
**Undifferentiated | **Undifferentiated | ||
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* Mostly occur in the trunk and extremities | * Mostly occur in the trunk and extremities | ||
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|Botryoid and spindle cell | |Botryoid and spindle cell RMS | ||
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* Botryoid RMS contain 6% of all RMS | |||
* Spindle cell RMS contains 3% of all RMS | |||
* Less common varients of ERMS | |||
* Accompanied with more favorable prognosis | |||
* Botryoid name related to grape-like appearance of tumor | |||
* Botryoid RMS occur within bladder wall and vagina | |||
* Spindle cell is prevalent among infants and neonates under age of 1 years old | |||
* Spindle cell RMS occurs in paratesticular location | |||
|- | |||
|Sclerosing and spindle cell RMS | |||
| | |||
* Less common variants of ERMS | |||
* Poor outcome | |||
* | |||
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Revision as of 19:04, 11 January 2019
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Rhabdomyosarcoma Microchapters |
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Rhabdomyosarcoma classification On the Web |
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American Roentgen Ray Society Images of Rhabdomyosarcoma classification |
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Risk calculators and risk factors for Rhabdomyosarcoma classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Shadan Mehraban, M.D.[2]
Overview
Classification
Histologic classification of rhabdomyosarcoma
- The international classification of rhabdomyosarcoma (RMS) was created by the Intergroup Rhabdomyosarcoma Study group (IRSG) therapeutic trials (IRS-I to IV).[1][2]
- The four main subgroups are:
- Embryonal rhabdomyosarcoma (ERMS)
- Alveolar rhabdomyosarcoma (ARMS)
- Botryoid and spindle cell (leiomyomatous) RMS
- Sclerosing and spindle cell RMS with MyoD1 mutation
- Separate categories for other subtypes which do not classify into above groups:
- Undifferentiated
- Pleomorphic/anaplastic
- Sarcoma
| RMS subtypes | Definition |
|---|---|
| Embryonal RMS (ERMS) |
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| Alveolar RMS (ARMS) |
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| Botryoid and spindle cell RMS |
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| Sclerosing and spindle cell RMS |
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References
- ↑ Qualman SJ, Coffin CM, Newton WA, Hojo H, Triche TJ, Parham DM; et al. (1998). "Intergroup Rhabdomyosarcoma Study: update for pathologists". Pediatr Dev Pathol. 1 (6): 550–61. PMID 9724344.
- ↑ Hicks J, Flaitz C (2002). "Rhabdomyosarcoma of the head and neck in children". Oral Oncol. 38 (5): 450–9. PMID 12110339.
- ↑ De Giovanni C, Landuzzi L, Nicoletti G, Lollini PL, Nanni P (2009). "Molecular and cellular biology of rhabdomyosarcoma". Future Oncol. 5 (9): 1449–75. doi:10.2217/fon.09.97. PMID 19903072.
- ↑ Scrable HJ, Witte DP, Lampkin BC, Cavenee WK (1987). "Chromosomal localization of the human rhabdomyosarcoma locus by mitotic recombination mapping". Nature. 329 (6140): 645–7. doi:10.1038/329645a0. PMID 3657988.
- ↑ Helman LJ, Meltzer P (2003). "Mechanisms of sarcoma development". Nat Rev Cancer. 3 (9): 685–94. doi:10.1038/nrc1168. PMID 12951587.