Nuclear receptor co-repressor 1: Difference between revisions

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m (I added PPAR gamma to the list of interactions under PPAR alpha. This is what my professional research is in.)
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{{Infobox_gene}}
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The '''nuclear receptor co-repressor 1''' also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 ('''TRAC-1''') is a [[protein]] that in humans is encoded by the ''NCOR1'' [[gene]].<ref name="Horlein_1995">{{cite journal | vauthors = Hörlein AJ, Näär AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Söderström M, Glass CK | title = Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor | journal = Nature | volume = 377 | issue = 6548 | pages = 397–404 | date = October 1995 | pmid = 7566114 | doi = 10.1038/377397a0 }}</ref><ref name="pmid9724795">{{cite journal | vauthors = Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM | title = ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 18 | pages = 10860–5 | date = September 1998 | pmid = 9724795 | pmc = 27986 | doi = 10.1073/pnas.95.18.10860 }}</ref>
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NCOR1 is a transcriptional coregulatory protein which contains several [[nuclear receptor]] interacting domains.  In addition,  NCOR1 appears to recruit [[histone deacetylase]]s to DNA promoter regions.  Hence NCOR1 assists nuclear receptors in the down regulation of gene expression.<ref name="Horlein_1995"/><ref name="Wang_1998">{{cite journal | vauthors = Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM | title = ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex | journal = Proc Natl Acad Sci USA | volume = 95 | issue = 18 | pages = 10860–5 | year = 1998 | pmid = 9724795 | pmc = 27986 | doi = 10.1073/pnas.95.18.10860 }}</ref>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Nuclear receptor co-repressor 1
| HGNCid = 7672
| Symbol = NCOR1
| AltSymbols =; KIAA1047; MGC104216; N-CoR; TRAC1; hCIT529I10; hN-CoR
| OMIM = 600849
| ECnumber = 
| Homologene = 38166
| MGIid = 1349717
| GeneAtlas_image1 = PBB_GE_NCOR1_200854_at_tn.png
| GeneAtlas_image2 = PBB_GE_NCOR1_200855_at_tn.png
| GeneAtlas_image3 = PBB_GE_NCOR1_200856_x_at_tn.png
| Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006366 |text = transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0016568 |text = chromatin modification}} {{GNF_GO|id=GO:0045449 |text = regulation of transcription}} {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9611
    | Hs_Ensembl = ENSG00000141027
    | Hs_RefseqProtein = XP_001133522
    | Hs_RefseqmRNA = XM_001133522
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 15875984
    | Hs_GenLoc_end = 16059570
    | Hs_Uniprot = O75376
    | Mm_EntrezGene = 20185
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_011308
    | Mm_RefseqProtein = NP_035438
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
The '''nuclear receptor co-repressor 1''' ({{gene|NCOR1}}) is a transcriptional coregulatory protein which contains several [[nuclear receptor]] interacting domains.  In addition,  NCOR1 appears to recruit [[histone deacetylase]]s to DNA promoter regions.  Hence NCOR1 assists nuclear receptors in the down regulation of DNA expression.<ref name="Horlein_1995">{{cite journal |author=Horlein AJ, Naar AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Soderstrom M, Glass CK, Rosenfeld MG|title=Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor|journal= Nature |volume= 377 |issue= 6548 |pages= 397-404 |year= 1998| doi =10.1038/377397a0 |pmid= 7566114}}</ref><ref name="Wang_1998">{{cite journal |author=Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM|title=ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex|journal= Proc Natl Acad Sci U S A |volume= 95 |issue= 18 |pages= 10860-5 |year= 1998| doi = 10.1073/pnas.95.18.10860 |pmid= 9724795}}</ref>


NCOR1 is also sometimes referred to as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 ('''TRAC-1''').
Loss of function of this protein significantly increases the strength and power of mouse muscles.<ref name=Yamamoto_2011>{{cite journal | vauthors = Yamamoto H, Williams EG, Mouchiroud L, Cantó C, Fan W, Downes M, Héligon C, Barish GD, Desvergne B, Evans RM, Schoonjans K, Auwerx J | title = NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function | journal = Cell | volume = 147 | issue = 4 | pages = 827–839 | year = 2011 | pmid = 22078881 | doi = 10.1016/j.cell.2011.10.017 | pmc=3225739}}</ref>


==External links==
==Family==
* {{MeshName|nuclear+receptor+corepressor+1}}
It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is [[Nuclear receptor co-repressor 2]].<ref name=uniprotfam>UniProt [http://www.uniprot.org/uniprot/?query=family:%22N-CoR+nuclear+receptor+corepressors+family%22 Nuclear receptor corepressors family] Page accessed June 26, 2016</ref>


==References==
== Interactions ==
{{reflist|2}}
Nuclear receptor co-repressor 1 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[Androgen receptor]],<ref name = pmid15256534>{{cite journal | vauthors = Masiello D, Chen SY, Xu Y, Verhoeven MC, Choi E, Hollenberg AN, Balk SP | title = Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells | journal = Mol. Endocrinol. | volume = 18 | issue = 10 | pages = 2388–401 | date = October 2004 | pmid = 15256534 | doi = 10.1210/me.2003-0436 }}</ref><ref name = pmid14593076>{{cite journal | vauthors = Song LN, Coghlan M, Gelmann EP | title = Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor | journal = Mol. Endocrinol. | volume = 18 | issue = 1 | pages = 70–85 | date = January 2004 | pmid = 14593076 | doi = 10.1210/me.2003-0189 }}</ref><ref name = pmid12089345>{{cite journal | vauthors = Cheng S, Brzostek S, Lee SR, Hollenberg AN, Balk SP | title = Inhibition of the dihydrotestosterone-activated androgen receptor by nuclear receptor corepressor | journal = Mol. Endocrinol. | volume = 16 | issue = 7 | pages = 1492–501 | date = July 2002 | pmid = 12089345 | doi = 10.1210/mend.16.7.0870 }}</ref><ref name = pmid15598662>{{cite journal | vauthors = Hodgson MC, Astapova I, Cheng S, Lee LJ, Verhoeven MC, Choi E, Balk SP, Hollenberg AN | title = The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists | journal = J. Biol. Chem. | volume = 280 | issue = 8 | pages = 6511–9 | date = February 2005 | pmid = 15598662 | doi = 10.1074/jbc.M408972200 }}</ref>
* [[CHD1]],<ref name = pmid12890497>{{cite journal | vauthors = Tai HH, Geisterfer M, Bell JC, Moniwa M, Davie JR, Boucher L, McBurney MW | title = CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins | journal = Biochem. Biophys. Res. Commun. | volume = 308 | issue = 1 | pages = 170–6 | date = August 2003 | pmid = 12890497 | doi = 10.1016/s0006-291x(03)01354-8 }}</ref>
* [[Calcitriol receptor]]<ref name = pmid12460926>{{cite journal | vauthors = Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, Boehrer S, Hoelzer D, Ottmann OG, Pelicci PG, Nervi C, Ruthardt M | title = AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor | journal = Cancer Res. | volume = 62 | issue = 23 | pages = 7050–8 | date = December 2002 | pmid = 12460926 | doi =  }}</ref><ref name = pmid9878542>{{cite journal | vauthors = Tagami T, Lutz WH, Kumar R, Jameson JL | title = The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators | journal = Biochem. Biophys. Res. Commun. | volume = 253 | issue = 2 | pages = 358–63 | date = December 1998 | pmid = 9878542 | doi = 10.1006/bbrc.1998.9799 }}</ref>
* [[GPS2 (gene)|GPS2]],<ref name = pmid11931768/><ref name = pmid14527417/><ref name = pmid12628926/>
* [[Glucocorticoid receptor]],<ref name = pmid12569182>{{cite journal | vauthors = Stevens A, Garside H, Berry A, Waters C, White A, Ray D | title = Dissociation of steroid receptor coactivator 1 and nuclear receptor corepressor recruitment to the human glucocorticoid receptor by modification of the ligand-receptor interface: the role of tyrosine 735 | journal = Mol. Endocrinol. | volume = 17 | issue = 5 | pages = 845–59 | date = May 2003 | pmid = 12569182 | doi = 10.1210/me.2002-0320 }}</ref><ref name = pmid12011091>{{cite journal | vauthors = Schulz M, Eggert M, Baniahmad A, Dostert A, Heinzel T, Renkawitz R | title = RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding | journal = J. Biol. Chem. | volume = 277 | issue = 29 | pages = 26238–43 | date = July 2002 | pmid = 12011091 | doi = 10.1074/jbc.M203268200 }}</ref>
* [[HDAC3]],<ref name = pmid11931768/><ref name = pmid14527417/><ref name = pmid12628926/><ref name = pmid11466315/><ref name = pmid10944117/><ref name = pmid11804585>{{cite journal | vauthors = Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E | title = Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR | journal = Mol. Cell | volume = 9 | issue = 1 | pages = 45–57 | date = January 2002 | pmid = 11804585 | doi = 10.1016/s1097-2765(01)00429-4 }}</ref><ref name = pmid11013263>{{cite journal | vauthors = Underhill C, Qutob MS, Yee SP, Torchia J | title = A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1 | journal = J. Biol. Chem. | volume = 275 | issue = 51 | pages = 40463–70 | date = December 2000 | pmid = 11013263 | doi = 10.1074/jbc.M007864200 }}</ref>
* [[HDAC4]],<ref name = pmid11804585/><ref name = pmid10640275/>
* [[HDAC7A]],<ref name = pmid11466315>{{cite journal | vauthors = Fischle W, Dequiedt F, Fillion M, Hendzel MJ, Voelter W, Verdin E | title = Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo | journal = J. Biol. Chem. | volume = 276 | issue = 38 | pages = 35826–35 | date = September 2001 | pmid = 11466315 | doi = 10.1074/jbc.M104935200 }}</ref>
* [[HDAC9]],<ref name = pmid12590135>{{cite journal | vauthors = Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, Zelent A | title = The histone deacetylase 9 gene encodes multiple protein isoforms | journal = J. Biol. Chem. | volume = 278 | issue = 18 | pages = 16059–72 | date = May 2003 | pmid = 12590135 | doi = 10.1074/jbc.M212935200 }}</ref>
* [[HEY2]],<ref name = pmid11486045>{{cite journal | vauthors = Iso T, Sartorelli V, Poizat C, Iezzi S, Wu HY, Chung G, Kedes L, Hamamori Y | title = HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling | journal = Mol. Cell. Biol. | volume = 21 | issue = 17 | pages = 6080–9 | date = September 2001 | pmid = 11486045 | pmc = 87325 | doi = 10.1128/mcb.21.17.6080-6089.2001 }}</ref>
* [[Histone deacetylase 5]],<ref name = pmid11931768>{{cite journal | vauthors = Zhang J, Kalkum M, Chait BT, Roeder RG | title = The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2 | journal = Mol. Cell | volume = 9 | issue = 3 | pages = 611–23 | date = March 2002 | pmid = 11931768 | doi = 10.1016/s1097-2765(02)00468-9 }}</ref><ref name = pmid10640275>{{cite journal | vauthors = Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA | title = Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway | journal = Genes Dev. | volume = 14 | issue = 1 | pages = 45–54 | date = January 2000 | pmid = 10640275 | pmc = 316335 | doi =  }}</ref>
* [[MAP3K7IP2]],<ref name = pmid12150997>{{cite journal | vauthors = Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG | title = Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein | journal = Cell | volume = 110 | issue = 1 | pages = 55–67 | date = July 2002 | pmid = 12150997 | doi = 10.1016/S0092-8674(02)00809-7 }}</ref>
* [[MECP2]],<ref name = pmid11441023>{{cite journal | vauthors = Kokura K, Kaul SC, Wadhwa R, Nomura T, Khan MM, Shinagawa T, Yasukawa T, Colmenares C, Ishii S | title = The Ski protein family is required for MeCP2-mediated transcriptional repression | journal = J. Biol. Chem. | volume = 276 | issue = 36 | pages = 34115–21 | date = September 2001 | pmid = 11441023 | doi = 10.1074/jbc.M105747200 }}</ref>
* [[Peroxisome proliferator-activated receptor alpha]],<ref name = pmid10336495>{{cite journal | vauthors = Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M | title = Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein | journal = J. Biol. Chem. | volume = 274 | issue = 22 | pages = 15901–7 | date = May 1999 | pmid = 10336495 | doi = 10.1074/jbc.274.22.15901 }}</ref>
* [[Peroxisome proliferator-activated receptor gamma]]
* [[Promyelocytic leukemia protein]],<ref name = pmid11430826>{{cite journal | vauthors = Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi PP, Ishii S | title = Role of PML and PML-RARalpha in Mad-mediated transcriptional repression | journal = Mol. Cell | volume = 7 | issue = 6 | pages = 1233–43 | date = June 2001 | pmid = 11430826 | doi = 10.1016/s1097-2765(01)00257-x }}</ref>
* [[RUNX1T1]],<ref name = pmid11533236>{{cite journal | vauthors = Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, Downing JR, Meyers S, Hiebert SW | title = ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain | journal = Mol. Cell. Biol. | volume = 21 | issue = 19 | pages = 6470–83 | date = October 2001 | pmid = 11533236 | pmc = 99794 | doi = 10.1128/mcb.21.19.6470-6483.2001 }}</ref><ref name = pmid11113190>{{cite journal | vauthors = Zhang J, Hug BA, Huang EY, Chen CW, Gelmetti V, Maccarana M, Minucci S, Pelicci PG, Lazar MA | title = Oligomerization of ETO is obligatory for corepressor interaction | journal = Mol. Cell. Biol. | volume = 21 | issue = 1 | pages = 156–63 | date = January 2001 | pmid = 11113190 | pmc = 88789 | doi = 10.1128/MCB.21.1.156-163.2001 }}</ref>
* [[Retinoic acid receptor alpha]],<ref name = pmid10336495/><ref name = pmid9531570>{{cite journal | vauthors = Guidez F, Ivins S, Zhu J, Söderström M, Waxman S, Zelent A | title = Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia | journal = Blood | volume = 91 | issue = 8 | pages = 2634–42 | date = April 1998 | pmid = 9531570 | doi =  }}</ref>
* [[Retinoic acid receptor gamma]],<ref name = pmid10336495/>
* [[SAP30]],<ref name = pmid11013263/><ref name = pmid9702189>{{cite journal | vauthors = Laherty CD, Billin AN, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE, Eisenman RN | title = SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors | journal = Mol. Cell | volume = 2 | issue = 1 | pages = 33–42 | date = July 1998 | pmid = 9702189 | doi = 10.1016/s1097-2765(00)80111-2 }}</ref>
* [[TBL1XR1]],<ref name = pmid11931768/><ref name = pmid14527417>{{cite journal | vauthors = Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J | title = N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso | journal = Mol. Cell | volume = 12 | issue = 3 | pages = 723–34 | date = September 2003 | pmid = 14527417 | doi = 10.1016/j.molcel.2003.08.008 }}</ref><ref name = pmid12628926>{{cite journal | vauthors = Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J | title = Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1 | journal = EMBO J. | volume = 22 | issue = 6 | pages = 1336–46 | date = March 2003 | pmid = 12628926 | pmc = 151047 | doi = 10.1093/emboj/cdg120 }}</ref>
* [[TBL1X]],<ref name = pmid11931768/><ref name = pmid12628926/><ref name = pmid10944117>{{cite journal | vauthors = Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J | title = Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3 | journal = EMBO J. | volume = 19 | issue = 16 | pages = 4342–50 | date = August 2000 | pmid = 10944117 | pmc = 302030 | doi = 10.1093/emboj/19.16.4342 }}</ref><ref name = pmid10809664>{{cite journal | vauthors = Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R | title = A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness | journal = Genes Dev. | volume = 14 | issue = 9 | pages = 1048–57 | date = May 2000 | pmid = 10809664 | pmc = 316569 | doi =  10.1101/gad.14.9.1048}}</ref>  and
* [[ZBTB33]].<ref name = pmid14527417/>
{{Div col end}}


==Further reading==
== References ==
{{refbegin | 2}}
{{Reflist|35em}}
{{PBB_Further_reading
 
| citations =
== Further reading ==
*{{cite journal | author=Minucci S, Pelicci PG |title=Retinoid receptors in health and disease: co-regulators and the chromatin connection. |journal=Semin. Cell Dev. Biol. |volume=10 |issue= 2 |pages= 215-25 |year= 1999 |pmid= 10441075 |doi= 10.1006/scdb.1999.0303 }}
{{refbegin|35em}}
*{{cite journal | author=Hörlein AJ, Näär AM, Heinzel T, ''et al.'' |title=Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. |journal=Nature |volume=377 |issue= 6548 |pages= 397-404 |year= 1995 |pmid= 7566114 |doi= 10.1038/377397a0 }}
* {{cite journal | vauthors = Minucci S, Pelicci PG | title = Retinoid receptors in health and disease: co-regulators and the chromatin connection. | journal = Semin. Cell Dev. Biol. | volume = 10 | issue = 2 | pages = 215–25 | year = 1999 | pmid = 10441075 | doi = 10.1006/scdb.1999.0303 }}
*{{cite journal | author=Downes M, Burke LJ, Bailey PJ, Muscat GE |title=Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors. |journal=Nucleic Acids Res. |volume=24 |issue= 22 |pages= 4379-86 |year= 1997 |pmid= 8948627 |doi=  }}
* {{cite journal | vauthors = Downes M, Burke LJ, Bailey PJ, Muscat GE | title = Two receptor interaction domains in the corepressor, N-CoR/RIP13, are required for an efficient interaction with Rev-erbA alpha and RVR: physical association is dependent on the E region of the orphan receptors. | journal = Nucleic Acids Res. | volume = 24 | issue = 22 | pages = 4379–86 | year = 1997 | pmid = 8948627 | pmc = 146280 | doi = 10.1093/nar/24.22.4379 }}
*{{cite journal | author=Tagami T, Madison LD, Nagaya T, Jameson JL |title=Nuclear receptor corepressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone. |journal=Mol. Cell. Biol. |volume=17 |issue= 5 |pages= 2642-8 |year= 1997 |pmid= 9111334 |doi= }}
* {{cite journal | vauthors = Tagami T, Madison LD, Nagaya T, Jameson JL | title = Nuclear receptor corepressors activate rather than suppress basal transcription of genes that are negatively regulated by thyroid hormone. | journal = Mol. Cell. Biol. | volume = 17 | issue = 5 | pages = 2642–8 | year = 1997 | pmid = 9111334 | pmc = 232114 | doi =  }}
*{{cite journal | author=Zamir I, Dawson J, Lavinsky RM, ''et al.'' |title=Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 26 |pages= 14400-5 |year= 1998 |pmid= 9405624 |doi= }}
* {{cite journal | vauthors = Zamir I, Dawson J, Lavinsky RM, Glass CK, Rosenfeld MG, Lazar MA | title = Cloning and characterization of a corepressor and potential component of the nuclear hormone receptor repression complex. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 26 | pages = 14400–5 | year = 1998 | pmid = 9405624 | pmc = 24996 | doi = 10.1073/pnas.94.26.14400 }}
*{{cite journal | author=Burke LJ, Downes M, Laudet V, Muscat GE |title=Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA alpha. |journal=Mol. Endocrinol. |volume=12 |issue= 2 |pages= 248-62 |year= 1998 |pmid= 9482666 |doi=  }}
* {{cite journal | vauthors = Burke LJ, Downes M, Laudet V, Muscat GE | title = Identification and characterization of a novel corepressor interaction region in RVR and Rev-erbA alpha. | journal = Mol. Endocrinol. | volume = 12 | issue = 2 | pages = 248–62 | year = 1998 | pmid = 9482666 | doi = 10.1210/me.12.2.248 }}
*{{cite journal | author=Guidez F, Ivins S, Zhu J, ''et al.'' |title=Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia. |journal=Blood |volume=91 |issue= 8 |pages= 2634-42 |year= 1998 |pmid= 9531570 |doi= }}
* {{cite journal | vauthors = Guidez F, Ivins S, Zhu J, Söderström M, Waxman S, Zelent A | title = Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia. | journal = Blood | volume = 91 | issue = 8 | pages = 2634–42 | year = 1998 | pmid = 9531570 | doi =  }}
*{{cite journal | author=Kao HY, Ordentlich P, Koyano-Nakagawa N, ''et al.'' |title=A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. |journal=Genes Dev. |volume=12 |issue= 15 |pages= 2269-77 |year= 1998 |pmid= 9694793 |doi= }}
* {{cite journal | vauthors = Kao HY, Ordentlich P, Koyano-Nakagawa N, Tang Z, Downes M, Kintner CR, Evans RM, Kadesch T | title = A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. | journal = Genes Dev. | volume = 12 | issue = 15 | pages = 2269–77 | year = 1998 | pmid = 9694793 | pmc = 317043 | doi = 10.1101/gad.12.15.2269 }}
*{{cite journal | author=Laherty CD, Billin AN, Lavinsky RM, ''et al.'' |title=SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. |journal=Mol. Cell |volume=2 |issue= 1 |pages= 33-42 |year= 1998 |pmid= 9702189 |doi= }}
* {{cite journal | vauthors = Laherty CD, Billin AN, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE, Eisenman RN | title = SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors. | journal = Mol. Cell | volume = 2 | issue = 1 | pages = 33–42 | year = 1998 | pmid = 9702189 | doi = 10.1016/S1097-2765(00)80111-2 }}
*{{cite journal | author=Wang J, Hoshino T, Redner RL, ''et al.'' |title=ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 18 |pages= 10860-5 |year= 1998 |pmid= 9724795 |doi= }}
* {{cite journal | vauthors = Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM | title = ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 18 | pages = 10860–5 | year = 1998 | pmid = 9724795 | pmc = 27986 | doi = 10.1073/pnas.95.18.10860 }}
*{{cite journal | author=Ordentlich P, Downes M, Xie W, ''et al.'' |title=Unique forms of human and mouse nuclear receptor corepressor SMRT. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 6 |pages= 2639-44 |year= 1999 |pmid= 10077563 |doi= }}
* {{cite journal | vauthors = Ordentlich P, Downes M, Xie W, Genin A, Spinner NB, Evans RM | title = Unique forms of human and mouse nuclear receptor corepressor SMRT. | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 6 | pages = 2639–44 | year = 1999 | pmid = 10077563 | pmc = 15821 | doi = 10.1073/pnas.96.6.2639 }}
*{{cite journal | author=Dowell P, Ishmael JE, Avram D, ''et al.'' |title=Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein. |journal=J. Biol. Chem. |volume=274 |issue= 22 |pages= 15901-7 |year= 1999 |pmid= 10336495 |doi= }}
* {{cite journal | vauthors = Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M | title = Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein. | journal = J. Biol. Chem. | volume = 274 | issue = 22 | pages = 15901–7 | year = 1999 | pmid = 10336495 | doi = 10.1074/jbc.274.22.15901 }}
*{{cite journal | author=Boutell JM, Thomas P, Neal JW, ''et al.'' |title=Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin. |journal=Hum. Mol. Genet. |volume=8 |issue= 9 |pages= 1647-55 |year= 2000 |pmid= 10441327 |doi= }}
* {{cite journal | vauthors = Boutell JM, Thomas P, Neal JW, Weston VJ, Duce J, Harper PS, Jones AL | title = Aberrant interactions of transcriptional repressor proteins with the Huntington's disease gene product, huntingtin. | journal = Hum. Mol. Genet. | volume = 8 | issue = 9 | pages = 1647–55 | year = 2000 | pmid = 10441327 | doi = 10.1093/hmg/8.9.1647 }}
*{{cite journal | author=Nagaya T, Chen KS, Fujieda M, ''et al.'' |title=Localization of the human nuclear receptor corepressor (hN-CoR) gene between the CMT1A and the SMS critical regions of chromosome 17p11.2. |journal=Genomics |volume=59 |issue= 3 |pages= 339-41 |year= 1999 |pmid= 10444336 |doi= 10.1006/geno.1998.5694 }}
* {{cite journal | vauthors = Nagaya T, Chen KS, Fujieda M, Ohmori S, Richer JK, Horwitz KB, Lupski JR, Seo H | title = Localization of the human nuclear receptor corepressor (hN-CoR) gene between the CMT1A and the SMS critical regions of chromosome 17p11.2. | journal = Genomics | volume = 59 | issue = 3 | pages = 339–41 | year = 1999 | pmid = 10444336 | doi = 10.1006/geno.1998.5694 }}
*{{cite journal | author=Kikuno R, Nagase T, Ishikawa K, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197-205 |year= 1999 |pmid= 10470851 |doi= }}
* {{cite journal | vauthors = Kikuno R, Nagase T, Ishikawa K, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. | journal = DNA Res. | volume = 6 | issue = 3 | pages = 197–205 | year = 1999 | pmid = 10470851 | doi = 10.1093/dnares/6.3.197 }}
*{{cite journal | author=Hu X, Lazar MA |title=The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors. |journal=Nature |volume=402 |issue= 6757 |pages= 93-6 |year= 1999 |pmid= 10573424 |doi= 10.1038/47069 }}
* {{cite journal | vauthors = Hu X, Lazar MA | title = The CoRNR motif controls the recruitment of corepressors by nuclear hormone receptors. | journal = Nature | volume = 402 | issue = 6757 | pages = 93–6 | year = 1999 | pmid = 10573424 | doi = 10.1038/47069 }}
*{{cite journal | author=Huang EY, Zhang J, Miska EA, ''et al.'' |title=Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway. |journal=Genes Dev. |volume=14 |issue= 1 |pages= 45-54 |year= 2000 |pmid= 10640275 |doi= }}
* {{cite journal | vauthors = Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA | title = Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway. | journal = Genes Dev. | volume = 14 | issue = 1 | pages = 45–54 | year = 2000 | pmid = 10640275 | pmc = 316335 | doi = }}
*{{cite journal  | author=Morohoshi F, Mitani S, Mitsuhashi N, ''et al.'' |title=Structure and expression pattern of a human MTG8/ETO family gene, MTGR1. |journal=Gene |volume=241 |issue= 2 |pages= 287-95 |year= 2000 |pmid= 10675041 |doi=  }}
* {{cite journal | vauthors = Morohoshi F, Mitani S, Mitsuhashi N, Kitabayashi I, Takahashi E, Suzuki M, Munakata N, Ohki M | title = Structure and expression pattern of a human MTG8/ETO family gene, MTGR1. | journal = Gene | volume = 241 | issue = 2 | pages = 287–95 | year = 2000 | pmid = 10675041 | doi = 10.1016/S0378-1119(99)00481-3 }}
*{{cite journal | author=Masselink H, Bernards R |title=The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR. |journal=Oncogene |volume=19 |issue= 12 |pages= 1538-46 |year= 2000 |pmid= 10734313 |doi= 10.1038/sj.onc.1203421 }}
* {{cite journal | vauthors = Masselink H, Bernards R | title = The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR. | journal = Oncogene | volume = 19 | issue = 12 | pages = 1538–46 | year = 2000 | pmid = 10734313 | doi = 10.1038/sj.onc.1203421 }}
}}
{{refend}}
{{refend}}


{{biochem-stub}}
== External links ==
* {{MeshName|nuclear+receptor+corepressor+1|3=nuclear receptor corepressor 1}}
* {{NURSA|C97}}
 
{{Transcription coregulators}}
{{Transcription coregulators}}
[[Category:Transcription coregulators]]
[[Category:Transcription coregulators]]

Revision as of 23:47, 11 June 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
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View/Edit Human

The nuclear receptor co-repressor 1 also known as thyroid-hormone- and retinoic-acid-receptor-associated co-repressor 1 (TRAC-1) is a protein that in humans is encoded by the NCOR1 gene.[1][2]

NCOR1 is a transcriptional coregulatory protein which contains several nuclear receptor interacting domains. In addition, NCOR1 appears to recruit histone deacetylases to DNA promoter regions. Hence NCOR1 assists nuclear receptors in the down regulation of gene expression.[1][3]

Loss of function of this protein significantly increases the strength and power of mouse muscles.[4]

Family

It is a member of the family of nuclear receptor corepressors; the other human protein that is a member of that family is Nuclear receptor co-repressor 2.[5]

Interactions

Nuclear receptor co-repressor 1 has been shown to interact with:

References

  1. ↑ 1.0 1.1 Hörlein AJ, Näär AM, Heinzel T, Torchia J, Gloss B, Kurokawa R, Ryan A, Kamei Y, Söderström M, Glass CK (October 1995). "Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor". Nature. 377 (6548): 397–404. doi:10.1038/377397a0. PMID 7566114.
  2. ↑ Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM (September 1998). "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex". Proc. Natl. Acad. Sci. U.S.A. 95 (18): 10860–5. doi:10.1073/pnas.95.18.10860. PMC 27986. PMID 9724795.
  3. ↑ Wang J, Hoshino T, Redner RL, Kajigaya S, Liu JM (1998). "ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex". Proc Natl Acad Sci USA. 95 (18): 10860–5. doi:10.1073/pnas.95.18.10860. PMC 27986. PMID 9724795.
  4. ↑ Yamamoto H, Williams EG, Mouchiroud L, Cantó C, Fan W, Downes M, Héligon C, Barish GD, Desvergne B, Evans RM, Schoonjans K, Auwerx J (2011). "NCoR1 Is a Conserved Physiological Modulator of Muscle Mass and Oxidative Function". Cell. 147 (4): 827–839. doi:10.1016/j.cell.2011.10.017. PMC 3225739. PMID 22078881.
  5. ↑ UniProt Nuclear receptor corepressors family Page accessed June 26, 2016
  6. ↑ Masiello D, Chen SY, Xu Y, Verhoeven MC, Choi E, Hollenberg AN, Balk SP (October 2004). "Recruitment of beta-catenin by wild-type or mutant androgen receptors correlates with ligand-stimulated growth of prostate cancer cells". Mol. Endocrinol. 18 (10): 2388–401. doi:10.1210/me.2003-0436. PMID 15256534.
  7. ↑ Song LN, Coghlan M, Gelmann EP (January 2004). "Antiandrogen effects of mifepristone on coactivator and corepressor interactions with the androgen receptor". Mol. Endocrinol. 18 (1): 70–85. doi:10.1210/me.2003-0189. PMID 14593076.
  8. ↑ Cheng S, Brzostek S, Lee SR, Hollenberg AN, Balk SP (July 2002). "Inhibition of the dihydrotestosterone-activated androgen receptor by nuclear receptor corepressor". Mol. Endocrinol. 16 (7): 1492–501. doi:10.1210/mend.16.7.0870. PMID 12089345.
  9. ↑ Hodgson MC, Astapova I, Cheng S, Lee LJ, Verhoeven MC, Choi E, Balk SP, Hollenberg AN (February 2005). "The androgen receptor recruits nuclear receptor CoRepressor (N-CoR) in the presence of mifepristone via its N and C termini revealing a novel molecular mechanism for androgen receptor antagonists". J. Biol. Chem. 280 (8): 6511–9. doi:10.1074/jbc.M408972200. PMID 15598662.
  10. ↑ Tai HH, Geisterfer M, Bell JC, Moniwa M, Davie JR, Boucher L, McBurney MW (August 2003). "CHD1 associates with NCoR and histone deacetylase as well as with RNA splicing proteins". Biochem. Biophys. Res. Commun. 308 (1): 170–6. doi:10.1016/s0006-291x(03)01354-8. PMID 12890497.
  11. ↑ Puccetti E, Obradovic D, Beissert T, Bianchini A, Washburn B, Chiaradonna F, Boehrer S, Hoelzer D, Ottmann OG, Pelicci PG, Nervi C, Ruthardt M (December 2002). "AML-associated translocation products block vitamin D(3)-induced differentiation by sequestering the vitamin D(3) receptor". Cancer Res. 62 (23): 7050–8. PMID 12460926.
  12. ↑ Tagami T, Lutz WH, Kumar R, Jameson JL (December 1998). "The interaction of the vitamin D receptor with nuclear receptor corepressors and coactivators". Biochem. Biophys. Res. Commun. 253 (2): 358–63. doi:10.1006/bbrc.1998.9799. PMID 9878542.
  13. ↑ 13.0 13.1 13.2 13.3 13.4 Zhang J, Kalkum M, Chait BT, Roeder RG (March 2002). "The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2". Mol. Cell. 9 (3): 611–23. doi:10.1016/s1097-2765(02)00468-9. PMID 11931768.
  14. ↑ 14.0 14.1 14.2 14.3 Yoon HG, Chan DW, Reynolds AB, Qin J, Wong J (September 2003). "N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso". Mol. Cell. 12 (3): 723–34. doi:10.1016/j.molcel.2003.08.008. PMID 14527417.
  15. ↑ 15.0 15.1 15.2 15.3 Yoon HG, Chan DW, Huang ZQ, Li J, Fondell JD, Qin J, Wong J (March 2003). "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1". EMBO J. 22 (6): 1336–46. doi:10.1093/emboj/cdg120. PMC 151047. PMID 12628926.
  16. ↑ Stevens A, Garside H, Berry A, Waters C, White A, Ray D (May 2003). "Dissociation of steroid receptor coactivator 1 and nuclear receptor corepressor recruitment to the human glucocorticoid receptor by modification of the ligand-receptor interface: the role of tyrosine 735". Mol. Endocrinol. 17 (5): 845–59. doi:10.1210/me.2002-0320. PMID 12569182.
  17. ↑ Schulz M, Eggert M, Baniahmad A, Dostert A, Heinzel T, Renkawitz R (July 2002). "RU486-induced glucocorticoid receptor agonism is controlled by the receptor N terminus and by corepressor binding". J. Biol. Chem. 277 (29): 26238–43. doi:10.1074/jbc.M203268200. PMID 12011091.
  18. ↑ 18.0 18.1 Fischle W, Dequiedt F, Fillion M, Hendzel MJ, Voelter W, Verdin E (September 2001). "Human HDAC7 histone deacetylase activity is associated with HDAC3 in vivo". J. Biol. Chem. 276 (38): 35826–35. doi:10.1074/jbc.M104935200. PMID 11466315.
  19. ↑ 19.0 19.1 Li J, Wang J, Wang J, Nawaz Z, Liu JM, Qin J, Wong J (August 2000). "Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3". EMBO J. 19 (16): 4342–50. doi:10.1093/emboj/19.16.4342. PMC 302030. PMID 10944117.
  20. ↑ 20.0 20.1 Fischle W, Dequiedt F, Hendzel MJ, Guenther MG, Lazar MA, Voelter W, Verdin E (January 2002). "Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR". Mol. Cell. 9 (1): 45–57. doi:10.1016/s1097-2765(01)00429-4. PMID 11804585.
  21. ↑ 21.0 21.1 Underhill C, Qutob MS, Yee SP, Torchia J (December 2000). "A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1". J. Biol. Chem. 275 (51): 40463–70. doi:10.1074/jbc.M007864200. PMID 11013263.
  22. ↑ 22.0 22.1 Huang EY, Zhang J, Miska EA, Guenther MG, Kouzarides T, Lazar MA (January 2000). "Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway". Genes Dev. 14 (1): 45–54. PMC 316335. PMID 10640275.
  23. ↑ Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, Zelent A (May 2003). "The histone deacetylase 9 gene encodes multiple protein isoforms". J. Biol. Chem. 278 (18): 16059–72. doi:10.1074/jbc.M212935200. PMID 12590135.
  24. ↑ Iso T, Sartorelli V, Poizat C, Iezzi S, Wu HY, Chung G, Kedes L, Hamamori Y (September 2001). "HERP, a novel heterodimer partner of HES/E(spl) in Notch signaling". Mol. Cell. Biol. 21 (17): 6080–9. doi:10.1128/mcb.21.17.6080-6089.2001. PMC 87325. PMID 11486045.
  25. ↑ Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG (July 2002). "Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein". Cell. 110 (1): 55–67. doi:10.1016/S0092-8674(02)00809-7. PMID 12150997.
  26. ↑ Kokura K, Kaul SC, Wadhwa R, Nomura T, Khan MM, Shinagawa T, Yasukawa T, Colmenares C, Ishii S (September 2001). "The Ski protein family is required for MeCP2-mediated transcriptional repression". J. Biol. Chem. 276 (36): 34115–21. doi:10.1074/jbc.M105747200. PMID 11441023.
  27. ↑ 27.0 27.1 27.2 Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M (May 1999). "Identification of nuclear receptor corepressor as a peroxisome proliferator-activated receptor alpha interacting protein". J. Biol. Chem. 274 (22): 15901–7. doi:10.1074/jbc.274.22.15901. PMID 10336495.
  28. ↑ Khan MM, Nomura T, Kim H, Kaul SC, Wadhwa R, Shinagawa T, Ichikawa-Iwata E, Zhong S, Pandolfi PP, Ishii S (June 2001). "Role of PML and PML-RARalpha in Mad-mediated transcriptional repression". Mol. Cell. 7 (6): 1233–43. doi:10.1016/s1097-2765(01)00257-x. PMID 11430826.
  29. ↑ Amann JM, Nip J, Strom DK, Lutterbach B, Harada H, Lenny N, Downing JR, Meyers S, Hiebert SW (October 2001). "ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain". Mol. Cell. Biol. 21 (19): 6470–83. doi:10.1128/mcb.21.19.6470-6483.2001. PMC 99794. PMID 11533236.
  30. ↑ Zhang J, Hug BA, Huang EY, Chen CW, Gelmetti V, Maccarana M, Minucci S, Pelicci PG, Lazar MA (January 2001). "Oligomerization of ETO is obligatory for corepressor interaction". Mol. Cell. Biol. 21 (1): 156–63. doi:10.1128/MCB.21.1.156-163.2001. PMC 88789. PMID 11113190.
  31. ↑ Guidez F, Ivins S, Zhu J, Söderström M, Waxman S, Zelent A (April 1998). "Reduced retinoic acid-sensitivities of nuclear receptor corepressor binding to PML- and PLZF-RARalpha underlie molecular pathogenesis and treatment of acute promyelocytic leukemia". Blood. 91 (8): 2634–42. PMID 9531570.
  32. ↑ Laherty CD, Billin AN, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE, Eisenman RN (July 1998). "SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors". Mol. Cell. 2 (1): 33–42. doi:10.1016/s1097-2765(00)80111-2. PMID 9702189.
  33. ↑ Guenther MG, Lane WS, Fischle W, Verdin E, Lazar MA, Shiekhattar R (May 2000). "A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness". Genes Dev. 14 (9): 1048–57. doi:10.1101/gad.14.9.1048. PMC 316569. PMID 10809664.

Further reading

External links

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