Rapidly progressive glomerulonephritis risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Jogeet Singh Sekhon, M.D. [2]

Overview

Common risk factors in the development of rapidly progressive glomerulonephritis may be occupational, environmental, genetic, and viral.

Risk Factors

Common risk factors in the development of rapidly progressive glomerulonephritis may be occupational, environmental, genetic, and viral. [1][2]

Common risk factrors

  • Presence of HLADRB1, HLA DP1, DQ and DRB4s[3]

Less common risk factors

  • Cocaine use
  • Exposure to hydrocarbons( formaldehyde)
  • HIgh concenteration of FiO2

References

  1. Hellmark T, Segelmark M (2014). "Diagnosis and classification of Goodpasture's disease (anti-GBM)". J Autoimmun. 48-49: 108–12. doi:10.1016/j.jaut.2014.01.024. PMID 24456936.
  2. Bombassei GJ, Kaplan AA (1992). "The association between hydrocarbon exposure and anti-glomerular basement membrane antibody-mediated disease (Goodpasture's syndrome)". Am J Ind Med. 21 (2): 141–53. PMID 1536151.
  3. Jagiello P, Gross WL, Epplen JT (2005). "Complex genetics of Wegener granulomatosis". Autoimmun Rev. 4 (1): 42–7. doi:10.1016/j.autrev.2004.06.003. PMID 15652778.

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