Myelofibrosis laboratory tests
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Sujit Routray, M.D. [2]
Overview
Peripheral blood smear and bone marrow examination helps in making the diagnosis of myelofibrosis. Various tests performed to aid in reaching the diagnosis include complete blood count, peripheral blood smear and bone marrrow examination, complete metabolic panel, and leukocyte alkaline phosphatase test.
Laboratory Tests
Laboratory findings consistent with the diagnosis of myelofibrosis include:[1][2]
Complete Blood Count
Peripheral Blood Smear
- Normochromic normocytic anemia
- Red cell poikilocytosis on blood film (tear-drop shaped RBCs)
- Nucleated red blood cells
- Presence of nucleated red blood cells suggests that immature cells are being released into the bloodstream in response to a very high demand for the bone marrow to produce new red blood cells.
Complete Metabolic Panel
- Raised levels of lactate dehydrogenase
Leukocyte Alkaline Phosphatase Test (LAP Test)
References
- ↑ Diagnosis of myelofibrosis. Wikipedia 2016. https://en.wikipedia.org/wiki/Myelofibrosis. Accessed on March 8, 2016
- ↑ Diagnosis of idiopathic myelofibrosis. Canadian cancer society 2016. http://www.cancer.ca/en/cancer-information/cancer-type/leukemia/leukemia/idiopathic-myelofibrosis/?region=on. Accessed on March 9, 2016