NEU3: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Sialidase-3''' is an [[enzyme]] that in humans is encoded by the ''NEU3'' [[gene]].<ref name="pmid10405317">{{cite journal | vauthors = Wada T, Yoshikawa Y, Tokuyama S, Kuwabara M, Akita H, Miyagi T | title = Cloning, expression, and chromosomal mapping of a human ganglioside sialidase | journal = Biochem Biophys Res Commun | volume = 261 | issue = 1 | pages = 21–7 | date = Aug 1999 | pmid = 10405317 | pmc = | doi = 10.1006/bbrc.1999.0973 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NEU3 sialidase 3 (membrane sialidase)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10825| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Sialidase 3 (membrane sialidase)
| HGNCid = 7760
| Symbol = NEU3
| AltSymbols =; FLJ12388; SIAL3
| OMIM = 604617
| ECnumber = 
| Homologene = 4847
| MGIid = 1355305
| GeneAtlas_image1 = PBB_GE_NEU3_216083_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_NEU3_206948_at_tn.png
| Function = {{GNF_GO|id=GO:0004308 |text = exo-alpha-sialidase activity}} {{GNF_GO|id=GO:0016798 |text = hydrolase activity, acting on glycosyl bonds}}
| Component = {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0006689 |text = ganglioside catabolic process}} {{GNF_GO|id=GO:0008152 |text = metabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10825
    | Hs_Ensembl = ENSG00000162139
    | Hs_RefseqProtein = NP_006647
    | Hs_RefseqmRNA = NM_006656
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 74377251
    | Hs_GenLoc_end = 74395777
    | Hs_Uniprot = Q9UQ49
    | Mm_EntrezGene = 50877
    | Mm_Ensembl = ENSMUSG00000035239
    | Mm_RefseqmRNA = NM_016720
    | Mm_RefseqProtein = NP_057929
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 99685520
    | Mm_GenLoc_end = 99702500
    | Mm_Uniprot = Q543I9
  }}
}}
'''Sialidase 3 (membrane sialidase)''', also known as '''NEU3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: NEU3 sialidase 3 (membrane sialidase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10825| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer.<ref name="entrez">{{cite web | title = Entrez Gene: NEU3 sialidase 3 (membrane sialidase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10825| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
NEU3 has been shown to [[Protein-protein interaction|interact]] with [[Grb2]].<ref name=pmid12730204>{{cite journal | vauthors = Sasaki A, Hata K, Suzuki S, Sawada M, Wada T, Yamaguchi K, Obinata M, Tateno H, Suzuki H, Miyagi T | title = Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice | journal = J. Biol. Chem. | volume = 278 | issue = 30 | pages = 27896–902 | date = Jul 2003 | pmid = 12730204 | doi = 10.1074/jbc.M212200200 }}</ref>
 
== References ==
{{reflist}}
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Hu H, Shioda T, Moriya C, Xin X, Hasan MK, Miyake K, Shimada T, Nagai Y | title = Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface | journal = J. Virol. | volume = 70 | issue = 11 | pages = 7462–70 | year = 1996 | pmid = 8892864 | pmc = 190813 | doi =  }}
| citations =
* {{cite journal | vauthors = Monti E, Bassi MT, Papini N, Riboni M, Manzoni M, Venerando B, Croci G, Preti A, Ballabio A, Tettamanti G, Borsani G | title = Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane | journal = Biochem. J. | volume = 349 | issue = Pt 1 | pages = 343–51 | year = 2001 | pmid = 10861246 | pmc = 1221155 | doi = 10.1042/0264-6021:3490343 }}
*{{cite journal | author=Hu H, Shioda T, Moriya C, ''et al.'' |title=Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface. |journal=J. Virol. |volume=70 |issue= 11 |pages= 7462-70 |year= 1996 |pmid= 8892864 |doi=  }}
* {{cite journal | vauthors = Wang Y, Yamaguchi K, Wada T, Hata K, Zhao X, Fujimoto T, Miyagi T | title = A close association of the ganglioside-specific sialidase Neu3 with caveolin in membrane microdomains | journal = J. Biol. Chem. | volume = 277 | issue = 29 | pages = 26252–9 | year = 2002 | pmid = 12011038 | doi = 10.1074/jbc.M110515200 }}
*{{cite journal | author=Wada T, Yoshikawa Y, Tokuyama S, ''et al.'' |title=Cloning, expression, and chromosomal mapping of a human ganglioside sialidase. |journal=Biochem. Biophys. Res. Commun. |volume=261 |issue= 1 |pages= 21-7 |year= 1999 |pmid= 10405317 |doi= 10.1006/bbrc.1999.0973 }}
* {{cite journal | vauthors = Kakugawa Y, Wada T, Yamaguchi K, Yamanami H, Ouchi K, Sato I, Miyagi T | title = Up-regulation of plasma membrane-associated ganglioside sialidase (Neu3) in human colon cancer and its involvement in apoptosis suppression | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 16 | pages = 10718–23 | year = 2002 | pmid = 12149448 | pmc = 125023 | doi = 10.1073/pnas.152597199 }}
*{{cite journal | author=Monti E, Bassi MT, Papini N, ''et al.'' |title=Identification and expression of NEU3, a novel human sialidase associated to the plasma membrane. |journal=Biochem. J. |volume=349 |issue= Pt 1 |pages= 343-51 |year= 2001 |pmid= 10861246 |doi= }}
* {{cite journal | vauthors = Hart ML, Saifuddin M, Uemura K, Bremer EG, Hooker B, Kawasaki T, Spear GT | title = High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1 | journal = AIDS Res. Hum. Retroviruses | volume = 18 | issue = 17 | pages = 1311–7 | year = 2003 | pmid = 12487819 | doi = 10.1089/088922202320886352 }}
*{{cite journal | author=Wang Y, Yamaguchi K, Wada T, ''et al.'' |title=A close association of the ganglioside-specific sialidase Neu3 with caveolin in membrane microdomains. |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 26252-9 |year= 2002 |pmid= 12011038 |doi= 10.1074/jbc.M110515200 }}
* {{cite journal | vauthors = Oehler C, Kopitz J, Cantz M | title = Substrate specificity and inhibitor studies of a membrane-bound ganglioside sialidase isolated from human brain tissue | journal = Biol. Chem. | volume = 383 | issue = 11 | pages = 1735–42 | year = 2003 | pmid = 12530538 | doi = 10.1515/BC.2002.194 }}
*{{cite journal | author=Kakugawa Y, Wada T, Yamaguchi K, ''et al.'' |title=Up-regulation of plasma membrane-associated ganglioside sialidase (Neu3) in human colon cancer and its involvement in apoptosis suppression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 16 |pages= 10718-23 |year= 2002 |pmid= 12149448 |doi= 10.1073/pnas.152597199 }}
* {{cite journal | vauthors = Sasaki A, Hata K, Suzuki S, Sawada M, Wada T, Yamaguchi K, Obinata M, Tateno H, Suzuki H, Miyagi T | title = Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice | journal = J. Biol. Chem. | volume = 278 | issue = 30 | pages = 27896–902 | year = 2003 | pmid = 12730204 | doi = 10.1074/jbc.M212200200 }}
*{{cite journal | author=Hart ML, Saifuddin M, Uemura K, ''et al.'' |title=High mannose glycans and sialic acid on gp120 regulate binding of mannose-binding lectin (MBL) to HIV type 1. |journal=AIDS Res. Hum. Retroviruses |volume=18 |issue= 17 |pages= 1311-7 |year= 2003 |pmid= 12487819 |doi= 10.1089/088922202320886352 }}
* {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nat. Biotechnol. | volume = 22 | issue = 6 | pages = 707–16 | year = 2005 | pmid = 15146197 | doi = 10.1038/nbt971 }}
*{{cite journal | author=Oehler C, Kopitz J, Cantz M |title=Substrate specificity and inhibitor studies of a membrane-bound ganglioside sialidase isolated from human brain tissue. |journal=Biol. Chem. |volume=383 |issue= 11 |pages= 1735-42 |year= 2003 |pmid= 12530538 |doi= }}
* {{cite journal | vauthors = Ha KT, Lee YC, Cho SH, Kim JK, Kim CH | title = Molecular characterization of membrane type and ganglioside-specific sialidase (Neu3) expressed in E. coli | journal = Mol. Cells | volume = 17 | issue = 2 | pages = 267–73 | year = 2004 | pmid = 15179041 | doi = }}
*{{cite journal | author=Sasaki A, Hata K, Suzuki S, ''et al.'' |title=Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice. |journal=J. Biol. Chem. |volume=278 |issue= 30 |pages= 27896-902 |year= 2003 |pmid= 12730204 |doi= 10.1074/jbc.M212200200 }}
* {{cite journal | vauthors = Stamatos NM, Liang F, Nan X, Landry K, Cross AS, Wang LX, Pshezhetsky AV | title = Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages | journal = FEBS J. | volume = 272 | issue = 10 | pages = 2545–56 | year = 2005 | pmid = 15885103 | doi = 10.1111/j.1742-4658.2005.04679.x }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Kato K, Shiga K, Yamaguchi K, Hata K, Kobayashi T, Miyazaki K, Saijo S, Miyagi T | title = Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling | journal = Biochem. J. | volume = 394 | issue = Pt 3 | pages = 647–56 | year = 2006 | pmid = 16241905 | pmc = 1383714 | doi = 10.1042/BJ20050737 }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Res. | volume = 16 | issue = 1 | pages = 55–65 | year = 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal | author=Ha KT, Lee YC, Cho SH, ''et al.'' |title=Molecular characterization of membrane type and ganglioside-specific sialidase (Neu3) expressed in E. coli. |journal=Mol. Cells |volume=17 |issue= 2 |pages= 267-73 |year= 2004 |pmid= 15179041 |doi= }}
* {{cite journal | vauthors = Ueno S, Saito S, Wada T, Yamaguchi K, Satoh M, Arai Y, Miyagi T | title = Plasma membrane-associated sialidase is up-regulated in renal cell carcinoma and promotes interleukin-6-induced apoptosis suppression and cell motility | journal = J. Biol. Chem. | volume = 281 | issue = 12 | pages = 7756–64 | year = 2006 | pmid = 16428383 | doi = 10.1074/jbc.M509668200 }}
*{{cite journal | author=Stamatos NM, Liang F, Nan X, ''et al.'' |title=Differential expression of endogenous sialidases of human monocytes during cellular differentiation into macrophages. |journal=FEBS J. |volume=272 |issue= 10 |pages= 2545-56 |year= 2005 |pmid= 15885103 |doi= 10.1111/j.1742-4658.2005.04679.x }}
* {{cite journal | vauthors = Yamaguchi K, Hata K, Wada T, Moriya S, Miyagi T | title = Epidermal growth factor-induced mobilization of a ganglioside-specific sialidase (NEU3) to membrane ruffles | journal = Biochem. Biophys. Res. Commun. | volume = 346 | issue = 2 | pages = 484–90 | year = 2006 | pmid = 16765317 | doi = 10.1016/j.bbrc.2006.05.136 }}
*{{cite journal  | author=Kato K, Shiga K, Yamaguchi K, ''et al.'' |title=Plasma-membrane-associated sialidase (NEU3) differentially regulates integrin-mediated cell proliferation through laminin- and fibronectin-derived signalling. |journal=Biochem. J. |volume=394 |issue= Pt 3 |pages= 647-56 |year= 2006 |pmid= 16241905 |doi= 10.1042/BJ20050737 }}
* {{cite journal | vauthors = Nan X, Carubelli I, Stamatos NM | title = Sialidase expression in activated human T lymphocytes influences production of IFN-gamma | journal = J. Leukoc. Biol. | volume = 81 | issue = 1 | pages = 284–96 | year = 2007 | pmid = 17028199 | doi = 10.1189/jlb.1105692 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
* {{cite journal | vauthors = Yoshizumi S, Suzuki S, Hirai M, Hinokio Y, Yamada T, Yamada T, Tsunoda U, Aburatani H, Yamaguchi K, Miyagi T, Oka Y | title = Increased hepatic expression of ganglioside-specific sialidase, NEU3, improves insulin sensitivity and glucose tolerance in mice | journal = Metab. Clin. Exp. | volume = 56 | issue = 3 | pages = 420–9 | year = 2007 | pmid = 17292733 | doi = 10.1016/j.metabol.2006.10.027 }}
*{{cite journal | author=Ueno S, Saito S, Wada T, ''et al.'' |title=Plasma membrane-associated sialidase is up-regulated in renal cell carcinoma and promotes interleukin-6-induced apoptosis suppression and cell motility. |journal=J. Biol. Chem. |volume=281 |issue= 12 |pages= 7756-64 |year= 2006 |pmid= 16428383 |doi= 10.1074/jbc.M509668200 }}
* {{cite journal | vauthors = Wada T, Hata K, Yamaguchi K, Shiozaki K, Koseki K, Moriya S, Miyagi T | title = A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells | journal = Oncogene | volume = 26 | issue = 17 | pages = 2483–90 | year = 2007 | pmid = 17334392 | doi = 10.1038/sj.onc.1210341 }}
*{{cite journal | author=Yamaguchi K, Hata K, Wada T, ''et al.'' |title=Epidermal growth factor-induced mobilization of a ganglioside-specific sialidase (NEU3) to membrane ruffles. |journal=Biochem. Biophys. Res. Commun. |volume=346 |issue= 2 |pages= 484-90 |year= 2006 |pmid= 16765317 |doi= 10.1016/j.bbrc.2006.05.136 }}
* {{cite journal | vauthors = Azuma Y, Sato H, Higai K, Matsumoto K | title = Enhanced expression of membrane-associated sialidase Neu3 decreases GD3 and increases GM3 on the surface of Jurkat cells during etoposide-induced apoptosis | journal = Biol. Pharm. Bull. | volume = 30 | issue = 9 | pages = 1680–4 | year = 2007 | pmid = 17827720 | doi = 10.1248/bpb.30.1680 }}
*{{cite journal | author=Nan X, Carubelli I, Stamatos NM |title=Sialidase expression in activated human T lymphocytes influences production of IFN-gamma. |journal=J. Leukoc. Biol. |volume=81 |issue= 1 |pages= 284-96 |year= 2007 |pmid= 17028199 |doi= 10.1189/jlb.1105692 }}
*{{cite journal | author=Yoshizumi S, Suzuki S, Hirai M, ''et al.'' |title=Increased hepatic expression of ganglioside-specific sialidase, NEU3, improves insulin sensitivity and glucose tolerance in mice. |journal=Metab. Clin. Exp. |volume=56 |issue= 3 |pages= 420-9 |year= 2007 |pmid= 17292733 |doi= 10.1016/j.metabol.2006.10.027 }}
*{{cite journal | author=Wada T, Hata K, Yamaguchi K, ''et al.'' |title=A crucial role of plasma membrane-associated sialidase in the survival of human cancer cells. |journal=Oncogene |volume=26 |issue= 17 |pages= 2483-90 |year= 2007 |pmid= 17334392 |doi= 10.1038/sj.onc.1210341 }}
*{{cite journal  | author=Azuma Y, Sato H, Higai K, Matsumoto K |title=Enhanced expression of membrane-associated sialidase Neu3 decreases GD3 and increases GM3 on the surface of Jurkat cells during etoposide-induced apoptosis. |journal=Biol. Pharm. Bull. |volume=30 |issue= 9 |pages= 1680-4 |year= 2007 |pmid= 17827720 |doi=  }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Sugar hydrolases}}
{{WikiDoc Sources}}
 
[[Category:Human proteins]]
 
 
{{gene-11-stub}}

Latest revision as of 12:51, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sialidase-3 is an enzyme that in humans is encoded by the NEU3 gene.[1][2]

Function

This gene product belongs to a family of glycohydrolytic enzymes which remove sialic acid residues from glycoproteins and glycolipids. It is localized in the plasma membrane, and its activity is specific for gangliosides. It may play a role in modulating the ganglioside content of the lipid bilayer.[2]

Interactions

NEU3 has been shown to interact with Grb2.[3]

References

  1. ↑ Wada T, Yoshikawa Y, Tokuyama S, Kuwabara M, Akita H, Miyagi T (Aug 1999). "Cloning, expression, and chromosomal mapping of a human ganglioside sialidase". Biochem Biophys Res Commun. 261 (1): 21–7. doi:10.1006/bbrc.1999.0973. PMID 10405317.
  2. ↑ 2.0 2.1 "Entrez Gene: NEU3 sialidase 3 (membrane sialidase)".
  3. ↑ Sasaki A, Hata K, Suzuki S, Sawada M, Wada T, Yamaguchi K, Obinata M, Tateno H, Suzuki H, Miyagi T (Jul 2003). "Overexpression of plasma membrane-associated sialidase attenuates insulin signaling in transgenic mice". J. Biol. Chem. 278 (30): 27896–902. doi:10.1074/jbc.M212200200. PMID 12730204.

Further reading


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