Nuclear receptor co-repressor 1

Nuclear receptor co-repressor 1
Identifiers
Symbols	NCOR1 ; KIAA1047; MGC104216; N-CoR; TRAC1; hCIT529I10; hN-CoR
External IDs	Template:OMIM5 Template:MGI HomoloGene: 38166
Gene ontology Molecular function Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO Cellular component Template:GNF GO Biological process Template:GNF GO Template:GNF GO Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE NCOR1 200854 at tn.png
File:PBB GE NCOR1 200855 at tn.png
File:PBB GE NCOR1 200856 x at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

The nuclear receptor co-repressor 1 (NCOR1) is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR1 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the down regulation of DNA expression.

NCOR1 is also sometimes referred to as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1).

External links

• nuclear+receptor+corepressor+1 at the US National Library of Medicine Medical Subject Headings (MeSH)

Further reading

• Minucci S, Pelicci PG (1999). "Retinoid receptors in health and disease: co-regulators and the chromatin connection". Semin. Cell Dev. Biol. 10 (2): 215–25. doi:10.1006/scdb.1999.0303. PMID 10441075.
• Hörlein AJ, Näär AM, Heinzel T; et al. (1995). "Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor". Nature. 377 (6548): 397–404. doi:10.1038/377397a0. PMID 7566114.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Downes M, Burke LJ, Bailey PJ, Muscat GE (1997). "Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors". Nucleic Acids Res. 24 (22): 4379–86. PMID 8948627.CS1 maint: Multiple names: authors list (link)
• Tagami T, Madison LD, Nagaya T, Jameson JL (1997). "Nuclear receptor corepressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone". Mol. Cell. Biol. 17 (5): 2642–8. PMID 9111334.CS1 maint: Multiple names: authors list (link)
• Zamir I, Dawson J, Lavinsky RM; et al. (1998). "Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex". Proc. Natl. Acad. Sci. U.S.A. 94 (26): 14400–5. PMID 9405624.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Burke LJ, Downes M, Laudet V, Muscat GE (1998). "Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA alpha". Mol. Endocrinol. 12 (2): 248–62. PMID 9482666.CS1 maint: Multiple names: authors list (link)
• Guidez F, Ivins S, Zhu J; et al. (1998). "Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia". Blood. 91 (8): 2634–42. PMID 9531570.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kao HY, Ordentlich P, Koyano-Nakagawa N; et al. (1998). "A histone deacetylase corepressor complex regulates the Notch signal transduction pathway". Genes Dev. 12 (15): 2269–77. PMID 9694793.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Laherty CD, Billin AN, Lavinsky RM; et al. (1998). "SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors". Mol. Cell. 2 (1): 33–42. PMID 9702189.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Wang J, Hoshino T, Redner RL; et al. (1998). "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10860–5. PMID 9724795.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Ordentlich P, Downes M, Xie W; et al. (1999). "Unique forms of human and mouse nuclear receptor corepressor SMRT". Proc. Natl. Acad. Sci. U.S.A. 96 (6): 2639–44. PMID 10077563.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Dowell P, Ishmael JE, Avram D; et al. (1999). "Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein". J. Biol. Chem. 274 (22): 15901–7. PMID 10336495.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Boutell JM, Thomas P, Neal JW; et al. (2000). "Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin". Hum. Mol. Genet. 8 (9): 1647–55. PMID 10441327.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Nagaya T, Chen KS, Fujieda M; et al. (1999). "Localization of the human nuclear receptor corepressor (hN-CoR) gene between the CMT1A and the SMS critical regions of chromosome 17p11.2". Genomics. 59 (3): 339–41. doi:10.1006/geno.1998.5694. PMID 10444336.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kikuno R, Nagase T, Ishikawa K; et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197–205. PMID 10470851.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Hu X, Lazar MA (1999). "The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors". Nature. 402 (6757): 93–6. doi:10.1038/47069. PMID 10573424.
• Huang EY, Zhang J, Miska EA; et al. (2000). "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway". Genes Dev. 14 (1): 45–54. PMID 10640275.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Morohoshi F, Mitani S, Mitsuhashi N; et al. (2000). "Structure and expression pattern of a human MTG8/ETO family gene, MTGR1". Gene. 241 (2): 287–95. PMID 10675041.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Masselink H, Bernards R (2000). "The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR". Oncogene. 19 (12): 1538–46. doi:10.1038/sj.onc.1203421. PMID 10734313.