Optic nerve glioma history and symptoms: Difference between revisions

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==Overview==
==Overview==
Symptoms of optic nerve glioma include [[proptosis]], unilaterl or bilateral visual impairment, involuntary eyeball movement, squinting, [[obstructive hydrocephalus]] and [[diencephalic syndrome]].
Symptoms of optic nerve glioma include [[proptosis]], unilateral or bilateral [[visual impairment]], involuntary eyeball movement, squinting, [[vomiting]], irritability, poor feeding , [[seizures]], deficits in muscle tone and strength, daytime [[sleepiness]], decreased [[memory]] and [[brain]] function, [[weight loss]], delayed growth and [[loss of appetite]].
 
==History==
==History==
Most frequently optic pathway glioma patients present in the first decade with a median age of 8.8 years. They present with slowly progressive visual loss which is followed later by proptosis. Acute visual loss due to hemorrhage into the tumor is rare.
 
==Common Symptoms==
==Common Symptoms==
Decreased vision (63%) is usually evident and can be documented with visual field examination if the child is old enough. Eventually mass effects will also occur, with proptosis and even intracranial sequelae including symptoms of raised intracranial pressure, focal neurological deficits and [[hydrocephalus]] from distortion of the midbrain. Involvement of the hypothalamus may result in [[polyuria]] or [[polydipsia]].<ref name="radio">  Optic nerve glioma. Radiopedia(2015) http://radiopaedia.org/articles/optic-nerve-glioma Accessed on October 5 2015</ref>  
Decreased vision (63%) is usually evident and can be documented with visual field examination if the child is old enough. Eventually mass effects will also occur, with [[proptosis]] and even intracranial sequelae including symptoms of raised [[intracranial pressure]], focal neurological deficits and [[hydrocephalus]] from distortion of the midbrain. Involvement of the [[hypothalamus]] may result in [[polyuria]] or [[polydipsia]].<ref name="radio">  Optic nerve glioma. Radiopedia(2015) http://radiopaedia.org/articles/optic-nerve-glioma Accessed on October 5 2015</ref>  


The symptoms of optic pathway gliomas usually develop over a period of months to years and usually depend upon the location of the tumor.
Common symptoms of optic pathway gliomas include:
*[[Proptosis]]- It is the presenting symptom.
*[[Proptosis]]
*Impaired vision- In patients with chiasmal lesions, it is the presenting symptom.
*Unilateral or bilateral [[visual impairment]].
*[[Obstructive hydrocephalus]] may also be noted as presenting symptom.
*Optic nerve gliomas may present with symptoms of the [[obstructive hydrocephalus]], which includes:
*Other less frequent symptoms are:
**[[Vomiting]]
**Unilateral or bilateral [[visual impairment]] that starts as the loss of peripheral vision and eventually leads to [[blindness]].
**[[Sleepiness]]
**Involuntary eye ball movement
**[[Poor feeding]]
**Squinting
**[[Irritability]]
*Hypothalamic gliomas may present with symptoms of the [[diencephalic]] syndrome, which include:
**[[Seizures]]  
**Daytime sleeping
**Deficits in muscle tone and strength
**Decreased memory and [[brain]] function
Other less common symptoms are:
**Delayed growth
*Involuntary eye ball movement
**Loss of appetite and body fat
*Squinting
*[[Hypothalamic]] gliomas may present with symptoms of the [[diencephalic syndrome]], which includes:
**Daytime [[sleepiness]]
**Decreased [[memory]] and [[brain]] function
**[[Delayed growth]]
**Loss of appetite and [[loss of weight]]
*[[Precocious puberty]]- Due to involvement of hypothalamic-pituitary-gonadal axis precocious puberty may occur in 39 % of children with chiasmal optic nerve gliomas and NF-1.<ref name="pmid7869193">{{cite journal| author=Habiby R, Silverman B, Listernick R, Charrow J| title=Precocious puberty in children with neurofibromatosis type 1. | journal=J Pediatr | year= 1995 | volume= 126 | issue= 3 | pages= 364-7 | pmid=7869193 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7869193  }} </ref> In 10 to 20 percent of patients with optic pathway gliomas endocrinopathies due to hypothalamic extension are present.
*[[Precocious puberty]]- Due to involvement of hypothalamic-pituitary-gonadal axis precocious puberty may occur in 39 % of children with chiasmal optic nerve gliomas and NF-1.<ref name="pmid7869193">{{cite journal| author=Habiby R, Silverman B, Listernick R, Charrow J| title=Precocious puberty in children with neurofibromatosis type 1. | journal=J Pediatr | year= 1995 | volume= 126 | issue= 3 | pages= 364-7 | pmid=7869193 | doi= | pmc= | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=7869193  }} </ref> In 10 to 20 percent of patients with optic pathway gliomas endocrinopathies due to hypothalamic extension are present.


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[[Category:Neurology]]
[[Category:Neurology]]
[[Category:Ophthalmology]]
[[Category:Ophthalmology]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Ophthalmology]]
[[Category:Neurosurgery]]

Latest revision as of 14:47, 27 November 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Simrat Sarai, M.D. [2]

Overview

Symptoms of optic nerve glioma include proptosis, unilateral or bilateral visual impairment, involuntary eyeball movement, squinting, vomiting, irritability, poor feeding , seizures, deficits in muscle tone and strength, daytime sleepiness, decreased memory and brain function, weight loss, delayed growth and loss of appetite.

History

Common Symptoms

Decreased vision (63%) is usually evident and can be documented with visual field examination if the child is old enough. Eventually mass effects will also occur, with proptosis and even intracranial sequelae including symptoms of raised intracranial pressure, focal neurological deficits and hydrocephalus from distortion of the midbrain. Involvement of the hypothalamus may result in polyuria or polydipsia.[1]

Common symptoms of optic pathway gliomas include:

Other less common symptoms are:

  • Involuntary eye ball movement
  • Squinting
  • Hypothalamic gliomas may present with symptoms of the diencephalic syndrome, which includes:
  • Precocious puberty- Due to involvement of hypothalamic-pituitary-gonadal axis precocious puberty may occur in 39 % of children with chiasmal optic nerve gliomas and NF-1.[2] In 10 to 20 percent of patients with optic pathway gliomas endocrinopathies due to hypothalamic extension are present.

References

  1. Optic nerve glioma. Radiopedia(2015) http://radiopaedia.org/articles/optic-nerve-glioma Accessed on October 5 2015
  2. Habiby R, Silverman B, Listernick R, Charrow J (1995). "Precocious puberty in children with neurofibromatosis type 1". J Pediatr. 126 (3): 364–7. PMID 7869193.

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