Renal papillary necrosis pathophysiology: Difference between revisions
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==Pathogenesis== | ==Pathogenesis== | ||
* The exact pathogenesis of [[renal papillary necrosis]] is not fully understood. | * The exact pathogenesis of [[renal papillary necrosis]] is not fully understood. | ||
*It is thought that [[Renal papillary necrosis]] is the result of damage to interstitial medullary and papillary cells due to direct effect of diseases such as [[diabetes]], [[sickle cell disease]], [[urinary tract obstruction]], [[renal vein thrombosis]], upper [[urinary tract infection]], [[tuberculosis]], [[vasculitis]], [[renal]] [[transplant rejection]] and long term [[analgesics]] use such as [[acetaminophen]] and [[NSAIDS]]. <ref name="pmid12512867">{{cite journal| author=Brix AE| title=Renal papillary necrosis. | journal=Toxicol Pathol | year= 2002 | volume= 30 | issue= 6 | pages= 672-4 | pmid=12512867 | doi=10.1080/01926230290166760 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12512867 }} </ref><ref name="pmid6394414">{{cite journal| author=Sabatini S| title=Pathophysiology of drug-induced papillary necrosis. | journal=Fundam Appl Toxicol | year= 1984 | volume= 4 | issue= 6 | pages= 909-21 | pmid=6394414 | doi=10.1016/0272-0590(84)90229-x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6394414 }} </ref> | *It is thought that [[Renal papillary necrosis]] is the result of damage to interstitial medullary and papillary cells due to direct effect of diseases such as [[diabetes]], [[sickle cell disease]], [[urinary tract obstruction]], [[renal vein thrombosis]], upper [[urinary tract infection]], [[tuberculosis]], [[vasculitis]], [[renal]] [[transplant rejection]] and long term [[analgesics]] use such as [[acetaminophen]] and [[NSAIDS]]. <ref name="pmid12512867">{{cite journal| author=Brix AE| title=Renal papillary necrosis. | journal=Toxicol Pathol | year= 2002 | volume= 30 | issue= 6 | pages= 672-4 | pmid=12512867 | doi=10.1080/01926230290166760 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12512867 }} </ref><ref name="pmid6394414">{{cite journal| author=Sabatini S| title=Pathophysiology of drug-induced papillary necrosis. | journal=Fundam Appl Toxicol | year= 1984 | volume= 4 | issue= 6 | pages= 909-21 | pmid=6394414 | doi=10.1016/0272-0590(84)90229-x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=6394414 }} </ref><ref name="pmid28584810">{{cite journal| author=Geller SA, de Campos FPF| title=Renal papillary necrosis. | journal=Autops Case Rep | year= 2013 | volume= 3 | issue= 4 | pages= 69-71 | pmid=28584810 | doi=10.4322/acr.2013.042 | pmc=5453664 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28584810 }} </ref> | ||
[[File:Blausen 0592 KidneyAnatomy 01.png|300px|thumb|center|. <ref> By BruceBlaus. When using this image in external sources it can be cited as:Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014". WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436. - Own work, CC BY 3.0, https://commons.wikimedia.org/w/index.php?curid=31118599 </ref>]] | [[File:Blausen 0592 KidneyAnatomy 01.png|300px|thumb|center|. <ref> By BruceBlaus. When using this image in external sources it can be cited as:Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014". WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436. - Own work, CC BY 3.0, https://commons.wikimedia.org/w/index.php?curid=31118599 </ref>]] | ||
* [[Renal]] [[medullary]] and [[papillary]] cells are susceptible to ischemia. <ref name="pmid17102053">{{cite journal| author=Jung DC, Kim SH, Jung SI, Hwang SI, Kim SH| title=Renal papillary necrosis: review and comparison of findings at multi-detector row CT and intravenous urography. | journal=Radiographics | year= 2006 | volume= 26 | issue= 6 | pages= 1827-36 | pmid=17102053 | doi=10.1148/rg.266065039 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17102053 }} </ref> | * [[Renal]] [[medullary]] and [[papillary]] cells are susceptible to [[ischemia]]. <ref name="pmid17102053">{{cite journal| author=Jung DC, Kim SH, Jung SI, Hwang SI, Kim SH| title=Renal papillary necrosis: review and comparison of findings at multi-detector row CT and intravenous urography. | journal=Radiographics | year= 2006 | volume= 26 | issue= 6 | pages= 1827-36 | pmid=17102053 | doi=10.1148/rg.266065039 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17102053 }} </ref> | ||
* [[Medullary cells]] usually produce [[prostaglandins]] and proteoglycans. <ref name="pmid12512867">{{cite journal| author=Brix AE| title=Renal papillary necrosis. | journal=Toxicol Pathol | year= 2002 | volume= 30 | issue= 6 | pages= 672-4 | pmid=12512867 | doi=10.1080/01926230290166760 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12512867 }} </ref> | * [[Medullary cells]] usually produce [[prostaglandins]] and proteoglycans. <ref name="pmid12512867">{{cite journal| author=Brix AE| title=Renal papillary necrosis. | journal=Toxicol Pathol | year= 2002 | volume= 30 | issue= 6 | pages= 672-4 | pmid=12512867 | doi=10.1080/01926230290166760 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12512867 }} </ref> | ||
**Damage of [[medullary cells]] leads to changes in [[renal]] matrix and vessels due to decreased production of [[prostaglandins]] that causes [[vasoconstriction]], reduced [[renal]] perfusion, [[ischemia]] and [[necrosis]]. <ref name="pmid12512867">{{cite journal| author=Brix AE| title=Renal papillary necrosis. | journal=Toxicol Pathol | year= 2002 | volume= 30 | issue= 6 | pages= 672-4 | pmid=12512867 | doi=10.1080/01926230290166760 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12512867 }} </ref><ref name="pmid2362779">{{cite journal| author=Burrell JH, Yong JL, Macdonald GJ| title=Experimental analgesic nephropathy: changes in renal structure and urinary concentrating ability in Fischer 344 rats given continuous low doses of aspirin and paracetamol. | journal=Pathology | year= 1990 | volume= 22 | issue= 1 | pages= 33-44 | pmid=2362779 | doi=10.3109/00313029009061423 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2362779 }} </ref> | **Damage of [[medullary cells]] leads to changes in [[renal]] matrix and vessels due to decreased production of [[prostaglandins]] that causes [[vasoconstriction]], reduced [[renal]] perfusion, [[ischemia]] and [[necrosis]]. <ref name="pmid12512867">{{cite journal| author=Brix AE| title=Renal papillary necrosis. | journal=Toxicol Pathol | year= 2002 | volume= 30 | issue= 6 | pages= 672-4 | pmid=12512867 | doi=10.1080/01926230290166760 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12512867 }} </ref><ref name="pmid2362779">{{cite journal| author=Burrell JH, Yong JL, Macdonald GJ| title=Experimental analgesic nephropathy: changes in renal structure and urinary concentrating ability in Fischer 344 rats given continuous low doses of aspirin and paracetamol. | journal=Pathology | year= 1990 | volume= 22 | issue= 1 | pages= 33-44 | pmid=2362779 | doi=10.3109/00313029009061423 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2362779 }} </ref> | ||
| Line 25: | Line 25: | ||
* Accumulation of sickle-shaped [[RBCs]] in patients with [[sickle cell disease]] can lead to [[intravascular]] [[obstruction]], blood [[stasis]] and [[thrombosis]] that results in [[ischemic necrosis]] of [[renal]] [[papillary]] and [[medullary]] cells.<ref name="pmid28341428">{{cite journal| author=Henderickx MMEL, Brits T, De Baets K, Seghers M, Maes P, Trouet D | display-authors=etal| title=Renal papillary necrosis in patients with sickle cell disease: How to recognize this 'forgotten' diagnosis. | journal=J Pediatr Urol | year= 2017 | volume= 13 | issue= 3 | pages= 250-256 | pmid=28341428 | doi=10.1016/j.jpurol.2017.01.020 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28341428 }} </ref> | * Accumulation of sickle-shaped [[RBCs]] in patients with [[sickle cell disease]] can lead to [[intravascular]] [[obstruction]], blood [[stasis]] and [[thrombosis]] that results in [[ischemic necrosis]] of [[renal]] [[papillary]] and [[medullary]] cells.<ref name="pmid28341428">{{cite journal| author=Henderickx MMEL, Brits T, De Baets K, Seghers M, Maes P, Trouet D | display-authors=etal| title=Renal papillary necrosis in patients with sickle cell disease: How to recognize this 'forgotten' diagnosis. | journal=J Pediatr Urol | year= 2017 | volume= 13 | issue= 3 | pages= 250-256 | pmid=28341428 | doi=10.1016/j.jpurol.2017.01.020 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28341428 }} </ref> | ||
==Gross Pathology== | |||
*The most important characteristics of [[renal papillary necrosis]] on gross pathology are irregular round shaped [[necrosis]] of [[renal]] [[papillary]] and [[medullary]] area. <ref name="urlRenal Papillary Necrosis - American Urological Association">{{cite web |url=https://www.auanet.org/education/auauniversity/education-products-and-resources/pathology-for-urologists/kidney/inflammatory/necrotic-renal-lesions/renal-papillary-necrosis#:~:text=Defined%20as%20necrosis%20of%20papillae,or%20as%20progressive%20renal%20failure. |title=Renal Papillary Necrosis - American Urological Association |format= |work= |accessdate=}}</ref> <ref name="pmid28584810">{{cite journal| author=Geller SA, de Campos FPF| title=Renal papillary necrosis. | journal=Autops Case Rep | year= 2013 | volume= 3 | issue= 4 | pages= 69-71 | pmid=28584810 | doi=10.4322/acr.2013.042 | pmc=5453664 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28584810 }} </ref> | |||
==Microscopic Pathology== | |||
*On microscopic histopathological analysis, the characteristic findings of [[renal papillary necrosis]] include<ref name="urlRenal Papillary Necrosis - American Urological Association">{{cite web |url=https://www.auanet.org/education/auauniversity/education-products-and-resources/pathology-for-urologists/kidney/inflammatory/necrotic-renal-lesions/renal-papillary-necrosis#:~:text=Defined%20as%20necrosis%20of%20papillae,or%20as%20progressive%20renal%20failure. |title=Renal Papillary Necrosis - American Urological Association |format= |work= |accessdate=}}</ref><ref name="urlRenal papillary necrosis | Radiology Reference Article | Radiopaedia.org">{{cite web |url=https://radiopaedia.org/articles/renal-papillary-necrosis?lang=us |title=Renal papillary necrosis | Radiology Reference Article | Radiopaedia.org |format= |work= |accessdate=}}</ref><ref name="pmid713272">{{cite journal| author=Lindvall N| title=Radiological changes of renal papillary necrosis. | journal=Kidney Int | year= 1978 | volume= 13 | issue= 1 | pages= 93-106 | pmid=713272 | doi=10.1038/ki.1978.12 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=713272 }} </ref>: | |||
**[[Coagulative necrosis]] of [[papillary]] area | |||
**swelling and sloughing of [[papilla]] | |||
**partial [[necrosis]] of [[medullary]] area | |||
**mild [[inflammation]] at [[necrotic]] area | |||
**[[microcalcifications]] at [[necrotic]] area | |||
*Other [[renal]] [[histological]] findings include<ref name="urlRenal Papillary Necrosis - American Urological Association">{{cite web |url=https://www.auanet.org/education/auauniversity/education-products-and-resources/pathology-for-urologists/kidney/inflammatory/necrotic-renal-lesions/renal-papillary-necrosis#:~:text=Defined%20as%20necrosis%20of%20papillae,or%20as%20progressive%20renal%20failure. |title=Renal Papillary Necrosis - American Urological Association |format= |work= |accessdate=}}</ref><ref name="pmid2194275">{{cite journal| author=Gregg NJ, Courtauld EA, Bach PH| title=High resolution light microscopic morphological and microvascular changes in an acutely induced renal papillary necrosis. | journal=Toxicol Pathol | year= 1990 | volume= 18 | issue= 1 Pt 1 | pages= 47-55 | pmid=2194275 | doi=10.1177/019262339001800107 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2194275 }} </ref>: | |||
**[[diabetic nephropathy]]: | |||
***diffuse nodular [[mesangial]] [[sclerosis]] | |||
**[[analgesic nephropathy]]: | |||
***[[interstitial]] [[fibrosis]] | |||
***[[cytoplasmic]] [[edema]] | |||
***dilation of [[organelles]] | |||
***increased production of [[proteoglycan]] | |||
***[[tubular]] [[atrophy]] | |||
***[[endothelial cell]] injury | |||
****[[capillary]] [[sclerosis]] | |||
***damage to [[loops of Henle]] | |||
***[[Platelet]] [[thrombus]] | |||
**[[sickle cell]] [[nephropathy]]: | |||
***[[intravascular]] [[obstruction]] | |||
***[[intravascular]] [[thrombosis]] | |||
| Line 32: | Line 58: | ||
[[Category:Kidney diseases]] | [[Category:Kidney diseases]] | ||
[[Category:Disease] | [[Category:Disease]] | ||
[[Category:Needs content]] | [[Category:Needs content]] | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Nasrin Nikravangolsefid, MD-MPH [2]
Overview
Renal papillary necrosis is a significant kidney disorder, which is associated with ischemia of the inner renal medulla and papilla due to chronic conditions such as diabetes, sickle cell disease, urinary tract obstruction, urinary tract infection and long term use of analgesics. Decreased prostaglandin synthesis and subsequent reduced renal blood flow is an important mechanism for developing renal papillary necrosis.
Pathogenesis
- The exact pathogenesis of renal papillary necrosis is not fully understood.
- It is thought that Renal papillary necrosis is the result of damage to interstitial medullary and papillary cells due to direct effect of diseases such as diabetes, sickle cell disease, urinary tract obstruction, renal vein thrombosis, upper urinary tract infection, tuberculosis, vasculitis, renal transplant rejection and long term analgesics use such as acetaminophen and NSAIDS. [1][2][3]
- Renal medullary and papillary cells are susceptible to ischemia. [5]
- Medullary cells usually produce prostaglandins and proteoglycans. [1]
- Damage of medullary cells leads to changes in renal matrix and vessels due to decreased production of prostaglandins that causes vasoconstriction, reduced renal perfusion, ischemia and necrosis. [1][6]
- Another mechanism is inhibiting cyclooxygenase enzymes; COX I and COX II, which play a major role in the prostaglandins synthesis, following NSAIDS use. [7]
- Multiple NSAIDS taking and hypovolemic condition could facilitate development of renal papillary necrosis. [1] [2]
- Accumulation of sickle-shaped RBCs in patients with sickle cell disease can lead to intravascular obstruction, blood stasis and thrombosis that results in ischemic necrosis of renal papillary and medullary cells.[8]
Gross Pathology
- The most important characteristics of renal papillary necrosis on gross pathology are irregular round shaped necrosis of renal papillary and medullary area. [9] [3]
Microscopic Pathology
- On microscopic histopathological analysis, the characteristic findings of renal papillary necrosis include[9][10][11]:
- Coagulative necrosis of papillary area
- swelling and sloughing of papilla
- partial necrosis of medullary area
- mild inflammation at necrotic area
- microcalcifications at necrotic area
- Other renal histological findings include[9][12]:
- diabetic nephropathy:
- analgesic nephropathy:
- interstitial fibrosis
- cytoplasmic edema
- dilation of organelles
- increased production of proteoglycan
- tubular atrophy
- endothelial cell injury
- damage to loops of Henle
- Platelet thrombus
- sickle cell nephropathy:
References
- ↑ 1.0 1.1 1.2 1.3 Brix AE (2002). "Renal papillary necrosis". Toxicol Pathol. 30 (6): 672–4. doi:10.1080/01926230290166760. PMID 12512867.
- ↑ 2.0 2.1 Sabatini S (1984). "Pathophysiology of drug-induced papillary necrosis". Fundam Appl Toxicol. 4 (6): 909–21. doi:10.1016/0272-0590(84)90229-x. PMID 6394414.
- ↑ 3.0 3.1 Geller SA, de Campos FPF (2013). "Renal papillary necrosis". Autops Case Rep. 3 (4): 69–71. doi:10.4322/acr.2013.042. PMC 5453664. PMID 28584810.
- ↑ By BruceBlaus. When using this image in external sources it can be cited as:Blausen.com staff (2014). "Medical gallery of Blausen Medical 2014". WikiJournal of Medicine 1 (2). DOI:10.15347/wjm/2014.010. ISSN 2002-4436. - Own work, CC BY 3.0, https://commons.wikimedia.org/w/index.php?curid=31118599
- ↑ Jung DC, Kim SH, Jung SI, Hwang SI, Kim SH (2006). "Renal papillary necrosis: review and comparison of findings at multi-detector row CT and intravenous urography". Radiographics. 26 (6): 1827–36. doi:10.1148/rg.266065039. PMID 17102053.
- ↑ Burrell JH, Yong JL, Macdonald GJ (1990). "Experimental analgesic nephropathy: changes in renal structure and urinary concentrating ability in Fischer 344 rats given continuous low doses of aspirin and paracetamol". Pathology. 22 (1): 33–44. doi:10.3109/00313029009061423. PMID 2362779.
- ↑ Brater DC, Harris C, Redfern JS, Gertz BJ (2001). "Renal effects of COX-2-selective inhibitors". Am J Nephrol. 21 (1): 1–15. doi:10.1159/000046212. PMID 11275626.
- ↑ Henderickx MMEL, Brits T, De Baets K, Seghers M, Maes P, Trouet D; et al. (2017). "Renal papillary necrosis in patients with sickle cell disease: How to recognize this 'forgotten' diagnosis". J Pediatr Urol. 13 (3): 250–256. doi:10.1016/j.jpurol.2017.01.020. PMID 28341428.
- ↑ 9.0 9.1 9.2 "Renal Papillary Necrosis - American Urological Association".
- ↑ "Renal papillary necrosis | Radiology Reference Article | Radiopaedia.org".
- ↑ Lindvall N (1978). "Radiological changes of renal papillary necrosis". Kidney Int. 13 (1): 93–106. doi:10.1038/ki.1978.12. PMID 713272.
- ↑ Gregg NJ, Courtauld EA, Bach PH (1990). "High resolution light microscopic morphological and microvascular changes in an acutely induced renal papillary necrosis". Toxicol Pathol. 18 (1 Pt 1): 47–55. doi:10.1177/019262339001800107. PMID 2194275.