Rhabdomyosarcoma classification: Difference between revisions
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==Classification== | ==Classification== | ||
Multiple classification systems have been proposed for subclassifying rhabdomyosarcomas. The most recent classification system, the "International Classification of Rhabdomyosarcoma", was created by the Intergroup Rhabdomyosarcoma Study.<ref>{{cite journal |author=Newton WA, Gehan EA, Webber BL, et al. |title=Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification—an Intergroup Rhabdomyosarcoma Study |journal=Cancer |volume=76 |issue=6 |pages=1073–85 |date=September 1995 |pmid=8625211 |doi= 10.1002/1097-0142(19950915)76:6<1073::AID-CNCR2820760624>3.0.CO;2-L }}</ref> This system attempts to combine elements of the previous systems and correlate these with prognosis based on tumor type. Rhabdomyosarcomas classified into six subtypes: | Multiple classification systems have been proposed for subclassifying rhabdomyosarcomas. The most recent classification system, the "International Classification of Rhabdomyosarcoma", was created by the Intergroup Rhabdomyosarcoma Study.<ref>{{cite journal |author=Newton WA, Gehan EA, Webber BL, et al. |title=Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification—an Intergroup Rhabdomyosarcoma Study |journal=Cancer |volume=76 |issue=6 |pages=1073–85 |date=September 1995 |pmid=8625211 |doi= 10.1002/1097-0142(19950915)76:6<1073::AID-CNCR2820760624>3.0.CO;2-L }}</ref> This system attempts to combine elements of the previous systems and correlate these with prognosis based on tumor type. Rhabdomyosarcomas classified into six subtypes: | ||
*Alveolar rhabdomyosarcoma | |||
**Usually affects young adults | |||
**Early [[metastasis]] is common | |||
**Usually arises in regions with [[skeletal muscle]] | |||
*Embryonal rhabdomyosarcoma | |||
**Usually affects children below 10 Years | |||
**Typically locally invasive | |||
**Usually arises in regions without [[skeletal muscle]] | |||
*Botryoid rhabdomyosarcoma | *Botryoid rhabdomyosarcoma | ||
*Spindle cell rhabdomyosarcoma | *Spindle cell rhabdomyosarcoma | ||
*Undifferentiated sarcoma | *Undifferentiated sarcoma | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Classification
Multiple classification systems have been proposed for subclassifying rhabdomyosarcomas. The most recent classification system, the "International Classification of Rhabdomyosarcoma", was created by the Intergroup Rhabdomyosarcoma Study.[1] This system attempts to combine elements of the previous systems and correlate these with prognosis based on tumor type. Rhabdomyosarcomas classified into six subtypes:
- Alveolar rhabdomyosarcoma
- Usually affects young adults
- Early metastasis is common
- Usually arises in regions with skeletal muscle
- Embryonal rhabdomyosarcoma
- Usually affects children below 10 Years
- Typically locally invasive
- Usually arises in regions without skeletal muscle
- Botryoid rhabdomyosarcoma
- Spindle cell rhabdomyosarcoma
- Undifferentiated sarcoma
Several additional subtypes of rhabdomyosarcoma exist that do not fit into the International Classification scheme:
- Pleomorphic rhabdomyosarcoma: Usually occurs in adults rather than children.
- Sclerosing rhabdomyosarcoma: It is a rare rhabdomyosarcoma subtype recently characterized by Folpe, et al.; it is not included in this system.
References
- ↑ Newton WA, Gehan EA, Webber BL; et al. (September 1995). "Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification—an Intergroup Rhabdomyosarcoma Study". Cancer. 76 (6): 1073–85. doi:10.1002/1097-0142(19950915)76:6<1073::AID-CNCR2820760624>3.0.CO;2-L. PMID 8625211.