Polycythemia vera history and symptoms: Difference between revisions

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__NOTOC__
__NOTOC__
{{Polycythemia vera}}
{{Polycythemia vera}}
{{CMG}} {{AE}} {{MJK}}; {{shyam}}
{{CMG}} {{AE}} {{IO}} {{MJK}}; {{shyam}}
==Overview==
==Overview==
People with polycythemia vera usually asymptomatic. Symptoms of polycythemia vera include [[headache]], [[fatigue]], and [[pruritis]]. The symptomatology is highly variable between patients. Some patients can present with a minimal symptom burden that does not result in any change in quality of life, and other patients can have severe symptom burden.
People with polycythemia vera usually asymptomatic. Symptoms of polycythemia vera include [[headache]], [[fatigue]], and [[pruritis]] especially after exposure to warm water, loss of concentration and [[night sweats]] and neurological symptoms.  
 
==History and Symptoms==  
==History and Symptoms==
===History===
Symptoms of polycythemia vera are related to the consequences of excess [[red blood cells]]. These symptoms may include:
Patients with polycythemia vera may have a positive history of:<ref name="Tefferi2002">{{cite journal|last1=Tefferi|first1=A.|title=Selective serotonin reuptake inhibitors are effective in the treatment of polycythemia vera-associated pruritus|journal=Blood|volume=99|issue=7|year=2002|pages=2627–2627|issn=00064971|doi=10.1182/blood.V99.7.2627}}</ref>
*[[Pruritus]]
*[[Fatigue]]
*[[Headache]]
*[[Headache]]
*[[Pruritis]]
*[[Early satiety]]
:*Especially after exposure to warm water
:*Due to [[histamine]] release or [[prostaglandin]] production
:*Present in approximately 40% of patients
*[[Tinnitis]]
*[[Blurred vision]]
*[[Malaise]]
*[[Loss of appetite]]
*[[Weight loss]]
*[[Shortness of breath]]
*[[Fatigue]]
*[[Dizziness]]
*[[Bleeding]]
:*[[Bruising]]
:*[[Epistaxis]]
:*[[Bleeding gums]]
:*[[Menorrhagia]]
:*[[Metrorrhagia]]
:*[[Petechiae]]
*[[Chest pain]]
*[[Arthralgia]]
*[[Erythromelalgia]]
*[[Heart burn]]
:* Due to increased susceptibility to infection with [[Helicobacter pylori|H. pylori]]
 
==History and Symptoms==
*The majority of patients with [disease name] are asymptomatic.
OR
*The hallmark of [disease name] is [finding]. A positive history of [finding 1] and [finding 2] is suggestive of [disease name]. The most common symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
*Symptoms of [disease name] include [symptom 1], [symptom 2], and [symptom 3].
===History===
Patients with [disease name]] may have a positive history of:
*[History finding 1]
*[History finding 2]
*[History finding 3]


===Common Symptoms===
===Common Symptoms===
Common symptoms of polycythemia vera include:{{cite journal |vauthors=Stein BL, Oh ST, Berenzon D, Hobbs GS, Kremyanskaya M, Rampal RK, Abboud CN, Adler K, Heaney ML, Jabbour EJ, Komrokji RS, Moliterno AR, Ritchie EK, Rice L, Mascarenhas J, Hoffman R |title=Polycythemia Vera: An Appraisal of the Biology and Management 10 Years After the Discovery of JAK2 V617F |journal=J. Clin. Oncol. |volume=33 |issue=33 |pages=3953–60 |date=November 2015 |pmid=26324368 |pmc=4979103 |doi=10.1200/JCO.2015.61.6474 |url=}}
Common symptoms of polycythemia vera include:<ref name="Tefferi2002">{{cite journal|last1=Tefferi|first1=A.|title=Selective serotonin reuptake inhibitors are effective in the treatment of polycythemia vera-associated pruritus|journal=Blood|volume=99|issue=7|year=2002|pages=2627–2627|issn=00064971|doi=10.1182/blood.V99.7.2627}}</ref><ref name="pmid19468728">{{cite journal |vauthors=Cario H, McMullin MF, Pahl HL |title=Clinical and hematological presentation of children and adolescents with polycythemia vera |journal=Ann. Hematol. |volume=88 |issue=8 |pages=713–9 |date=August 2009 |pmid=19468728 |pmc=4135082 |doi=10.1007/s00277-009-0758-y |url=}}</ref><ref name="pmid20597963">{{cite journal |vauthors=Saini KS, Patnaik MM, Tefferi A |title=Polycythemia vera-associated pruritus and its management |journal=Eur. J. Clin. Invest. |volume=40 |issue=9 |pages=828–34 |date=September 2010 |pmid=20597963 |doi=10.1111/j.1365-2362.2010.02334.x |url=}}</ref>
*Fatigue
*[[Fatigue]]
*Headache
*[[Headache]]
*[[Pruritus]]
**Especially after exposure to warm water
**May be related to [[serotonin]] release by [[Platelet|platelets]] as well as elevated [[histamine]] levels
*Abdominal pain
*Abdominal pain
*Loss of concentration
*Loss of concentration
*Night sweats  
*[[Night sweats]]
*Sexual problems
*Sexual problems
*Insomnia
*[[Insomnia]]
*Decreased mood
*Decreased mood
*Numbness
*[[Numbness]]
*Early satiety  
*[[Early satiety]]
*Dizziness  
*[[Dizziness]]
*Cough  
*[[Cough]]
*Bone pains
*[[Erythromelalgia]]
*[[Weakness]]


===Less Common Symptoms===
===Less Common Symptoms===
Less common symptoms of polycythemia vera include  
Less common symptoms of polycythemia vera include:<ref name="pmid26324368">{{cite journal |vauthors=Stein BL, Oh ST, Berenzon D, Hobbs GS, Kremyanskaya M, Rampal RK, Abboud CN, Adler K, Heaney ML, Jabbour EJ, Komrokji RS, Moliterno AR, Ritchie EK, Rice L, Mascarenhas J, Hoffman R |title=Polycythemia Vera: An Appraisal of the Biology and Management 10 Years After the Discovery of JAK2 V617F |journal=J. Clin. Oncol. |volume=33 |issue=33 |pages=3953–60 |date=November 2015 |pmid=26324368 |pmc=4979103 |doi=10.1200/JCO.2015.61.6474 |url=}}</ref>
*Fever
*[[Fever]]
*Weight loss
*Weight loss
*Sweating
*Visual disturbances
*[[Parasthesias|Paresthesia]]
*[[Dyspnea]]
*Bone pains


==References==
==References==
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{{Hematology}}
{{Hematology}}
{{Hematological malignancy histology}}
{{Hematological malignancy histology}}


[[Category:Disease]]
[[Category:Disease]]

Latest revision as of 03:06, 14 September 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Ifeoma Odukwe, M.D. [2] Mohamad Alkateb, MBBCh [3]; Shyam Patel [4]

Overview

People with polycythemia vera usually asymptomatic. Symptoms of polycythemia vera include headache, fatigue, and pruritis especially after exposure to warm water, loss of concentration and night sweats and neurological symptoms.

History and Symptoms

History

Patients with polycythemia vera may have a positive history of:[1]

Common Symptoms

Common symptoms of polycythemia vera include:[1][2][3]

Less Common Symptoms

Less common symptoms of polycythemia vera include:[4]

References

  1. 1.0 1.1 Tefferi, A. (2002). "Selective serotonin reuptake inhibitors are effective in the treatment of polycythemia vera-associated pruritus". Blood. 99 (7): 2627–2627. doi:10.1182/blood.V99.7.2627. ISSN 0006-4971.
  2. Cario H, McMullin MF, Pahl HL (August 2009). "Clinical and hematological presentation of children and adolescents with polycythemia vera". Ann. Hematol. 88 (8): 713–9. doi:10.1007/s00277-009-0758-y. PMC 4135082. PMID 19468728.
  3. Saini KS, Patnaik MM, Tefferi A (September 2010). "Polycythemia vera-associated pruritus and its management". Eur. J. Clin. Invest. 40 (9): 828–34. doi:10.1111/j.1365-2362.2010.02334.x. PMID 20597963.
  4. Stein BL, Oh ST, Berenzon D, Hobbs GS, Kremyanskaya M, Rampal RK, Abboud CN, Adler K, Heaney ML, Jabbour EJ, Komrokji RS, Moliterno AR, Ritchie EK, Rice L, Mascarenhas J, Hoffman R (November 2015). "Polycythemia Vera: An Appraisal of the Biology and Management 10 Years After the Discovery of JAK2 V617F". J. Clin. Oncol. 33 (33): 3953–60. doi:10.1200/JCO.2015.61.6474. PMC 4979103. PMID 26324368.

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