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{{Plummer-Vinson syndrome}}
{{Plummer-Vinson syndrome}}
{{CMG}};{{AE}}
{{CMG}};{{AE}}{{Akshun}}


==Overview==
==Overview==
If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
If left untreated, patients of Plummer-Vinson syndrome may progress to develop [[fatigue]], [[dyspnea on exertion]], [[Esophageal stricture|esophageal strictures]], and [[malignant]] lesions of the [[mouth]] and [[oral cavity]]. Common complications of Plummer-Vinson syndrome include [[hypopharyngeal cancer]], [[esophageal cancer]] and [[malignant]] lesions of [[oral mucosa]]. Depending on the extent of Plummer-Vinson syndrome at the time of [[diagnosis]], the [[prognosis]] may vary. [[Prognosis]] is generally good for patients who receive treatment. [[Iron]] replacement therapy and [[dilatation]] of [[Esophageal webs|esophageal web]] leads to rapid reversal of [[symptoms]].


OR
Common complications of [disease name] include [complication 1], [complication 2], and [complication 3].
OR
Prognosis is generally excellent/good/poor, and the 1/5/10-year mortality/survival rate of patients with [disease name] is approximately [#]%.
==Natural History, Complications, and Prognosis==
==Natural History, Complications, and Prognosis==
===Natural History===
===Natural History===
*The symptoms of (disease name) usually develop in the first/ second/ third decade of life, and start with symptoms such as ___.  
*The symptoms of Plummer-Vinson syndrome usually develop in the fourth decade of life, and start with symptoms such as [[fatigue]], [[Tongue swelling|swollen tongue]] and [[Dysphagia|pain while swallowing]].
*The symptoms of (disease name) typically develop ___ years after exposure to ___.  
*If left untreated, patients of Plummer-Vinson syndrome may progress to develop [[dysphagia]], [[Esophageal stricture|esophageal strictures]], [[Pharyngeal cancer (patient information)|pharyngeal]] and [[esophageal cancer]].
*If left untreated, [#]% of patients with [disease name] may progress to develop [manifestation 1], [manifestation 2], and [manifestation 3].
** Initially patients of Plummer-Vinson syndrome presents with [[dysphagia]] for solid food.
** As the disease progresses, [[esophageal webs]] and [[strictures]] become more apparent and progress to present with [[dysphagia]] for solid, choking spells and [[aspiration]].
** Untreated Plummer-Vinson syndrome has the potential to transform into [[Hypopharyngeal cancer|hypopharyngeal]] and [[esophageal carcinoma]] ([[squamous cell carcinoma]]).


===Complications===
===Complications===
*Common complications of Plummer-Vinson syndrome include:<ref name="pmid1192404">{{cite journal |vauthors=Larsson LG, Sandström A, Westling P |title=Relationship of Plummer-Vinson disease to cancer of the upper alimentary tract in Sweden |journal=Cancer Res. |volume=35 |issue=11 Pt. 2 |pages=3308–16 |year=1975 |pmid=1192404 |doi= |url=}}</ref><ref name="pmid10406289">{{cite journal |vauthors=Rashid Z, Kumar A, Komar M |title=Plummer-Vinson syndrome and postcricoid carcinoma: late complications of unrecognized celiac disease |journal=Am. J. Gastroenterol. |volume=94 |issue=7 |pages=1991 |year=1999 |pmid=10406289 |doi=10.1111/j.1572-0241.1999.01991.x |url=}}</ref>
*Common complications of Plummer-Vinson syndrome include:<ref name="pmid1192404">{{cite journal |vauthors=Larsson LG, Sandström A, Westling P |title=Relationship of Plummer-Vinson disease to cancer of the upper alimentary tract in Sweden |journal=Cancer Res. |volume=35 |issue=11 Pt. 2 |pages=3308–16 |year=1975 |pmid=1192404 |doi= |url=}}</ref><ref name="pmid10406289">{{cite journal |vauthors=Rashid Z, Kumar A, Komar M |title=Plummer-Vinson syndrome and postcricoid carcinoma: late complications of unrecognized celiac disease |journal=Am. J. Gastroenterol. |volume=94 |issue=7 |pages=1991 |year=1999 |pmid=10406289 |doi=10.1111/j.1572-0241.1999.01991.x |url=}}</ref>
**Hypopharyngeal cancer
**[[Hypopharyngeal cancer]]
**Esophageal cancer
**[[Esophageal cancer]]
**Malignant lesions of oral mucosa
**[[Malignant]] lesions of [[oral mucosa]]
**High-output heart failure
**[[Heart failure preserved ejection fraction|High-output heart failure]]
**Preterm delivery  
**[[Preterm birth|Preterm delivery]]
**Developmental delay
**[[Developmental delay]]


===Prognosis===
===Prognosis===
* Depending on the extent of Plummer-Vinson syndrome at the time of diagnosis, the prognosis may vary.<ref name="pmid25028578">{{cite journal |vauthors=Tahara T, Shibata T, Okubo M, Yoshioka D, Ishizuka T, Sumi K, Kawamura T, Nagasaka M, Nakagawa Y, Nakamura M, Arisawa T, Ohmiya N, Hirata I |title=A case of plummer-vinson syndrome showing rapid improvement of Dysphagia and esophageal web after two weeks of iron therapy |journal=Case Rep Gastroenterol |volume=8 |issue=2 |pages=211–5 |year=2014 |pmid=25028578 |pmc=4086037 |doi=10.1159/000364820 |url=}}</ref><ref name="pmid25878483">{{cite journal |vauthors=Samad A, Mohan N, Balaji RV, Augustine D, Patil SG |title=Oral manifestations of plummer-vinson syndrome: a classic report with literature review |journal=J Int Oral Health |volume=7 |issue=3 |pages=68–71 |year=2015 |pmid=25878483 |pmc=4385731 |doi= |url=}}</ref><ref name="pmid12809857">{{cite journal |vauthors=Jessner W, Vogelsang H, Püspök A, Ferenci P, Gangl A, Novacek G, Bodisch A, Wenzl E |title=Plummer-Vinson syndrome associated with celiac disease and complicated by postcricoid carcinoma and carcinoma of the tongue |journal=Am. J. Gastroenterol. |volume=98 |issue=5 |pages=1208–9 |year=2003 |pmid=12809857 |doi=10.1111/j.1572-0241.2003.07438.x |url=}}</ref>
* Depending on the extent of Plummer-Vinson syndrome at the time of [[diagnosis]], the [[prognosis]] may vary.<ref name="pmid25028578">{{cite journal |vauthors=Tahara T, Shibata T, Okubo M, Yoshioka D, Ishizuka T, Sumi K, Kawamura T, Nagasaka M, Nakagawa Y, Nakamura M, Arisawa T, Ohmiya N, Hirata I |title=A case of plummer-vinson syndrome showing rapid improvement of Dysphagia and esophageal web after two weeks of iron therapy |journal=Case Rep Gastroenterol |volume=8 |issue=2 |pages=211–5 |year=2014 |pmid=25028578 |pmc=4086037 |doi=10.1159/000364820 |url=}}</ref><ref name="pmid25878483">{{cite journal |vauthors=Samad A, Mohan N, Balaji RV, Augustine D, Patil SG |title=Oral manifestations of plummer-vinson syndrome: a classic report with literature review |journal=J Int Oral Health |volume=7 |issue=3 |pages=68–71 |year=2015 |pmid=25878483 |pmc=4385731 |doi= |url=}}</ref><ref name="pmid12809857">{{cite journal |vauthors=Jessner W, Vogelsang H, Püspök A, Ferenci P, Gangl A, Novacek G, Bodisch A, Wenzl E |title=Plummer-Vinson syndrome associated with celiac disease and complicated by postcricoid carcinoma and carcinoma of the tongue |journal=Am. J. Gastroenterol. |volume=98 |issue=5 |pages=1208–9 |year=2003 |pmid=12809857 |doi=10.1111/j.1572-0241.2003.07438.x |url=}}</ref>
* Prognosis is generally good for patients of Plummer-Vinson syndrome who receive treatment unless complicated by pharyngeal or esophageal carcinoma.
** [[Prognosis]] is generally good for patients of Plummer-Vinson syndrome who receive treatment unless the disease has been complicated by [[Pharyngeal cancer (patient information)|pharyngeal]] or [[esophageal carcinoma]].
* Anemia and esophageal webs seen in Plummer-Vinson syndrome can be rapidly reversed with iron replacement therapy and dilatation respectively.
** [[Anemia]] and [[esophageal webs]] seen in Plummer-Vinson syndrome can be rapidly reversed with [[Iron(II) acetate|iron]] replacement therapy and esophageal [[dilatation]] respectively.
* Studies have shown that patients of Plummer-Vinson syndrome are at a high risk of developing malignant lesions of the oral mucosa, hypopharynx, and esophagus. Therefore, untreated patients require regular surveillance and close follow up.
** Studies have shown that patients of Plummer-Vinson syndrome are at a risk (10-15%) of developing [[malignant]] lesions of the [[oral mucosa]], [[hypopharynx]] and [[esophagus]]. Therefore, patients require regular surveillance (upper [[gastrointestinal]] [[endoscopy]] is recommended every year) and close follow up.<ref name="pmid7575056">{{cite journal |vauthors=Hoffman RM, Jaffe PE |title=Plummer-Vinson syndrome. A case report and literature review |journal=Arch. Intern. Med. |volume=155 |issue=18 |pages=2008–11 |year=1995 |pmid=7575056 |doi= |url=}}</ref>


==References==
==References==

Latest revision as of 18:13, 24 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Akshun Kalia M.B.B.S.[2]

Overview

If left untreated, patients of Plummer-Vinson syndrome may progress to develop fatigue, dyspnea on exertion, esophageal strictures, and malignant lesions of the mouth and oral cavity. Common complications of Plummer-Vinson syndrome include hypopharyngeal cancer, esophageal cancer and malignant lesions of oral mucosa. Depending on the extent of Plummer-Vinson syndrome at the time of diagnosis, the prognosis may vary. Prognosis is generally good for patients who receive treatment. Iron replacement therapy and dilatation of esophageal web leads to rapid reversal of symptoms.

Natural History, Complications, and Prognosis

Natural History

Complications

Prognosis

References

  1. ↑ Larsson LG, Sandström A, Westling P (1975). "Relationship of Plummer-Vinson disease to cancer of the upper alimentary tract in Sweden". Cancer Res. 35 (11 Pt. 2): 3308–16. PMID 1192404.
  2. ↑ Rashid Z, Kumar A, Komar M (1999). "Plummer-Vinson syndrome and postcricoid carcinoma: late complications of unrecognized celiac disease". Am. J. Gastroenterol. 94 (7): 1991. doi:10.1111/j.1572-0241.1999.01991.x. PMID 10406289.
  3. ↑ Tahara T, Shibata T, Okubo M, Yoshioka D, Ishizuka T, Sumi K, Kawamura T, Nagasaka M, Nakagawa Y, Nakamura M, Arisawa T, Ohmiya N, Hirata I (2014). "A case of plummer-vinson syndrome showing rapid improvement of Dysphagia and esophageal web after two weeks of iron therapy". Case Rep Gastroenterol. 8 (2): 211–5. doi:10.1159/000364820. PMC 4086037. PMID 25028578.
  4. ↑ Samad A, Mohan N, Balaji RV, Augustine D, Patil SG (2015). "Oral manifestations of plummer-vinson syndrome: a classic report with literature review". J Int Oral Health. 7 (3): 68–71. PMC 4385731. PMID 25878483.
  5. ↑ Jessner W, Vogelsang H, Püspök A, Ferenci P, Gangl A, Novacek G, Bodisch A, Wenzl E (2003). "Plummer-Vinson syndrome associated with celiac disease and complicated by postcricoid carcinoma and carcinoma of the tongue". Am. J. Gastroenterol. 98 (5): 1208–9. doi:10.1111/j.1572-0241.2003.07438.x. PMID 12809857.
  6. ↑ Hoffman RM, Jaffe PE (1995). "Plummer-Vinson syndrome. A case report and literature review". Arch. Intern. Med. 155 (18): 2008–11. PMID 7575056.

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