Jump to: navigation, search
Clinical data
Legal status
Legal status
  • In general: legal
CAS Number
PubChem CID
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Molar mass345.87 g/mol

Methopholine is an opioid analgesic drug invented in the 1960s.

Methopholine is an isoquinoline derivative which is not structurally related to most other opioids.[1] It has around the same efficacy as an analgesic as codeine, and was evaluated for the treatment of postoperative pain, but never commercialised.[2][3][4]

Methopholine is legal throughout the world.


  1. Feinberg AP, Creese I, Snyder SH. The opiate receptor: a model explaining structure-activity relationships of opiate agonists and antagonists. Proceedings of the National Academy of Sciences U S A. 1976 Nov;73(11):4215-9.
  2. Moore J, Foldes FF, Davidson GM. An evaluation of the efficacy of methopholine for the relief of postoperative pain. American Journal of Medical Sciences. 1962 Sep;244:337-43.
  3. Cass LJ, Frederik WS. Methopholine, A New Analgesic Agent. American Journal of Medical Sciences. 1963 Nov;246:550-7.
  4. Sciorelli G. Plasma levels and renal excretion of unchanged methopholine in man. Experientia. 1967 Nov 15;23(11):934-6.