Rapidly progressive glomerulonephritis laboratory findings: Difference between revisions

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{{Rapidly progressive glomerulonephritis}}
{{Rapidly progressive glomerulonephritis}}
{{CMG}}; {{AE}} {{MAD}}
{{CMG}}; {{AE}} {{MAD}}  {{N.F}}


==Overview==
==Overview==
The most important step in managing rapidly progressive glomerulonephritis is rapid diagnosis. It is essential for organ preservation. Laboratory studies include,
[[complete blood cell count]] (CBC) with differential, [[serum electrolytes]], BUN, [[creatinine]], [[lactate dehydrogenase]] (LDH), [[creatine phosphokinase]] (CPK), and [[liver function tests]]: The most common abnormality is an increased [[serum creatinine]] level. However, the level can be normal at presentation. Tissue enzyme (ie, LDH, CPK) levels may be elevated if there is significant muscle inflammation and [[myalgias]]. [[Urinalysis]] with microscopy usually show [[proteinuria]] but is rarely greater than 2-3 g in 24 hours. [[Microscopic hematuria]] may be  present and may be the only clue to renal disease at presentation. The presence of [[red cell casts]] indicates [[glomerulonephritis]] and is a very helpful clue. [[Erythrocyte sedimentation rate]] is usually elevated with active disease. [[C-reactive protein]] levels are elevated and correspond with disease activity. High [[antinuclear antibody]] (ANA) titer rises the suspicion toward [[systemic lupus erythematosus]]. More than 80% of patients with [[microscopic polyangiitis]] are [[Anti-neutrophil cytoplasmic antibody|ANCA]]-positive. The symptoms of [[cryoglobulinemia]] are very similar to those of [[Anti-neutrophil cytoplasmic antibody|ANCA]]-related disease. However, in persons with [[Anti-neutrophil cytoplasmic antibody|ANCA]]-related diseases, the cryoglobulin titer result should be negative. [[Hepatitis]] profile should be performed as hepatitis B is associated with [[polyarteritis nodosa]] and [[hepatitis C]] is associated with [[Cryoglobulinemia|mixed cryoglobulinemia.]] Urine and serum [[protein electrophoresis]] is done in any middle-aged or elderly person presenting with rapidly progressive glomerulonephritis to exclude the presence of light-chain disease or noticeable [[multiple myeloma]] as a cause of the clinical findings.


==Laboratory Findings==
==Laboratory Findings==
===Blood Work-Up===
===Blood Work-Up===
* [[Complete blood count]] (CBC)
* [[Complete blood count]] (CBC)
** Anemia
** Eosinophilia


* Serum [[Electrolyte|electrolytes]]
* Serum [[Electrolyte|electrolytes]]
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* Serum [[protein electrophoresis]]
* Serum [[protein electrophoresis]]


[[Anemia]] is common among patient with RPGN, mostly due to renally impaired production of [[erythropoietin]] or [[Gastrointestinal bleeding|GI bleeding]]. [[Eosinophilia]] may be seen in a subset of patients with [[Churg-Strauss syndrome|Churg-Strauss disease]].
'''Laboratory findings'''
 
* [[Anemia]] , mostly due to impaired production of [[erythropoietin]] by kidneys. or [[Gastrointestinal bleeding|GI bleeding]].
Patients with RPGN may show formation of [[immune complexes]] and [[cryoglobulins]]. [[Complement|Complement C3]] levels is usually low in immune-complex mediated RPGN. The presence of [[ANCA]] and [[Anti-GBM antibody|anti-GBM]] is variable; their presence is important for classification of disease and further management planning. Anti-GBM levels is However, anti-GBM antibody level is not prognostic and is not associated with disease activity.<ref name="pmid9744974">{{cite journal| author=Hricik DE, Chung-Park M, Sedor JR| title=Glomerulonephritis. | journal=N Engl J Med | year= 1998 | volume= 339 | issue= 13 | pages= 888-99 | pmid=9744974 | doi=10.1056/NEJM199809243391306 | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9744974 }} </ref>
* [[Eosinophilia]] is usually seen in patients with [[Churg-Strauss syndrome|Churg-Strauss disease]].
 
* Patients with RPGN may show formation of [[immune complexes]] and [[cryoglobulins]].  
On the contrary, literature regarding [[ANCA]]-associated [[glomerulonephritis]] suggests that levels of [[ANCA]] is associated with disease activity and may be used as an index for such purposes.<ref name="pmid2857806">{{cite journal| author=van der Woude FJ, Rasmussen N, Lobatto S, Wiik A, Permin H, van Es LA et al.| title=Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener's granulomatosis. | journal=Lancet | year= 1985 | volume= 1 | issue= 8426 | pages= 425-9 | pmid=2857806 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2857806 }} </ref><ref name="pmid2684074">{{cite journal| author=Tervaert JW, van der Woude FJ, Fauci AS, Ambrus JL, Velosa J, Keane WF et al.| title=Association between active Wegener's granulomatosis and anticytoplasmic antibodies. | journal=Arch Intern Med | year= 1989 | volume= 149 | issue= 11 | pages= 2461-5 | pmid=2684074 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2684074 }} </ref><ref name="pmid2221646">{{cite journal| author=Falk RJ, Hogan S, Carey TS, Jennette JC| title=Clinical course of anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis and systemic vasculitis. The Glomerular Disease Collaborative Network. | journal=Ann Intern Med | year= 1990 | volume= 113 | issue= 9 | pages= 656-63 | pmid=2221646 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2221646 }} </ref>
* [[Complement|Complement C3]] levels is usually low in immune-complex mediated RPGN.  
* The presence of [[ANCA]] and [[Anti-GBM antibody|anti-GBM]] is variable.
* [[ANCA]]-associated [[glomerulonephritis]] have high levels of [[ANCA]], it is associated with disease activity.<ref name="pmid2857806">{{cite journal| author=van der Woude FJ, Rasmussen N, Lobatto S, Wiik A, Permin H, van Es LA et al.| title=Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener's granulomatosis. | journal=Lancet | year= 1985 | volume= 1 | issue= 8426 | pages= 425-9 | pmid=2857806 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2857806 }} </ref><ref name="pmid2684074">{{cite journal| author=Tervaert JW, van der Woude FJ, Fauci AS, Ambrus JL, Velosa J, Keane WF et al.| title=Association between active Wegener's granulomatosis and anticytoplasmic antibodies. | journal=Arch Intern Med | year= 1989 | volume= 149 | issue= 11 | pages= 2461-5 | pmid=2684074 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2684074 }} </ref><ref name="pmid2221646">{{cite journal| author=Falk RJ, Hogan S, Carey TS, Jennette JC| title=Clinical course of anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis and systemic vasculitis. The Glomerular Disease Collaborative Network. | journal=Ann Intern Med | year= 1990 | volume= 113 | issue= 9 | pages= 656-63 | pmid=2221646 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2221646 }} </ref>


[[ESR]] and [[CRP]] may be elevated and are correlated with the level of inflammation and thus activity of the disease.
* [[ESR]] and [[CRP]] may be elevated and indicate inflammation and activity of the disease.


===Urine Work-Up===
===Urine Work-Up===

Latest revision as of 14:29, 31 July 2018

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohammed Abdelwahed M.D[2] Nazia Fuad M.D.

Overview

The most important step in managing rapidly progressive glomerulonephritis is rapid diagnosis. It is essential for organ preservation. Laboratory studies include, complete blood cell count (CBC) with differential, serum electrolytes, BUN, creatinine, lactate dehydrogenase (LDH), creatine phosphokinase (CPK), and liver function tests: The most common abnormality is an increased serum creatinine level. However, the level can be normal at presentation. Tissue enzyme (ie, LDH, CPK) levels may be elevated if there is significant muscle inflammation and myalgias. Urinalysis with microscopy usually show proteinuria but is rarely greater than 2-3 g in 24 hours. Microscopic hematuria may be present and may be the only clue to renal disease at presentation. The presence of red cell casts indicates glomerulonephritis and is a very helpful clue. Erythrocyte sedimentation rate is usually elevated with active disease. C-reactive protein levels are elevated and correspond with disease activity. High antinuclear antibody (ANA) titer rises the suspicion toward systemic lupus erythematosus. More than 80% of patients with microscopic polyangiitis are ANCA-positive. The symptoms of cryoglobulinemia are very similar to those of ANCA-related disease. However, in persons with ANCA-related diseases, the cryoglobulin titer result should be negative. Hepatitis profile should be performed as hepatitis B is associated with polyarteritis nodosa and hepatitis C is associated with mixed cryoglobulinemia. Urine and serum protein electrophoresis is done in any middle-aged or elderly person presenting with rapidly progressive glomerulonephritis to exclude the presence of light-chain disease or noticeable multiple myeloma as a cause of the clinical findings.

Laboratory Findings

Blood Work-Up

Laboratory findings

  • ESR and CRP may be elevated and indicate inflammation and activity of the disease.

Urine Work-Up

References

  1. van der Woude FJ, Rasmussen N, Lobatto S, Wiik A, Permin H, van Es LA; et al. (1985). "Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener's granulomatosis". Lancet. 1 (8426): 425–9. PMID 2857806.
  2. Tervaert JW, van der Woude FJ, Fauci AS, Ambrus JL, Velosa J, Keane WF; et al. (1989). "Association between active Wegener's granulomatosis and anticytoplasmic antibodies". Arch Intern Med. 149 (11): 2461–5. PMID 2684074.
  3. Falk RJ, Hogan S, Carey TS, Jennette JC (1990). "Clinical course of anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis and systemic vasculitis. The Glomerular Disease Collaborative Network". Ann Intern Med. 113 (9): 656–63. PMID 2221646.
  4. Hricik DE, Chung-Park M, Sedor JR (1998). "Glomerulonephritis". N Engl J Med. 339 (13): 888–99. doi:10.1056/NEJM199809243391306. PMID 9744974.

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