Metal responsive element gene transcriptions

Editor-In-Chief: Henry A. Hoff

Metal responsive elements (MRE)s, or TGC boxes, may occur in the core promoter of some human DNA genes.

TGC boxes

Notation: let the symbol MT stand for metallothionein.

"The metallothionein (MT) genes provide a good example of eucaryotic promoter architecture. MT genes specify the synthesis of low-molecular-weight metal-binding proteins. They are transcriptionally regulated by the metal ions cadmium and zinc (11), glucocorticoid hormones (18), interferon (14), interleukin-1 (22), and tumor promoters (2). The metal ion regulation of MTs is conferred by a short sequence element called the metal-responsive element (MRE [21]) or TGC box (31, 34), which functions as a metal ion-dependent enhancer."^[1]

Consensus sequences

"The promoter regulatory sequences are identified by homology to published GRE (21), MRE (35), and GC box (15) consensus sequences."^[1]

Here "is a consensus sequence for the MREs of the rat MT-1 gene."^[1] In the direction of transcription on the DNA template strand: 3'-CNNTGCRCYCGGGNC-5', where R = purine; Y = pyrimidine; and N = any nucleotide (nt).^[1]

"[T]hree potential metal response elements (MREs) [overlap] the E-boxes in the repeats, (TGCACGT with TGCRCNC being the consensus sequence; 17,18)."^[2]

The reproducible consensus sequence seems to be 3'-TGCRCNC-5', specifically 3'-TGC(A/G)CNC-5'.

MREs

Six MREs lie in the proximal promoter of the rat MT-1 gene upstream of the TATA box to almost -200 nts from the transcription start site.^[1]

Hypotheses

At least two human gene isoforms have their transcription initiated by an MRE.

Acknowledgements

The content on this page was first contributed by: Henry A. Hoff.

Initial content for this page in some instances came from Wikiversity.

References

↑ ^1.0 ^1.1 ^1.2 ^1.3 ^1.4 Robert D. Andersen, Susan J. Taplitz, Sandy Wong, Greg Bristol, Bill Larkin, and Harvey R. Herschman (1987). "Metal-Dependent Binding of a Factor In Vivo to the Metal-Responsive Elements of the Metallothionein 1 Gene Promoter". Molecular and Cellular Biology. 7 (10): 3574–81. doi:10.1128/MCB.7.10.3574 Check |doi= value (help). Retrieved 2013-04-15. Unknown parameter |month= ignored (help); Unknown parameter |pdf= ignored (help); zero width space character in |doi= at position 9 (help)
↑ Barbara Levinson, Rebecca Conant, Rhonda Schnur, Soma Das, Seymour Packman and Jane Gitschier (1996). "A Repeated Element in the Regulatory Region of the MNK Gene and Its Deletion in A Patient With Occipital Horn Syndrome". Human Molecular Genetics. 5 (11): 1737–42. doi:10.1093/hmg/5.11.1737. Retrieved 2013-04-15.

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transcriptions Ste12p gene transcriptions Sterol response element gene transcriptions Sucrose box gene transcriptions Synaptic Activity-Responsive Elements TACTAAC box gene transcriptions TAGteam gene transcriptions Tapetum box gene transcriptions TATA binding protein associated factor gene transcriptions TATA binding protein gene transcriptions TATA box gene transcriptions TAT box gene transcriptions TATC box gene transcriptions Tbf1 regulatory factor gene transcriptions T box gene transcriptions TCCACCATA element gene transcriptions TC element gene transcriptions TCT gene transcriptions TEA consensus sequence gene transcriptions Tec1p gene transcriptions Telomeric repeat DNA-binding factor gene transcriptions Tetradecanoylphorbol-13-acetate response element gene transcriptions TGF-β control elements (TCEs) TGF-β inhibitory elements (TIEs) Thyroid hormone response element gene transcriptions Transcriptional regulation Transcription bubble gene transcriptions Transcription factor gene 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Metal responsive element gene transcriptions

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