Rhabdomyosarcoma classification: Difference between revisions
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*Multiple classification systems have been proposed for subclassifying rhabdomyosarcomas. | *Multiple classification systems have been proposed for subclassifying rhabdomyosarcomas. | ||
*The most recent classification system, the "International Classification of Rhabdomyosarcoma", was created by the Intergroup Rhabdomyosarcoma Study.<ref>{{cite journal |author=Newton WA, Gehan EA, Webber BL, et al. |title=Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification—an Intergroup Rhabdomyosarcoma Study |journal=Cancer |volume=76 |issue=6 |pages=1073–85 |date=September 1995 |pmid=8625211 |doi= 10.1002/1097-0142(19950915)76:6<1073::AID-CNCR2820760624>3.0.CO;2-L }}</ref> This system attempts to combine elements of the previous systems and correlate these with prognosis based on tumor type. Rhabdomyosarcomas classified into six subtypes: | *The most recent classification system, the "International Classification of Rhabdomyosarcoma", was created by the Intergroup Rhabdomyosarcoma Study.<ref>{{cite journal |author=Newton WA, Gehan EA, Webber BL, et al. |title=Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification—an Intergroup Rhabdomyosarcoma Study |journal=Cancer |volume=76 |issue=6 |pages=1073–85 |date=September 1995 |pmid=8625211 |doi= 10.1002/1097-0142(19950915)76:6<1073::AID-CNCR2820760624>3.0.CO;2-L }}</ref> This system attempts to combine elements of the previous systems and correlate these with prognosis based on tumor type. Rhabdomyosarcomas classified into six subtypes: | ||
*Botryoid rhabdomyosarcoma | **Botryoid rhabdomyosarcoma | ||
*Spindle cell rhabdomyosarcoma | **Spindle cell rhabdomyosarcoma | ||
*Embryonal rhabdomyosarcoma | **Embryonal rhabdomyosarcoma | ||
*Alveolar rhabdomyosarcoma | **Alveolar rhabdomyosarcoma | ||
*Undifferentiated sarcoma | **Undifferentiated sarcoma | ||
Several additional subtypes of rhabdomyosarcoma exist that do not fit into the International Classification scheme: | *Several additional subtypes of rhabdomyosarcoma exist that do not fit into the International Classification scheme: | ||
*Pleomorphic rhabdomyosarcoma: Usually occurs in adults rather than children. | **Pleomorphic rhabdomyosarcoma: Usually occurs in adults rather than children. | ||
*Sclerosing rhabdomyosarcoma is a rare rhabdomyosarcoma subtype recently characterized by Folpe, ''et al.''; it is not included in this system. | **Sclerosing rhabdomyosarcoma is a rare rhabdomyosarcoma subtype recently characterized by Folpe, ''et al.''; it is not included in this system. | ||
==References== | ==References== |
Revision as of 13:37, 1 September 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Classification
- Multiple classification systems have been proposed for subclassifying rhabdomyosarcomas.
- The most recent classification system, the "International Classification of Rhabdomyosarcoma", was created by the Intergroup Rhabdomyosarcoma Study.[1] This system attempts to combine elements of the previous systems and correlate these with prognosis based on tumor type. Rhabdomyosarcomas classified into six subtypes:
- Botryoid rhabdomyosarcoma
- Spindle cell rhabdomyosarcoma
- Embryonal rhabdomyosarcoma
- Alveolar rhabdomyosarcoma
- Undifferentiated sarcoma
- Several additional subtypes of rhabdomyosarcoma exist that do not fit into the International Classification scheme:
- Pleomorphic rhabdomyosarcoma: Usually occurs in adults rather than children.
- Sclerosing rhabdomyosarcoma is a rare rhabdomyosarcoma subtype recently characterized by Folpe, et al.; it is not included in this system.
References
- ↑ Newton WA, Gehan EA, Webber BL; et al. (September 1995). "Classification of rhabdomyosarcomas and related sarcomas. Pathologic aspects and proposal for a new classification—an Intergroup Rhabdomyosarcoma Study". Cancer. 76 (6): 1073–85. doi:10.1002/1097-0142(19950915)76:6<1073::AID-CNCR2820760624>3.0.CO;2-L. PMID 8625211.