POEMS syndrome causes: Difference between revisions

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{{CMG}}; {{AE}}{{Sab}}
{{CMG}}; {{AE}}{{Sab}}
==Overview==
==Overview==
There are no known and well established causes of POEMS syndrome. Marked activation of the pro-inflammatory cytokines and weak or decreased TGF beta 1 action can play a role in the disease pathogenesis.
There are no known and well established causes of POEMS [[syndrome]]. Marked activation of the [[Inflammation|pro-inflammatory]] [[Cytokine|cytokines]] and weak or decreased [[TGF beta 1]] action can play a role in the disease [[pathogenesis]].
==Causes==
==Causes==
*There are no known and well established causes of POEMS syndrome.
*There are no known and well established causes of POEMS [[syndrome]].
*Some studies suggest that marked activation of the pro-inflammatory cytokines (IL-1 beta, IL-6, and TNF-alpha) play a role in the disease pathogenesis.<ref name="pmid8608236">{{cite journal |vauthors=Gherardi RK, Bélec L, Soubrier M, Malapert D, Zuber M, Viard JP, Intrator L, Degos JD, Authier FJ |title=Overproduction of proinflammatory cytokines imbalanced by their antagonists in POEMS syndrome |journal=Blood |volume=87 |issue=4 |pages=1458–65 |date=February 1996 |pmid=8608236 |doi= |url=}}</ref>  
*Some studies suggest that marked activation of the [[Inflamation|pro-inflammatory]] [[cytokines]] ([[IL-1]] beta, [[Interleukin 6|IL-6]], and [[Tumor necrosis factor-alpha|TNF-alpha]]) play a role in the disease [[pathogenesis]].<ref name="pmid8608236">{{cite journal |vauthors=Gherardi RK, Bélec L, Soubrier M, Malapert D, Zuber M, Viard JP, Intrator L, Degos JD, Authier FJ |title=Overproduction of proinflammatory cytokines imbalanced by their antagonists in POEMS syndrome |journal=Blood |volume=87 |issue=4 |pages=1458–65 |date=February 1996 |pmid=8608236 |doi= |url=}}</ref>  
*Weak or even decreased (TGF beta 1) antagonistic reaction insufficient to counteract the noxious effects of cytokines can also result in this syndrome.<ref name="pmid8608236">{{cite journal |vauthors=Gherardi RK, Bélec L, Soubrier M, Malapert D, Zuber M, Viard JP, Intrator L, Degos JD, Authier FJ |title=Overproduction of proinflammatory cytokines imbalanced by their antagonists in POEMS syndrome |journal=Blood |volume=87 |issue=4 |pages=1458–65 |date=February 1996 |pmid=8608236 |doi= |url=}}</ref>
*Weak or even decreased [[TGF beta 1|(TGF beta 1)]] [[Antagonist|antagonistic]] [[reaction]] insufficient to counteract the [[Poison|noxious]] effects of [[Cytokine|cytokines]] can also result in this [[syndrome]].<ref name="pmid8608236">{{cite journal |vauthors=Gherardi RK, Bélec L, Soubrier M, Malapert D, Zuber M, Viard JP, Intrator L, Degos JD, Authier FJ |title=Overproduction of proinflammatory cytokines imbalanced by their antagonists in POEMS syndrome |journal=Blood |volume=87 |issue=4 |pages=1458–65 |date=February 1996 |pmid=8608236 |doi= |url=}}</ref>


==References==
==References==

Latest revision as of 01:50, 4 February 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sabawoon Mirwais, M.B.B.S, M.D.[2]

Overview

There are no known and well established causes of POEMS syndrome. Marked activation of the pro-inflammatory cytokines and weak or decreased TGF beta 1 action can play a role in the disease pathogenesis.

Causes

References

  1. 1.0 1.1 Gherardi RK, Bélec L, Soubrier M, Malapert D, Zuber M, Viard JP, Intrator L, Degos JD, Authier FJ (February 1996). "Overproduction of proinflammatory cytokines imbalanced by their antagonists in POEMS syndrome". Blood. 87 (4): 1458–65. PMID 8608236.

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