Methopholine

Methopholine
	File:Methopholine.svg
Clinical data
Synonyms	Methopholine
Legal status
Legal status	In general: legal;
Identifiers
	IUPAC name 1-[2-(4-chlorophenyl)ethyl]-6,7-dimethoxy -2-methyl-3,4-dihydro-1H-isoquinoline;
CAS Number	2154-02-1;
PubChem CID	16538;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C20H24ClNO2
Molar mass	345.87 g/mol

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Methopholine is an opioid analgesic drug invented in the 1960s.

Methopholine is an isoquinoline derivative which is not structurally related to most other opioids.^[1] It has around the same efficacy as an analgesic as codeine, and was evaluated for the treatment of postoperative pain, but never commercialised.^[2]^[3]^[4]

Methopholine is legal throughout the world.

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References

↑ Feinberg AP, Creese I, Snyder SH. The opiate receptor: a model explaining structure-activity relationships of opiate agonists and antagonists. Proceedings of the National Academy of Sciences U S A. 1976 Nov;73(11):4215-9.
↑ Moore J, Foldes FF, Davidson GM. An evaluation of the efficacy of methopholine for the relief of postoperative pain. American Journal of Medical Sciences. 1962 Sep;244:337-43.
↑ Cass LJ, Frederik WS. Methopholine, A New Analgesic Agent. American Journal of Medical Sciences. 1963 Nov;246:550-7.
↑ Sciorelli G. Plasma levels and renal excretion of unchanged methopholine in man. Experientia. 1967 Nov 15;23(11):934-6.

Template:Opioids Template:WikiDoc Sources

[1] Feinberg AP, Creese I, Snyder SH. The opiate receptor: a model explaining structure-activity relationships of opiate agonists and antagonists. Proceedings of the National Academy of Sciences U S A. 1976 Nov;73(11):4215-9.

[2] Moore J, Foldes FF, Davidson GM. An evaluation of the efficacy of methopholine for the relief of postoperative pain. American Journal of Medical Sciences. 1962 Sep;244:337-43.

[3] Cass LJ, Frederik WS. Methopholine, A New Analgesic Agent. American Journal of Medical Sciences. 1963 Nov;246:550-7.

[4] Sciorelli G. Plasma levels and renal excretion of unchanged methopholine in man. Experientia. 1967 Nov 15;23(11):934-6.

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Methopholine

References

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