Non-Hodgkin lymphoma biopsy

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Preeti Singh, M.B.B.S.[2]

Overview

Lymph node or extranodal tissue biopsy is diagnostic of non-Hodgkin lymphoma.

Biopsy

  • Lymph node or extranodal tissue biopsy is diagnostic of non-Hodgkin lymphoma.[1][2][3][4]
  • Biopsy findings vary in morphologic features depending on the specific subtype.
  • The abnormal lymphocytes in the lymph node, bone marrow, or extranodal sites can be subdivided as small cleaved or noncleaved, intermediate, or large cell and can have a follicular or diffuse pattern.
  • Lymphomas usually alter the lymph node architecture, and the capsule is usually involved.

References

  1. Intragumtornchai T, Bunworasate U, Wudhikarn K, Lekhakula A, Julamanee J, Chansung K; et al. (2018). "Non-Hodgkin lymphoma in South East Asia: An analysis of the histopathology, clinical features, and survival from Thailand". Hematol Oncol. 36 (1): 28–36. doi:10.1002/hon.2392. PMID 28332735.
  2. Casulo C, Burack WR, Friedberg JW (2015). "Transformed follicular non-Hodgkin lymphoma". Blood. 125 (1): 40–7. doi:10.1182/blood-2014-04-516815. PMID 25499449.
  3. Bain BJ, Clark DM, Lampert IA, Wilkins BS, editors. Bone marrow pathology. 3 rd ed. UK: Blackwell Science Ltd; 2001.
  4. Bartl R, Frisch B, Burkhardt R, Jδger K, Pappenberger R, Hoffmann-Fezer G. Lymphoproliferations in bone marrow: i0 dentification and evaluation, classification and staging. J Clin Pathol 1984;37:233-54.