Pulmonary embolism historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editors-in-Chief: Ujjwal Rastogi, MBBS [2]

Overview

Insights into the historical perspective of PE is useful in deciding contemporary advances. Throughout history many renowned researchers and health care professionals have contributed to the understanding, definition, and treatment of pulmonary embolism. The first written reference to thrombotic disease is probably found in the ancient Indian medical texts of Ayurveda physician and surgeon, Sushruta (circa 600–1000 BCE), which describes a patient who had a ‘‘swollen and painful leg which was difficult to treat.’’[1]

Year Event
1837 First case report on Pulmonary embolism.
1922 Description of signs at chest xray.
Prior to 1930 Viewed almost universally fatal, with surgery the only treatment(despite an operative mortality of 100%).
1935 Heparin discovered in 1916 but in this year it entered into clinical trial.
1940 Hampton and Castleman described the radiographic appearance of pulmonary embolism and pulmonary infarction.
1977 Physician Eugene Robin[2] published a landmark article stating the use of Pulmonary angiography as an approach to diagnosing PE.
1992 Spiral CT was used in the diagnosis.

References

  1. Wood KE (2009). "A history of pulmonary embolism and deep venous thrombosis". Crit Care Clin. 25 (1): 115–31, viii. doi:10.1016/j.ccc.2008.12.014. PMID 19268798.
  2. Robin ED (1977). "Overdiagnosis and overtreatment of pulmonary embolism: the emperor may have no clothes". Ann Intern Med. 87 (6): 775–81. PMID 931212.

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