Non-Hodgkin lymphoma classification: Difference between revisions

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Revision as of 18:58, 14 December 2018

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Non-Hodgkin lymphoma may be classified into subtypes according to updated WHO classification and rate of growth.

Classification

A. Updated WHO classification

Non-Hodgkin lymphoma may be classified according to updated WHO classification into 2 groups:^[1]

B-cell neoplasms
T-cell and putative NK-cell neoplasms

**Updated WHO classification of Non-Hodgkin lymphoma**
B-cell neoplasms	T-cell and putative NK-cell neoplasms
Precursor B-cell neoplasm	Precursor T-cell neoplasm
Precursor B-acute lymphoblastic leukemia / lymphoblastic lymphoma (LBL)	Precursor T-acute lymphoblastic leukemia / lymphoblastic lymphoma (LBL)
Mature B-cell neoplasms	Peripheral T-cell and NK-cell neoplasms
Chronic lymphocytic leukemia / small lymphocytic lymphoma	T-cell CLL / prolymphocytic leukemia
Monoclonal B-cell lymphocytosis
B-cell prolymphocytic leukemia	T-cell granular lymphocytic leukemia
Splenic marginal zone lymphoma (± villous lymphocytes) Splenic B-cell lymphoma/leukemia, unclassifiable 1. Splenic diffuse red pulp small B-cell lymphoma 2. Hairy cell leukemia-variant	Extranodal T-/NK-cell lymphoma, nasal type
Hairy cell leukemia	Enteropathy-type intestinal T-cell lymphoma
Lymphoplasmacytic lymphoma Waldenström's macroglubulinemia	Mycosis fungoides / Sézary syndrome
Monoclonal gammopathy of undetermined significance (MGUS), IgM IgG/A
µ heavy-chain disease ɣ heavy-chain disease α heavy-chain disease
Plasma cell myeloma (multiple myloma)
Solitary plasmacytoma of bone
Extraosseous plasmacytoma
Monoclonal immunoglobulin deposition diseases
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
Nodal marginal zone B-cell lymphoma (± monocytoid B-cells) pediatric Nodal marginal zone B-cell lymphoma	Angioimmunoblastic T-cell lymphoma
Follicular lymphoma In situ follicular neoplasia Duodenal-type follicular lymphoma Pediatric-type follicular lymphoma	Hepatosplenic gamma / delta T-cell lymphoma
Large B-cell lymphoma with IRF4 rearrangement
Primary cutaneous follicle center lymphoma	Subcutaneous panniculitis-like T-cell lymphoma
Mantle cell lymphoma In situ mantle cell neoplasia	Peripheral T-cell lymphoma, not otherwise characterized
Diffuse large B-cell lymphoma (DLBCL), NOS Germinal center B-cell type Activated B-cell type Primary DLBCL of the central nervous system (CNS) Primary cutaneous DLBCL, leg type DLBCL associated with chronic inflammation HHV81 DLBCL, NOS	Anaplastic large cell lymphoma, primary systemic type
T-cell/histiocyte-rich large B-cell lymphoma
EBV1 DLBCL, NOS EBV1 mucocutaneous ulcer	Adult T-cell lymphoma / leukemia (human T-lymphotrophic virus [HTLV] 1+)
Lymphomatoid granulomatosis
Primary mediastinal (thymic) large B-cell lymphoma	Aggressive NK-cell leukemia
Intravascular large B-cell lymphoma
ALK1 large B-cell lymphoma
Plasmablastic lymphoma
Primary effusion lymphoma
Burkitt lymphoma Burkitt-like lymphoma with 11q aberration	Anaplastic large cell lymphoma, primary cutaneous type
High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements High-grade B-cell lymphoma, NOS*
B-cell lymphoma, unclassifiable, with features intermediate between DLBCL and classical Hodgkin lymphoma

B. Classification based on rate of growth

Non-Hodgkin lymphoma may be classified based on rate of growth into 2 groups:^[2]

Low-grade or Indolent lymphoma
High-grade or Aggressive lymphoma

**Non-Hodgkin lymphoma classification**
Grade	Description
Low-grade or Indolent lymphoma	Tend to grow very slowly Tend to be widespread by the time they are diagnosed Often involving the bone marrow and spleen Often treated only when symptoms appear Can shrink or seem to disappear with treatment, but they tend to come back Can change into more aggressive lymphomas Have a fairly good prognosis
High-grade or Aggressive lymphoma	Grow quickly and tend to spread to lymph nodes or other organs throughout the body Cause symptoms and need treatment right away Can frequently be successfully treated with intensive chemotherapy treatment

Non-Hodgkin's Lymphoma

References

↑ National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/publications/pdq
↑ "Canadian Cancer Society Grades of non-Hodgkin lymphoma".

Template:Hematology

Template:WikiDoc Sources

[”cancer-1] National Cancer Institute. Physician Data Query Database 2015.http://www.cancer.gov/publications/pdq

[CCS-2] "Canadian Cancer Society Grades of non-Hodgkin lymphoma".

[1]

[2]

@@ Line 17: / Line 17: @@
 | style="padding: 5px 5px; background: #DCDCDC; text-align: center;" | '''Precursor T-cell neoplasm'''
 |-
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Precursor B-acute lymphoblastic leukemia / [[lymphoblastic lymphoma]] (LBL)
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | Precursor B-acute lymphoblastic leukemia / [[lymphoblastic lymphoma]] (LBL)
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Precursor T-acute lymphoblastic leukemia / [[lymphoblastic lymphoma]] (LBL)
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | Precursor T-acute lymphoblastic leukemia / [[lymphoblastic lymphoma]] (LBL)
 |-
 | style="padding: 5px 5px; background: #DCDCDC; text-align: center; font-weight: bold;" | Mature B-cell neoplasms
 | style="padding: 5px 5px; background: #DCDCDC; text-align: center; font-weight: bold;" | Peripheral T-cell and NK-cell neoplasms
 |-
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Chronic lymphocytic leukemia]] / [[Chronic lymphocytic leukemia|small lymphocytic lymphoma]]
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[Chronic lymphocytic leukemia]] / [[Chronic lymphocytic leukemia|small lymphocytic lymphoma]]
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | T-cell CLL / prolymphocytic leukemia
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | T-cell CLL / prolymphocytic leukemia
 |-
-|style="padding: 5px 5px; background: #F5F5F5; text-align: center;"|[[Monoclonal B-cell lymphocytosis]]
+|style="padding: 5px 5px; background: #F5F5F5; text-align: left;"|[[Monoclonal B-cell lymphocytosis]]
-|style="padding: 5px 5px; background: #F5F5F5; text-align: center;"|
+|style="padding: 5px 5px; background: #F5F5F5; text-align: left;"|
 |-
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[B-cell prolymphocytic leukemia]]
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[B-cell prolymphocytic leukemia]]
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[T-cell granular lymphocytic leukemia]]
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[T-cell granular lymphocytic leukemia]]
 |-
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Splenic marginal zone lymphoma]] (± villous lymphocytes)
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[Splenic marginal zone lymphoma]] (± villous lymphocytes)
 Splenic B-cell lymphoma/leukemia, unclassifiable
-. Splenic diffuse re pulp small B-cell lymphoma
+. Splenic diffuse red pulp small B-cell lymphoma
 . Hairy cell leukemia-variant
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Extranodal T-/NK-cell lymphoma, nasal type
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | Extranodal T-/NK-cell lymphoma, nasal type
 |-
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Hairy cell leukemia]]
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[Hairy cell leukemia]]
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Enteropathy-type intestinal T-cell lymphoma]]
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[Enteropathy-type intestinal T-cell lymphoma]]
 |-
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Lymphoplasmacytic lymphoma
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | Lymphoplasmacytic lymphoma
 [[Waldenström's macroglobulinemia|Waldenström's macroglubulinemia]]
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Mycosis fungoides]] / [[Sézary syndrome]]
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[Mycosis fungoides]] / [[Sézary syndrome]]
 |-
 |style="padding: 5px 5px; background: #F5F5F5; text-align: left;"|[[Monoclonal gammopathy of undetermined significance]] (MGUS),
 # IgM
 # IgG/A
-|style="padding: 5px 5px; background: #F5F5F5; text-align: center;"|
+|style="padding: 5px 5px; background: #F5F5F5; text-align: left;"|
 |-
-|style="padding: 5px 5px; background: #F5F5F5; text-align: center;"|µ heavy-chain disease
+|style="padding: 5px 5px; background: #F5F5F5; text-align: left;"|µ heavy-chain disease
 ɣ heavy-chain disease
 α heavy-chain disease
-|style="padding: 5px 5px; background: #F5F5F5; text-align: center;"|
+|style="padding: 5px 5px; background: #F5F5F5; text-align: left;"|
 |-
 |[[Multiple myeloma|Plasma cell myeloma]] (multiple myloma)
@@ Line 75: / Line 75: @@
 |
 |-
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Nodal marginal zone B-cell lymphoma]] (± monocytoid B-cells)
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[Nodal marginal zone B-cell lymphoma]] (± monocytoid B-cells)
 pediatric [[Nodal marginal zone B-cell lymphoma]]
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Angioimmunoblastic T-cell lymphoma
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | Angioimmunoblastic T-cell lymphoma
 |-
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Follicular lymphoma]]
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[Follicular lymphoma]]
 In situ follicular neoplasia
@@ Line 86: / Line 86: @@
 Pediatric-type follicular lymphoma
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Hepatosplenic gamma / delta T-cell lymphoma
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | Hepatosplenic gamma / delta T-cell lymphoma
 |-
-|style="padding: 5px 5px; background: #F5F5F5; text-align: center;"|Large B-cell lymphoma with IRF4 rearrangement
+|style="padding: 5px 5px; background: #F5F5F5; text-align: left;"|Large B-cell lymphoma with IRF4 rearrangement
-|style="padding: 5px 5px; background: #F5F5F5; text-align: center;"|
+|style="padding: 5px 5px; background: #F5F5F5; text-align: left;"|
 |-
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Primary cutaneous follicle centre lymphoma|Primary cutaneous follicle center lymphoma]]
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[Primary cutaneous follicle centre lymphoma|Primary cutaneous follicle center lymphoma]]
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Subcutaneous panniculitis-like T-cell lymphoma]]
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[Subcutaneous panniculitis-like T-cell lymphoma]]
 |-
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Mantle cell lymphoma]]
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[Mantle cell lymphoma]]
 In situ mantle cell neoplasia
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Peripheral T-cell lymphoma]], not otherwise characterized
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[Peripheral T-cell lymphoma]], not otherwise characterized
 |-
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Diffuse large B-cell lymphoma]] (DLBCL), NOS
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[Diffuse large B-cell lymphoma]] (DLBCL), NOS
 Germinal center B-cell type
@@ Line 112: / Line 112: @@
 | style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[Anaplastic large cell lymphoma]], primary systemic type
 |-
-|style="padding: 5px 5px; background: #F5F5F5; text-align: center;"|T-cell/histiocyte-rich large B-cell lymphoma
+|style="padding: 5px 5px; background: #F5F5F5; text-align: left;"|T-cell/histiocyte-rich large B-cell lymphoma
-|style="padding: 5px 5px; background: #F5F5F5; text-align: center;"|
+|style="padding: 5px 5px; background: #F5F5F5; text-align: left;"|
 |-
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | EBV1 DLBCL, NOS
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | EBV1 DLBCL, NOS
 EBV1 mucocutaneous ulcer
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Adult T-cell lymphoma / leukemia (human T-lymphotrophic virus [HTLV] 1+)
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | Adult T-cell lymphoma / leukemia (human T-lymphotrophic virus [HTLV] 1+)
 |-
 |[[Lymphomatoid granulomatosis]]
-|style="padding: 5px 5px; background: #F5F5F5; text-align: center;"|
+|style="padding: 5px 5px; background: #F5F5F5; text-align: left;"|
 |-
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" |[[Primary mediastinal large B-cell lymphoma|Primary mediastinal (thymic) large B-cell lymphoma]]
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Primary mediastinal large B-cell lymphoma|Primary mediastinal (thymic) large B-cell lymphoma]]
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Aggressive NK-cell leukemia]]
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[Aggressive NK-cell leukemia]]
 |-
 | style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |[[Intravascular large B-cell lymphoma]]
@@ Line 137: / Line 137: @@
 | style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |
 |-
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | [[Burkitt lymphoma]]
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | [[Burkitt lymphoma]]
 Burkitt-like lymphoma with 11q aberration
-| style="padding: 5px 5px; background: #F5F5F5; text-align: center;" | Anaplastic large cell lymphoma, primary cutaneous type
+| style="padding: 5px 5px; background: #F5F5F5; text-align: left;" | Anaplastic large cell lymphoma, primary cutaneous type
 |-
 | style="padding: 5px 5px; background: #F5F5F5; text-align: left;" |High-grade B-cell lymphoma, with MYC and BCL2 and/or BCL6 rearrangements

v t e Myeloid Hematological malignancy/leukemia histology (ICD-O 9590-9989, C81-C96, 200-208)
CFU-GM/ and other granulocytes	Template:Navbox subgroup
MEP	Template:Navbox subgroup
CFU-Mast	Mastocytoma (Mast cell leukemia, Mast cell sarcoma, Systemic mastocytosis)
Multiple/unknown	AML (Acute panmyelosis with myelofibrosis, Myeloid sarcoma) · MP (Myelofibrosis) · Acute biphenotypic leukaemia
See also hematology, lymphoid malignancy

Non-Hodgkin lymphoma classification: Difference between revisions

Revision as of 18:58, 14 December 2018

Overview

Classification

A. Updated WHO classification

B. Classification based on rate of growth

References

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