Myelofibrosis risk factors

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]

Overview

Myelofibrosis is a rare disorder and its common risk factors may be age, other myeloproliferative disorders, radiation, or industrial chemical exposure.

Risk Factors

Common risk factors for the development of myelofibrosis may include:[1]

  • Age: Myelofibrosis most commonly affects individuals in their 50s and 60s.
  • Other myeloproliferative disorder: Myelofibrosis may also develop secondary to essential thrombocythemia or polycythemia vera.
  • Radiation exposure: Individuals exposed to high levels of radiation (e.g. Thorotrast) have an increased risk of myelofibrosis.
  • Chemicals: Industrial chemicals, such as toluene and benzene, may have an increased risk of developing myelofibrosis.

References

  1. Risk factors for myelofibrosis. Mayo clinic 2016. http://www.mayoclinic.org/diseases-conditions/myelofibrosis/basics/risk-factors/con-20027210. Accessed on March 7, 2016

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