Plummer-Vinson syndrome historical perspective

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

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Overview

Historical Perspective

Discovery

The historical perspective associated with Plummer-Vinson syndrome is as below:[1][2]

  • In 1543: Vesalius describes the anatomy of the esophagus.
  • In 1592: Fabricius Aquapendente employs wax tampers to remove foreign bodies from the esophagus.
  • In 1674: T. Willis uses whale bone to dilate the esophagus.
  • In 1764: Ludlow describes a pharyngoesophageal diverticulum.
  • In 1806: Bozzini develops an early endoscope using a mirror and reflected light from a candle in an attempt to see the upper esophagus.
  • In 1843: Switzer invents the esophageal dilators.
  • In 1844: The first recorded operation of esophagotomy for the relief of esophageal stricture by John Watson an American surgeon.
  • In 1872: First excision of the esophagus in man, performed by Christian Albert Theodor Billroth, an Austrian surgeon.
  • In 1883: Esophageal motility in human beings is determined by H. Kronecker and S. Meltzer with pressure measurements of inserted balloons.
  • In 1954: L.R. Celestin develops an esophageal tube widely used for the relief of malignant dysphagia.
  • In 1982: D. Fleischer employs endoscopic laser therapy to palliate cases of esophageal carcinoma.


  • In the year 1912, Henry Plummer an American internist, was the first to describe Plummer-Vinson syndrome in a case series of patients with long-standing iron deficiency anemia, dysphagia and spasm of the upper esophagus without anatomic stenosis in his article "Diffuse dilatation of the esophagus without anatomic stenosis"
  • In the year 1919, Porter Paisley Vinson an American surgeon at the Mayo Clinic further described Plummer-Vinson syndrome in his article "A case of cardiospasm with dilatation and angulation of the esophagus." He reported a case of angulation of esophagus and attributed his findings to be consistent with the those described by Henry Plummer.

1913: Torek, using a transthoracic approach, is the first to successfully resect an esophageal carcinoma.


  • In the year 1919, Donald Ross Paterson and Adam Brown Kelly, both British otolaryngologist described the characteristic clinical features of Plummer-Vinson syndrome in their article "A clinical type of dysphagia" and "Spasm at the entrance of the esophagus" respectively.



  • The association between [important risk factor/cause] and [disease name] was made in/during [year/event].
  • In [year], [scientist] was the first to discover the association between [risk factor] and the development of [disease name].
  • In [year], [gene] mutations were first implicated in the pathogenesis of [disease name].

Outbreaks

  • There have been several outbreaks of [disease name], which are summarized below:

Landmark Events in the Development of Treatment Strategies

  • In [year], [diagnostic test/therapy] was developed by [scientist] to treat/diagnose [disease name].

Impact on Cultural History

Famous Cases

References

  1. Ormerod FC (1966). "Plummer-Vinson or Paterson-Brown Kelly. Priority, precedence or prestige?". J Laryngol Otol. 80 (9): 894–901. PMID 5332006.
  2. Lippi L (1966). "[The syndrome of Plummer-Vinson, of Brown Kelly-Paterson, or of Paterson-Vinson?]". Boll Mal Orecch Gola Naso (in Italian). 84 (1): 45–52. PMID 5942643.

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