Nuclear receptor coactivator 1: Difference between revisions

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{{Infobox_gene}}


The '''nuclear receptor coactivator 1''' ({{gene|NCOA1}}) is a transcriptional coregulatory protein that contains several [[nuclear receptor]] interacting domains and an intrinsic [[histone acetyltransferase]] activity ({{EC number|2.3.1.48}}).  NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors.  NCOA1, in turn, acylates histones, which makes downsteam DNA more accessible to transcription.  Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression.<ref name="Onate_1995">{{cite journal | vauthors = Oñate SA, Tsai SY, Tsai MJ, O'Malley BW | title = Sequence and characterization of a coactivator for the steroid hormone receptor superfamily | journal = Science | volume = 270 | issue = 5240 | pages = 1354–7 | year = 1995 | pmid = 7481822 | doi = 10.1126/science.270.5240.1354 }}</ref><ref name="Onate_1998">{{cite journal | vauthors = Onate SA, Boonyaratanakornkit V, Spencer TE, Tsai SY, Tsai MJ, Edwards DP, O'Malley BW | title = The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors | journal = J Biol Chem | volume = 273 | issue = 20 | pages = 12101–8 | year = 1998 | pmid = 9575154 | doi = 10.1074/jbc.273.20.12101 }}</ref>


NCOA1 is also frequently called steroid receptor coactivator-1 ('''SRC-1''').


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== Interactions ==
{{PBB_Controls
Nuclear receptor coactivator 1 possesses a basic helix-loop-helix (bHLH) domain and has been shown to [[Protein-protein interaction|interact]] with:
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* [[Androgen receptor]],<ref name = pmid15256534>{{cite journal | vauthors = Masiello D, Chen SY, Xu Y, Verhoeven MC, Choi E, Hollenberg AN, Balk SP | title = Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells | journal = Mol. Endocrinol. | volume = 18 | issue = 10 | pages = 2388–401 | date = Oct 2004 | pmid = 15256534 | doi = 10.1210/me.2003-0436 }}</ref><ref name = pmid12163482>{{cite journal | vauthors = Ueda T, Mawji NR, Bruchovsky N, Sadar MD | title = Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells | journal = J. Biol. Chem. | volume = 277 | issue = 41 | pages = 38087–94 | date = Oct 2002 | pmid = 12163482 | doi = 10.1074/jbc.M203313200 }}</ref><ref name = pmid10567563>{{cite journal | vauthors = Bevan CL, Hoare S, Claessens F, Heery DM, Parker MG | title = The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1 | journal = Mol. Cell. Biol. | volume = 19 | issue = 12 | pages = 8383–92 | date = Dec 1999 | pmid = 10567563 | pmc = 84931 | doi = 10.1128/mcb.19.12.8383}}</ref>
| update_protein_box = yes
* [[C-Fos]],<ref name = pmid10847592>{{cite journal | vauthors = Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW | title = Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2 | journal = Mol. Endocrinol. | volume = 14 | issue = 6 | pages = 915–25 | date = Jun 2000 | pmid = 10847592 | doi = 10.1210/mend.14.6.0471 }}</ref><ref name = pmid9642216>{{cite journal | vauthors = Lee SK, Kim HJ, Na SY, Kim TS, Choi HS, Im SY, Lee JW | title = Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits | journal = J. Biol. Chem. | volume = 273 | issue = 27 | pages = 16651–4 | date = Jul 1998 | pmid = 9642216 | doi = 10.1074/jbc.273.27.16651 }}</ref>
| update_summary = no
* [[C-jun]],<ref name = pmid10847592/><ref name = pmid9642216/><ref name = pmid10567404>{{cite journal | vauthors = Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW | title = A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo | journal = J. Biol. Chem. | volume = 274 | issue = 48 | pages = 34283–93 | date = Nov 1999 | pmid = 10567404 | doi = 10.1074/jbc.274.48.34283 }}</ref>
| update_citations = yes
* [[CIITA]],<ref name = pmid12933903>{{cite journal | vauthors = Tzortzakaki E, Spilianakis C, Zika E, Kretsovali A, Papamatheakis J | title = Steroid receptor coactivator 1 links the steroid and interferon gamma response pathways | journal = Mol. Endocrinol. | volume = 17 | issue = 12 | pages = 2509–18 | date = Dec 2003 | pmid = 12933903 | doi = 10.1210/me.2002-0439 }}</ref>
}}
* [[CREB-binding protein]],<ref name = pmid11113179>{{cite journal | vauthors = Sheppard HM, Harries JC, Hussain S, Bevan C, Heery DM | title = Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1 | journal = Mol. Cell. Biol. | volume = 21 | issue = 1 | pages = 39–50 | date = Jan 2001 | pmid = 11113179 | pmc = 86566 | doi = 10.1128/MCB.21.1.39-50.2001 }}</ref><ref name = pmid11971985>{{cite journal | vauthors = Wu RC, Qin J, Hashimoto Y, Wong J, Xu J, Tsai SY, Tsai MJ, O'Malley BW | title = Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase | journal = Mol. Cell. Biol. | volume = 22 | issue = 10 | pages = 3549–61 | date = May 2002 | pmid = 11971985 | pmc = 133790 | doi = 10.1128/MCB.22.10.3549-3561.2002 }}</ref>
 
* [[Cyclin D1]],<ref name = pmid9832502>{{cite journal | vauthors = Zwijsen RM, Buckle RS, Hijmans EM, Loomans CJ, Bernards R | title = Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1 | journal = Genes Dev. | volume = 12 | issue = 22 | pages = 3488–98 | date = Nov 1998 | pmid = 9832502 | pmc = 317237 | doi = 10.1101/gad.12.22.3488 }}</ref>
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* [[DDX17]],<ref name = pmid11250900>{{cite journal | vauthors = Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S | title = A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA | journal = EMBO J. | volume = 20 | issue = 6 | pages = 1341–52 | date = Mar 2001 | pmid = 11250900 | pmc = 145523 | doi = 10.1093/emboj/20.6.1341 }}</ref>
{{GNF_Protein_box
* [[DDX5]]<ref name = pmid11250900/> and
| image = PBB_Protein_NCOA1_image.jpg
* [[Estrogen receptor alpha]],<ref name = pmid11113179/><ref name = pmid11250900/><ref name = pmid11003650>{{cite journal | vauthors = DiRenzo J, Shang Y, Phelan M, Sif S, Myers M, Kingston R, Brown M | title = BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation | journal = Mol. Cell. Biol. | volume = 20 | issue = 20 | pages = 7541–9 | date = Oct 2000 | pmid = 11003650 | pmc = 86306 | doi = 10.1128/MCB.20.20.7541-7549.2000 }}</ref><ref name = pmid9427757>{{cite journal | vauthors = Kalkhoven E, Valentine JE, Heery DM, Parker MG | title = Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor | journal = EMBO J. | volume = 17 | issue = 1 | pages = 232–43 | date = Jan 1998 | pmid = 9427757 | pmc = 1170374 | doi = 10.1093/emboj/17.1.232 }}</ref><ref name = pmid11867769>{{cite journal | vauthors = Kang YK, Guermah M, Yuan CX, Roeder RG | title = The TRAP/Mediator coactivator complex interacts directly with estrogen receptors alpha and beta through the TRAP220 subunit and directly enhances estrogen receptor function in vitro | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 5 | pages = 2642–7 | date = Mar 2002 | pmid = 11867769 | pmc = 122401 | doi = 10.1073/pnas.261715899 }}</ref>
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1oj5.
* [[Glucocorticoid receptor]],<ref name = pmid11266503>{{cite journal | vauthors = Zilliacus J, Holter E, Wakui H, Tazawa H, Treuter E, Gustafsson JA | title = Regulation of glucocorticoid receptor activity by 14--3-3-dependent intracellular relocalization of the corepressor RIP140 | journal = Mol. Endocrinol. | volume = 15 | issue = 4 | pages = 501–11 | date = Apr 2001 | pmid = 11266503 | doi = 10.1210/mend.15.4.0624 }}</ref><ref name = pmid12118039>{{cite journal | vauthors = Kucera T, Waltner-Law M, Scott DK, Prasad R, Granner DK | title = A point mutation of the AF2 transactivation domain of the glucocorticoid receptor disrupts its interaction with steroid receptor coactivator 1 | journal = J. Biol. Chem. | volume = 277 | issue = 29 | pages = 26098–102 | date = Jul 2002 | pmid = 12118039 | doi = 10.1074/jbc.M204013200 }}</ref>
| Name = Nuclear receptor coactivator 1
* [[NFKB1]],<ref name = pmid10847592/><ref name = pmid9556555>{{cite journal | vauthors = Na SY, Lee SK, Han SJ, Choi HS, Im SY, Lee JW | title = Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kappaB-mediated transactivations | journal = J. Biol. Chem. | volume = 273 | issue = 18 | pages = 10831–4 | date = May 1998 | pmid = 9556555 | doi = 10.1074/jbc.273.18.10831 }}</ref>
| HGNCid = 7668
* [[PCAF]],<ref name = pmid9296499>{{cite journal | vauthors = Spencer TE, Jenster G, Burcin MM, Allis CD, Zhou J, Mizzen CA, McKenna NJ, Onate SA, Tsai SY, Tsai MJ, O'Malley BW | title = Steroid receptor coactivator-1 is a histone acetyltransferase | journal = Nature | volume = 389 | issue = 6647 | pages = 194–8 | date = Sep 1997 | pmid = 9296499 | doi = 10.1038/38304 }}</ref>
| Symbol = NCOA1
* [[PPARGC1A]],<ref name = pmid10558993>{{cite journal | vauthors = Puigserver P, Adelmant G, Wu Z, Fan M, Xu J, O'Malley B, Spiegelman BM | title = Activation of PPARgamma coactivator-1 through transcription factor docking | journal = Science | volume = 286 | issue = 5443 | pages = 1368–71 | date = Nov 1999 | pmid = 10558993 | doi = 10.1126/science.286.5443.1368 }}</ref>
| AltSymbols =; SRC1; F-SRC-1; MGC129719; MGC129720; NCoA-1; RIP160
* [[Peroxisome proliferator-activated receptor alpha]],<ref name = pmid9407140>{{cite journal | vauthors = Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M | title = p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha | journal = J. Biol. Chem. | volume = 272 | issue = 52 | pages = 33435–43 | date = Dec 1997 | pmid = 9407140 | doi = 10.1074/jbc.272.52.33435 }}</ref><ref name = pmid9626662>{{cite journal | vauthors = Treuter E, Albrektsen T, Johansson L, Leers J, Gustafsson JA | title = A regulatory role for RIP140 in nuclear receptor activation | journal = Mol. Endocrinol. | volume = 12 | issue = 6 | pages = 864–81 | date = Jun 1998 | pmid = 9626662 | doi = 10.1210/mend.12.6.0123 }}</ref>
| OMIM = 602691
* [[SNW1]],<ref name = pmid11514567>{{cite journal | vauthors = Zhang C, Baudino TA, Dowd DR, Tokumaru H, Wang W, MacDonald PN | title = Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription | journal = J. Biol. Chem. | volume = 276 | issue = 44 | pages = 40614–20 | date = Nov 2001 | pmid = 11514567 | doi = 10.1074/jbc.M106263200 }}</ref>
| ECnumber =
* [[STAT3]],<ref name = pmid11773079>{{cite journal | vauthors = Giraud S, Bienvenu F, Avril S, Gascan H, Heery DM, Coqueret O | title = Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a | journal = J. Biol. Chem. | volume = 277 | issue = 10 | pages = 8004–11 | date = Mar 2002 | pmid = 11773079 | doi = 10.1074/jbc.M111486200 }}</ref>
| Homologene = 7859
* [[STAT6]],<ref name = pmid11574547>{{cite journal | vauthors = Litterst CM, Pfitzner E | title = Transcriptional activation by STAT6 requires the direct interaction with NCoA-1 | journal = J. Biol. Chem. | volume = 276 | issue = 49 | pages = 45713–21 | date = Dec 2001 | pmid = 11574547 | doi = 10.1074/jbc.M108132200 }}</ref><ref name = pmid12138096>{{cite journal | vauthors = Litterst CM, Pfitzner E | title = An LXXLL motif in the transactivation domain of STAT6 mediates recruitment of NCoA-1/SRC-1 | journal = J. Biol. Chem. | volume = 277 | issue = 39 | pages = 36052–60 | date = Sep 2002 | pmid = 12138096 | doi = 10.1074/jbc.M203556200 }}</ref>
| MGIid = 1276523
* [[TRIP4]],<ref name = pmid10454579>{{cite journal | vauthors = Kim HJ, Yi JY, Sung HS, Moore DD, Jhun BH, Lee YC, Lee JW | title = Activating signal cointegrator 1, a novel transcription coactivator of nuclear receptors, and its cytosolic localization under conditions of serum deprivation | journal = Mol. Cell. Biol. | volume = 19 | issue = 9 | pages = 6323–32 | date = Sep 1999 | pmid = 10454579 | pmc = 84603 | doi = 10.1128/mcb.19.9.6323}}</ref> and
| GeneAtlas_image1 = PBB_GE_NCOA1_209106_at_tn.png
* [[Thyroid hormone receptor beta]].<ref name = pmid9751500>{{cite journal | vauthors = Liu Y, Takeshita A, Misiti S, Chin WW, Yen PM | title = Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors | journal = Endocrinology | volume = 139 | issue = 10 | pages = 4197–204 | date = Oct 1998 | pmid = 9751500 | doi = 10.1210/endo.139.10.6218 }}</ref><ref name = pmid9171239>{{cite journal | vauthors = Jeyakumar M, Tanen MR, Bagchi MK | title = Analysis of the functional role of steroid receptor coactivator-1 in ligand-induced transactivation by thyroid hormone receptor | journal = Mol. Endocrinol. | volume = 11 | issue = 6 | pages = 755–67 | date = Jun 1997 | pmid = 9171239 | doi = 10.1210/mend.11.6.0003 }}</ref>
| GeneAtlas_image2 = PBB_GE_NCOA1_209105_at_tn.png
{{Div col end}}
| GeneAtlas_image3 = PBB_GE_NCOA1_209107_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}} {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0004402 |text = histone acetyltransferase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008415 |text = acyltransferase activity}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}  
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8648
    | Hs_Ensembl = ENSG00000084676
    | Hs_RefseqProtein = NP_003734
    | Hs_RefseqmRNA = NM_003743
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 24660850
    | Hs_GenLoc_end = 24847075
    | Hs_Uniprot = Q15788
    | Mm_EntrezGene = 17977
    | Mm_Ensembl = ENSMUSG00000020647
    | Mm_RefseqmRNA = XM_001000135
    | Mm_RefseqProtein = XP_001000135
    | Mm_GenLoc_db =
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 4257418
    | Mm_GenLoc_end = 4491127
    | Mm_Uniprot = Q3U3A3
  }}
}}
 
The '''nuclear receptor coactivator 1''' ({{gene|NCOA1}}) is a transcriptional coregulatory protein which contains several [[nuclear receptor]] interacting domains and an intrinsic [[histone acetyltransferase]] activity ({{EC number|2.3.1.48}}). NCOA1 is recruited to DNA promotion sites by ligand activated nuclear receptors. NCOA1 in turn acylates histones which makes downsteam DNA more accessible to transcription. Hence NCOA1 assists nuclear receptors in the upregulation of DNA expression.<ref name="Onate_1995">{{cite journal |author=Onate SA, Tsai SY, Tsai MJ, O'Malley BW|title=Sequence and characterization of a coactivator for the steroid hormone receptor superfamily|journal= Science |volume= 270 |issue= 5240 |pages= 1354-7 |year= 1995| doi = 10.1126/science.270.5240.1354 |pmid= 7481822}}</ref><ref name="Onate_1998">{{cite journal |author=Onate SA, Boonyaratanakornkit V, Spencer TE, Tsai SY, Tsai MJ, Edwards DP, O'Malley BW|title=The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors|journal= J Biol Chem |volume= 273 |issue= 20 |pages= 12101-8 |year= 1998| doi =10.1074/jbc.273.20.12101 |pmid= 9575154}}</ref>
 
NCOA1 is also frequently called steroid receptor coactivator-1 ('''SRC-1''').


==External links==
== References ==
* {{MeshName|nuclear+receptor+coactivator+1}}
{{Reflist}}


==References==
== External links ==
{{reflist|2}}
* {{MeshName|nuclear+receptor+coactivator+1|3=nuclear receptor coactivator 1}}
* {{NURSA|C89}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Qi C, Zhu Y, Reddy JK | title = Peroxisome proliferator-activated receptors, coactivators, and downstream targets. | journal = Cell Biochem. Biophys. | volume = Spring | issue =  | pages = 187–204 | year = 2001 | pmid = 11330046 | doi =  | series = 32 }}
| citations =
*{{cite journal | author=Qi C, Zhu Y, Reddy JK |title=Peroxisome proliferator-activated receptors, coactivators, and downstream targets. |journal=Cell Biochem. Biophys. |volume=32 Spring |issue=  |pages= 187-204 |year= 2001 |pmid= 11330046 |doi=  }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=8648}}


{{Transcription coregulators}}
{{Transcription coregulators}}
[[Category:Transcription coregulators]]
[[Category:Transcription coregulators]]
 
[[Category:PAS-domain-containing proteins]]
 
[[it:Coattivatore del recettore nucleare 1]]
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Revision as of 16:28, 24 November 2016

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The nuclear receptor coactivator 1 (NCOA1) is a transcriptional coregulatory protein that contains several nuclear receptor interacting domains and an intrinsic histone acetyltransferase activity (EC 2.3.1.48). NCOA1 is recruited to DNA promotion sites by ligand-activated nuclear receptors. NCOA1, in turn, acylates histones, which makes downsteam DNA more accessible to transcription. Hence, NCOA1 assists nuclear receptors in the upregulation of DNA expression.[1][2]

NCOA1 is also frequently called steroid receptor coactivator-1 (SRC-1).

Interactions

Nuclear receptor coactivator 1 possesses a basic helix-loop-helix (bHLH) domain and has been shown to interact with:

References

  1. ↑ Oñate SA, Tsai SY, Tsai MJ, O'Malley BW (1995). "Sequence and characterization of a coactivator for the steroid hormone receptor superfamily". Science. 270 (5240): 1354–7. doi:10.1126/science.270.5240.1354. PMID 7481822.
  2. ↑ Onate SA, Boonyaratanakornkit V, Spencer TE, Tsai SY, Tsai MJ, Edwards DP, O'Malley BW (1998). "The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors". J Biol Chem. 273 (20): 12101–8. doi:10.1074/jbc.273.20.12101. PMID 9575154.
  3. ↑ Masiello D, Chen SY, Xu Y, Verhoeven MC, Choi E, Hollenberg AN, Balk SP (Oct 2004). "Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells". Mol. Endocrinol. 18 (10): 2388–401. doi:10.1210/me.2003-0436. PMID 15256534.
  4. ↑ Ueda T, Mawji NR, Bruchovsky N, Sadar MD (Oct 2002). "Ligand-independent activation of the androgen receptor by interleukin-6 and the role of steroid receptor coactivator-1 in prostate cancer cells". J. Biol. Chem. 277 (41): 38087–94. doi:10.1074/jbc.M203313200. PMID 12163482.
  5. ↑ Bevan CL, Hoare S, Claessens F, Heery DM, Parker MG (Dec 1999). "The AF1 and AF2 domains of the androgen receptor interact with distinct regions of SRC1". Mol. Cell. Biol. 19 (12): 8383–92. doi:10.1128/mcb.19.12.8383. PMC 84931. PMID 10567563.
  6. ↑ 6.0 6.1 6.2 Lee SK, Na SY, Jung SY, Choi JE, Jhun BH, Cheong J, Meltzer PS, Lee YC, Lee JW (Jun 2000). "Activating protein-1, nuclear factor-kappaB, and serum response factor as novel target molecules of the cancer-amplified transcription coactivator ASC-2". Mol. Endocrinol. 14 (6): 915–25. doi:10.1210/mend.14.6.0471. PMID 10847592.
  7. ↑ 7.0 7.1 Lee SK, Kim HJ, Na SY, Kim TS, Choi HS, Im SY, Lee JW (Jul 1998). "Steroid receptor coactivator-1 coactivates activating protein-1-mediated transactivations through interaction with the c-Jun and c-Fos subunits". J. Biol. Chem. 273 (27): 16651–4. doi:10.1074/jbc.273.27.16651. PMID 9642216.
  8. ↑ Lee SK, Anzick SL, Choi JE, Bubendorf L, Guan XY, Jung YK, Kallioniemi OP, Kononen J, Trent JM, Azorsa D, Jhun BH, Cheong JH, Lee YC, Meltzer PS, Lee JW (Nov 1999). "A nuclear factor, ASC-2, as a cancer-amplified transcriptional coactivator essential for ligand-dependent transactivation by nuclear receptors in vivo". J. Biol. Chem. 274 (48): 34283–93. doi:10.1074/jbc.274.48.34283. PMID 10567404.
  9. ↑ Tzortzakaki E, Spilianakis C, Zika E, Kretsovali A, Papamatheakis J (Dec 2003). "Steroid receptor coactivator 1 links the steroid and interferon gamma response pathways". Mol. Endocrinol. 17 (12): 2509–18. doi:10.1210/me.2002-0439. PMID 12933903.
  10. ↑ 10.0 10.1 Sheppard HM, Harries JC, Hussain S, Bevan C, Heery DM (Jan 2001). "Analysis of the steroid receptor coactivator 1 (SRC1)-CREB binding protein interaction interface and its importance for the function of SRC1". Mol. Cell. Biol. 21 (1): 39–50. doi:10.1128/MCB.21.1.39-50.2001. PMC 86566. PMID 11113179.
  11. ↑ Wu RC, Qin J, Hashimoto Y, Wong J, Xu J, Tsai SY, Tsai MJ, O'Malley BW (May 2002). "Regulation of SRC-3 (pCIP/ACTR/AIB-1/RAC-3/TRAM-1) Coactivator activity by I kappa B kinase". Mol. Cell. Biol. 22 (10): 3549–61. doi:10.1128/MCB.22.10.3549-3561.2002. PMC 133790. PMID 11971985.
  12. ↑ Zwijsen RM, Buckle RS, Hijmans EM, Loomans CJ, Bernards R (Nov 1998). "Ligand-independent recruitment of steroid receptor coactivators to estrogen receptor by cyclin D1". Genes Dev. 12 (22): 3488–98. doi:10.1101/gad.12.22.3488. PMC 317237. PMID 9832502.
  13. ↑ 13.0 13.1 13.2 Watanabe M, Yanagisawa J, Kitagawa H, Takeyama K, Ogawa S, Arao Y, Suzawa M, Kobayashi Y, Yano T, Yoshikawa H, Masuhiro Y, Kato S (Mar 2001). "A subfamily of RNA-binding DEAD-box proteins acts as an estrogen receptor alpha coactivator through the N-terminal activation domain (AF-1) with an RNA coactivator, SRA". EMBO J. 20 (6): 1341–52. doi:10.1093/emboj/20.6.1341. PMC 145523. PMID 11250900.
  14. ↑ DiRenzo J, Shang Y, Phelan M, Sif S, Myers M, Kingston R, Brown M (Oct 2000). "BRG-1 is recruited to estrogen-responsive promoters and cooperates with factors involved in histone acetylation". Mol. Cell. Biol. 20 (20): 7541–9. doi:10.1128/MCB.20.20.7541-7549.2000. PMC 86306. PMID 11003650.
  15. ↑ Kalkhoven E, Valentine JE, Heery DM, Parker MG (Jan 1998). "Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor". EMBO J. 17 (1): 232–43. doi:10.1093/emboj/17.1.232. PMC 1170374. PMID 9427757.
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  20. ↑ Spencer TE, Jenster G, Burcin MM, Allis CD, Zhou J, Mizzen CA, McKenna NJ, Onate SA, Tsai SY, Tsai MJ, O'Malley BW (Sep 1997). "Steroid receptor coactivator-1 is a histone acetyltransferase". Nature. 389 (6647): 194–8. doi:10.1038/38304. PMID 9296499.
  21. ↑ Puigserver P, Adelmant G, Wu Z, Fan M, Xu J, O'Malley B, Spiegelman BM (Nov 1999). "Activation of PPARgamma coactivator-1 through transcription factor docking". Science. 286 (5443): 1368–71. doi:10.1126/science.286.5443.1368. PMID 10558993.
  22. ↑ Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M (Dec 1997). "p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha". J. Biol. Chem. 272 (52): 33435–43. doi:10.1074/jbc.272.52.33435. PMID 9407140.
  23. ↑ Treuter E, Albrektsen T, Johansson L, Leers J, Gustafsson JA (Jun 1998). "A regulatory role for RIP140 in nuclear receptor activation". Mol. Endocrinol. 12 (6): 864–81. doi:10.1210/mend.12.6.0123. PMID 9626662.
  24. ↑ Zhang C, Baudino TA, Dowd DR, Tokumaru H, Wang W, MacDonald PN (Nov 2001). "Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription". J. Biol. Chem. 276 (44): 40614–20. doi:10.1074/jbc.M106263200. PMID 11514567.
  25. ↑ Giraud S, Bienvenu F, Avril S, Gascan H, Heery DM, Coqueret O (Mar 2002). "Functional interaction of STAT3 transcription factor with the coactivator NcoA/SRC1a". J. Biol. Chem. 277 (10): 8004–11. doi:10.1074/jbc.M111486200. PMID 11773079.
  26. ↑ Litterst CM, Pfitzner E (Dec 2001). "Transcriptional activation by STAT6 requires the direct interaction with NCoA-1". J. Biol. Chem. 276 (49): 45713–21. doi:10.1074/jbc.M108132200. PMID 11574547.
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  29. ↑ Liu Y, Takeshita A, Misiti S, Chin WW, Yen PM (Oct 1998). "Lack of coactivator interaction can be a mechanism for dominant negative activity by mutant thyroid hormone receptors". Endocrinology. 139 (10): 4197–204. doi:10.1210/endo.139.10.6218. PMID 9751500.
  30. ↑ Jeyakumar M, Tanen MR, Bagchi MK (Jun 1997). "Analysis of the functional role of steroid receptor coactivator-1 in ligand-induced transactivation by thyroid hormone receptor". Mol. Endocrinol. 11 (6): 755–67. doi:10.1210/mend.11.6.0003. PMID 9171239.

External links

Further reading

  • Qi C, Zhu Y, Reddy JK (2001). "Peroxisome proliferator-activated receptors, coactivators, and downstream targets". Cell Biochem. Biophys. 32. Spring: 187–204. PMID 11330046.
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