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{{Infobox_gene}}
{{PBB_Controls
'''Nuclear receptor coactivator 4''' is a [[protein]] that in humans is encoded by the ''NCOA4'' [[gene]].<ref name="pmid8290261">{{cite journal | vauthors = Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G, Fusco A | title = Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma | journal = Oncogene | volume = 9 | issue = 2 | pages = 509–16 | date = Feb 1994 | pmid = 8290261 | pmc =  | doi =  }}</ref><ref name="pmid8643607">{{cite journal | vauthors = Yeh S, Chang C | title = Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 11 | pages = 5517–21 | date = May 1996 | pmid = 8643607 | pmc = 39278 | doi = 10.1073/pnas.93.11.5517 }}</ref><ref>{{cite web | title = Entrez Gene: NCOA4 Nuclear receptor coactivator 4 |url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8031| accessdate = }}</ref>
| update_page = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =  
| Name = Nuclear receptor coactivator 4
| HGNCid = 7671
| Symbol = NCOA4
| AltSymbols =; ARA70; DKFZp762E1112; ELE1; PTC3; RFG
| OMIM = 601984
| ECnumber = 
| Homologene = 38052
| MGIid = 1350932
| GeneAtlas_image1 = PBB_GE_NCOA4_210774_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0050681 |text = androgen receptor binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0008584 |text = male gonad development}} {{GNF_GO|id=GO:0030521 |text = androgen receptor signaling pathway}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8031
    | Hs_Ensembl = ENSG00000138293
    | Hs_RefseqProtein = NP_005428
    | Hs_RefseqmRNA = NM_005437
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 10
    | Hs_GenLoc_start = 51235233
    | Hs_GenLoc_end = 51260740
    | Hs_Uniprot = Q13772
    | Mm_EntrezGene = 27057
    | Mm_Ensembl = ENSMUSG00000056234
    | Mm_RefseqmRNA = NM_001033988
    | Mm_RefseqProtein = NP_001029160
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 30999771
    | Mm_GenLoc_end = 31006385
    | Mm_Uniprot = 
  }}
}}
'''Nuclear receptor coactivator 4''', also known as '''NCOA4''', is a human [[gene]].<ref>{{cite web | title = Entrez Gene: NCOA4 Nuclear receptor coactivator 4 |url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8031| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
NCOA4 has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
* [[Androgen receptor]],<ref name = pmid8643607 /><ref name = pmid9892017>{{cite journal | vauthors = Alen P, Claessens F, Schoenmakers E, Swinnen JV, Verhoeven G, Rombauts W, Peeters B | title = Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform | journal = Molecular Endocrinology | volume = 13 | issue = 1 | pages = 117–28 | date = Jan 1999 | pmid = 9892017 | doi = 10.1210/mend.13.1.0214 }}</ref><ref name = pmid9636157>{{cite journal | vauthors = Miyamoto H, Yeh S, Wilding G, Chang C | title = Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 13 | pages = 7379–84 | date = Jun 1998 | pmid = 9636157 | pmc = 22623 | doi = 10.1073/pnas.95.13.7379 }}</ref><ref name = pmid11404460>{{cite journal | vauthors = Lin HK, Yeh S, Kang HY, Chang C | title = Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 13 | pages = 7200–5 | date = Jun 2001 | pmid = 11404460 | pmc = 34646 | doi = 10.1073/pnas.121173298 }}</ref><ref name = pmid10318905>{{cite journal | vauthors = Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C | title = From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 10 | pages = 5458–63 | date = May 1999 | pmid = 10318905 | pmc = 21881 | doi = 10.1073/pnas.96.10.5458 }}</ref><ref name = pmid11818501>{{cite journal | vauthors = Zhou ZX, He B, Hall SH, Wilson EM, French FS | title = Domain interactions between coregulator ARA(70) and the androgen receptor (AR) | journal = Molecular Endocrinology | volume = 16 | issue = 2 | pages = 287–300 | date = Feb 2002 | pmid = 11818501 | doi = 10.1210/mend.16.2.0765 }}</ref><ref name = pmid11779876>{{cite journal | vauthors = He B, Minges JT, Lee LW, Wilson EM | title = The FXXLF motif mediates androgen receptor-specific interactions with coregulators | journal = The Journal of Biological Chemistry | volume = 277 | issue = 12 | pages = 10226–35 | date = Mar 2002 | pmid = 11779876 | doi = 10.1074/jbc.M111975200 }}</ref><ref name = pmid10517667>{{cite journal | vauthors = Gao T, Brantley K, Bolu E, McPhaul MJ | title = RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays | journal = Molecular Endocrinology | volume = 13 | issue = 10 | pages = 1645–56 | date = Oct 1999 | pmid = 10517667 | doi = 10.1210/mend.13.10.0352 }}</ref><ref name = pmid12612084>{{cite journal | vauthors = He B, Wilson EM | title = Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs | journal = Molecular and Cellular Biology | volume = 23 | issue = 6 | pages = 2135–50 | date = Mar 2003 | pmid = 12612084 | pmc = 149467 | doi = 10.1128/mcb.23.6.2135-2150.2003 }}</ref> and
| section_title =  
* [[Peroxisome proliferator-activated receptor gamma]]<ref name = pmid10347167>{{cite journal | vauthors = Heinlein CA, Ting HJ, Yeh S, Chang C | title = Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma | journal = The Journal of Biological Chemistry | volume = 274 | issue = 23 | pages = 16147–52 | date = Jun 1999 | pmid = 10347167 | doi = 10.1074/jbc.274.23.16147 }}</ref>
| summary_text =  
}}


==References==
== See also ==
{{reflist|2}}
* [[Transcription coregulator]]
 
== References ==
{{reflist}}


==See also==
== External links ==
* [[Transcription coregulator]]
* {{NURSA|C92}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Minoletti F, Butti MG, Coronelli S, Miozzo M, Sozzi G, Pilotti S, Tunnacliffe A, Pierotti MA, Bongarzone I | title = The two genes generating RET/PTC3 are localized in chromosomal band 10q11.2 | journal = Genes, Chromosomes & Cancer | volume = 11 | issue = 1 | pages = 51–7 | date = Sep 1994 | pmid = 7529046 | doi = 10.1002/gcc.2870110108 }}
| citations =
* {{cite journal | vauthors = Jhiang SM, Smanik PA, Mazzaferri EL | title = Development of a single-step duplex RT-PCR detecting different forms of ret activation, and identification of the third form of in vivo ret activation in human papillary thyroid carcinoma | journal = Cancer Letters | volume = 78 | issue = 1-3 | pages = 69–76 | date = Apr 1994 | pmid = 8180971 | doi = 10.1016/0304-3835(94)90033-7 }}
*{{cite journal | author=Minoletti F, Butti MG, Coronelli S, ''et al.'' |title=The two genes generating RET/PTC3 are localized in chromosomal band 10q11.2. |journal=Genes Chromosomes Cancer |volume=11 |issue= 1 |pages= 51-7 |year= 1995 |pmid= 7529046 |doi= }}
* {{cite journal | vauthors = Bongarzone I, Butti MG, Coronelli S, Borrello MG, Santoro M, Mondellini P, Pilotti S, Fusco A, Della Porta G, Pierotti MA | title = Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas | journal = Cancer Research | volume = 54 | issue = 11 | pages = 2979–85 | date = Jun 1994 | pmid = 8187085 | doi =  }}
*{{cite journal | author=Jhiang SM, Smanik PA, Mazzaferri EL |title=Development of a single-step duplex RT-PCR detecting different forms of ret activation, and identification of the third form of in vivo ret activation in human papillary thyroid carcinoma. |journal=Cancer Lett. |volume=78 |issue= 1-3 |pages= 69-76 |year= 1994 |pmid= 8180971 |doi= }}
* {{cite journal | vauthors = Bongarzone I, Butti MG, Fugazzola L, Pacini F, Pinchera A, Vorontsova TV, Demidchik EP, Pierotti MA | title = Comparison of the breakpoint regions of ELE1 and RET genes involved in the generation of RET/PTC3 oncogene in sporadic and in radiation-associated papillary thyroid carcinomas | journal = Genomics | volume = 42 | issue = 2 | pages = 252–9 | date = Jun 1997 | pmid = 9192845 | doi = 10.1006/geno.1997.4685 }}
*{{cite journal | author=Bongarzone I, Butti MG, Coronelli S, ''et al.'' |title=Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas. |journal=Cancer Res. |volume=54 |issue= 11 |pages= 2979-85 |year= 1994 |pmid= 8187085 |doi=  }}
* {{cite journal | vauthors = Miyamoto H, Yeh S, Wilding G, Chang C | title = Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 13 | pages = 7379–84 | date = Jun 1998 | pmid = 9636157 | pmc = 22623 | doi = 10.1073/pnas.95.13.7379 }}
*{{cite journal | author=Santoro M, Dathan NA, Berlingieri MT, ''et al.'' |title=Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma. |journal=Oncogene |volume=9 |issue= 2 |pages= 509-16 |year= 1994 |pmid= 8290261 |doi= }}
* {{cite journal | vauthors = Alen P, Claessens F, Schoenmakers E, Swinnen JV, Verhoeven G, Rombauts W, Peeters B | title = Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform | journal = Molecular Endocrinology | volume = 13 | issue = 1 | pages = 117–28 | date = Jan 1999 | pmid = 9892017 | doi = 10.1210/mend.13.1.0214 }}
*{{cite journal | author=Yeh S, Chang C |title=Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 11 |pages= 5517-21 |year= 1996 |pmid= 8643607 |doi= }}
* {{cite journal | vauthors = Kang HY, Yeh S, Fujimoto N, Chang C | title = Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor | journal = The Journal of Biological Chemistry | volume = 274 | issue = 13 | pages = 8570–6 | date = Mar 1999 | pmid = 10085091 | doi = 10.1074/jbc.274.13.8570 }}
*{{cite journal | author=Bongarzone I, Butti MG, Fugazzola L, ''et al.'' |title=Comparison of the breakpoint regions of ELE1 and RET genes involved in the generation of RET/PTC3 oncogene in sporadic and in radiation-associated papillary thyroid carcinomas. |journal=Genomics |volume=42 |issue= 2 |pages= 252-9 |year= 1997 |pmid= 9192845 |doi= 10.1006/geno.1997.4685 }}
* {{cite journal | vauthors = Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C | title = From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 10 | pages = 5458–63 | date = May 1999 | pmid = 10318905 | pmc = 21881 | doi = 10.1073/pnas.96.10.5458 }}
*{{cite journal | author=Miyamoto H, Yeh S, Wilding G, Chang C |title=Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 13 |pages= 7379-84 |year= 1998 |pmid= 9636157 |doi= }}
* {{cite journal | vauthors = Heinlein CA, Ting HJ, Yeh S, Chang C | title = Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma | journal = The Journal of Biological Chemistry | volume = 274 | issue = 23 | pages = 16147–52 | date = Jun 1999 | pmid = 10347167 | doi = 10.1074/jbc.274.23.16147 }}
*{{cite journal | author=Alen P, Claessens F, Schoenmakers E, ''et al.'' |title=Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform. |journal=Mol. Endocrinol. |volume=13 |issue= 1 |pages= 117-28 |year= 1999 |pmid= 9892017 |doi= }}
* {{cite journal | vauthors = Gao T, Brantley K, Bolu E, McPhaul MJ | title = RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays | journal = Molecular Endocrinology | volume = 13 | issue = 10 | pages = 1645–56 | date = Oct 1999 | pmid = 10517667 | doi = 10.1210/mend.13.10.0352 }}
*{{cite journal | author=Kang HY, Yeh S, Fujimoto N, Chang C |title=Cloning and characterization of human prostate coactivator ARA54, a novel protein that associates with the androgen receptor. |journal=J. Biol. Chem. |volume=274 |issue= 13 |pages= 8570-6 |year= 1999 |pmid= 10085091 |doi= }}
* {{cite journal | vauthors = Hartley JL, Temple GF, Brasch MA | title = DNA cloning using in vitro site-specific recombination | journal = Genome Research | volume = 10 | issue = 11 | pages = 1788–95 | date = Nov 2000 | pmid = 11076863 | pmc = 310948 | doi = 10.1101/gr.143000 }}
*{{cite journal | author=Yeh S, Lin HK, Kang HY, ''et al.'' |title=From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 10 |pages= 5458-63 |year= 1999 |pmid= 10318905 |doi= }}
* {{cite journal | vauthors = Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A | title = Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs | journal = Genome Research | volume = 11 | issue = 3 | pages = 422–35 | date = Mar 2001 | pmid = 11230166 | pmc = 311072 | doi = 10.1101/gr.GR1547R }}
*{{cite journal | author=Heinlein CA, Ting HJ, Yeh S, Chang C |title=Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma. |journal=J. Biol. Chem. |volume=274 |issue= 23 |pages= 16147-52 |year= 1999 |pmid= 10347167 |doi= }}
* {{cite journal | vauthors = Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S | title = Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing | journal = EMBO Reports | volume = 1 | issue = 3 | pages = 287–92 | date = Sep 2000 | pmid = 11256614 | pmc = 1083732 | doi = 10.1093/embo-reports/kvd058 }}
*{{cite journal | author=Gao T, Brantley K, Bolu E, McPhaul MJ |title=RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays. |journal=Mol. Endocrinol. |volume=13 |issue= 10 |pages= 1645-56 |year= 1999 |pmid= 10517667 |doi= }}
* {{cite journal | vauthors = Lin HK, Yeh S, Kang HY, Chang C | title = Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 13 | pages = 7200–5 | date = Jun 2001 | pmid = 11404460 | pmc = 34646 | doi = 10.1073/pnas.121173298 }}
*{{cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788-95 |year= 2001 |pmid= 11076863 |doi= }}
* {{cite journal | vauthors = Basolo F, Giannini R, Monaco C, Melillo RM, Carlomagno F, Pancrazi M, Salvatore G, Chiappetta G, Pacini F, Elisei R, Miccoli P, Pinchera A, Fusco A, Santoro M | title = Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma | journal = The American Journal of Pathology | volume = 160 | issue = 1 | pages = 247–54 | date = Jan 2002 | pmid = 11786418 | pmc = 1867131 | doi = 10.1016/S0002-9440(10)64368-4 }}
*{{cite journal | author=Wiemann S, Weil B, Wellenreuther R, ''et al.'' |title=Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. |journal=Genome Res. |volume=11 |issue= 3 |pages= 422-35 |year= 2001 |pmid= 11230166 |doi= 10.1101/gr.154701 }}
* {{cite journal | vauthors = Zhou ZX, He B, Hall SH, Wilson EM, French FS | title = Domain interactions between coregulator ARA(70) and the androgen receptor (AR) | journal = Molecular Endocrinology | volume = 16 | issue = 2 | pages = 287–300 | date = Feb 2002 | pmid = 11818501 | doi = 10.1210/mend.16.2.0765 }}
*{{cite journal | author=Simpson JC, Wellenreuther R, Poustka A, ''et al.'' |title=Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. |journal=EMBO Rep. |volume=1 |issue= 3 |pages= 287-92 |year= 2001 |pmid= 11256614 |doi= 10.1093/embo-reports/kvd058 }}
* {{cite journal | vauthors = Thin TH, Kim E, Yeh S, Sampson ER, Chen YT, Collins LL, Basavappa R, Chang C | title = Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17beta-estradiol-induced androgen receptor transactivation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 39 | pages = 36499–508 | date = Sep 2002 | pmid = 12068007 | doi = 10.1074/jbc.M202824200 }}
*{{cite journal | author=Lin HK, Yeh S, Kang HY, Chang C |title=Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7200-5 |year= 2001 |pmid= 11404460 |doi= 10.1073/pnas.121173298 }}
*{{cite journal | author=Basolo F, Giannini R, Monaco C, ''et al.'' |title=Potent mitogenicity of the RET/PTC3 oncogene correlates with its prevalence in tall-cell variant of papillary thyroid carcinoma. |journal=Am. J. Pathol. |volume=160 |issue= 1 |pages= 247-54 |year= 2002 |pmid= 11786418 |doi= }}
*{{cite journal  | author=Zhou ZX, He B, Hall SH, ''et al.'' |title=Domain interactions between coregulator ARA(70) and the androgen receptor (AR). |journal=Mol. Endocrinol. |volume=16 |issue= 2 |pages= 287-300 |year= 2002 |pmid= 11818501 |doi=  }}
*{{cite journal  | author=Thin TH, Kim E, Yeh S, ''et al.'' |title=Mutations in the helix 3 region of the androgen receptor abrogate ARA70 promotion of 17beta-estradiol-induced androgen receptor transactivation. |journal=J. Biol. Chem. |volume=277 |issue= 39 |pages= 36499-508 |year= 2002 |pmid= 12068007 |doi= 10.1074/jbc.M202824200 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription coregulators}}
{{Transcription coregulators}}
{{DEFAULTSORT:Ncoa4}}
[[Category:Gene expression]]
[[Category:Gene expression]]
[[Category:Transcription coregulators]]
[[Category:Transcription coregulators]]
{{WikiDoc Sources}}

Revision as of 12:41, 5 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Nuclear receptor coactivator 4 is a protein that in humans is encoded by the NCOA4 gene.[1][2][3]

Interactions

NCOA4 has been shown to interact with:

See also

References

  1. ↑ Santoro M, Dathan NA, Berlingieri MT, Bongarzone I, Paulin C, Grieco M, Pierotti MA, Vecchio G, Fusco A (Feb 1994). "Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma". Oncogene. 9 (2): 509–16. PMID 8290261.
  2. ↑ 2.0 2.1 Yeh S, Chang C (May 1996). "Cloning and characterization of a specific coactivator, ARA70, for the androgen receptor in human prostate cells". Proceedings of the National Academy of Sciences of the United States of America. 93 (11): 5517–21. doi:10.1073/pnas.93.11.5517. PMC 39278. PMID 8643607.
  3. ↑ "Entrez Gene: NCOA4 Nuclear receptor coactivator 4".
  4. ↑ Alen P, Claessens F, Schoenmakers E, Swinnen JV, Verhoeven G, Rombauts W, Peeters B (Jan 1999). "Interaction of the putative androgen receptor-specific coactivator ARA70/ELE1alpha with multiple steroid receptors and identification of an internally deleted ELE1beta isoform". Molecular Endocrinology. 13 (1): 117–28. doi:10.1210/mend.13.1.0214. PMID 9892017.
  5. ↑ Miyamoto H, Yeh S, Wilding G, Chang C (Jun 1998). "Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells". Proceedings of the National Academy of Sciences of the United States of America. 95 (13): 7379–84. doi:10.1073/pnas.95.13.7379. PMC 22623. PMID 9636157.
  6. ↑ Lin HK, Yeh S, Kang HY, Chang C (Jun 2001). "Akt suppresses androgen-induced apoptosis by phosphorylating and inhibiting androgen receptor". Proceedings of the National Academy of Sciences of the United States of America. 98 (13): 7200–5. doi:10.1073/pnas.121173298. PMC 34646. PMID 11404460.
  7. ↑ Yeh S, Lin HK, Kang HY, Thin TH, Lin MF, Chang C (May 1999). "From HER2/Neu signal cascade to androgen receptor and its coactivators: a novel pathway by induction of androgen target genes through MAP kinase in prostate cancer cells". Proceedings of the National Academy of Sciences of the United States of America. 96 (10): 5458–63. doi:10.1073/pnas.96.10.5458. PMC 21881. PMID 10318905.
  8. ↑ Zhou ZX, He B, Hall SH, Wilson EM, French FS (Feb 2002). "Domain interactions between coregulator ARA(70) and the androgen receptor (AR)". Molecular Endocrinology. 16 (2): 287–300. doi:10.1210/mend.16.2.0765. PMID 11818501.
  9. ↑ He B, Minges JT, Lee LW, Wilson EM (Mar 2002). "The FXXLF motif mediates androgen receptor-specific interactions with coregulators". The Journal of Biological Chemistry. 277 (12): 10226–35. doi:10.1074/jbc.M111975200. PMID 11779876.
  10. ↑ Gao T, Brantley K, Bolu E, McPhaul MJ (Oct 1999). "RFG (ARA70, ELE1) interacts with the human androgen receptor in a ligand-dependent fashion, but functions only weakly as a coactivator in cotransfection assays". Molecular Endocrinology. 13 (10): 1645–56. doi:10.1210/mend.13.10.0352. PMID 10517667.
  11. ↑ He B, Wilson EM (Mar 2003). "Electrostatic modulation in steroid receptor recruitment of LXXLL and FXXLF motifs". Molecular and Cellular Biology. 23 (6): 2135–50. doi:10.1128/mcb.23.6.2135-2150.2003. PMC 149467. PMID 12612084.
  12. ↑ Heinlein CA, Ting HJ, Yeh S, Chang C (Jun 1999). "Identification of ARA70 as a ligand-enhanced coactivator for the peroxisome proliferator-activated receptor gamma". The Journal of Biological Chemistry. 274 (23): 16147–52. doi:10.1074/jbc.274.23.16147. PMID 10347167.

External links

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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