Marburg hemorrhagic fever history and symptoms

Jump to navigation Jump to search

Marburg hemorrhagic fever Microchapters

Home

Patient Information

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Marburg hemorrhagic fever from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic Criteria

History and Symptoms

Physical Examination

Laboratory Findings

Electrocardiogram

X-ray

Echocardiography and Ultrasound

CT scan

MRI

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Surgery

Primary Prevention

Secondary Prevention

Future or Investigational Therapies

Case Studies

Case #1

Marburg hemorrhagic fever history and symptoms On the Web

Most recent articles

Most cited articles

Review articles

CME Programs

Powerpoint slides

Images

American Roentgen Ray Society Images of Marburg hemorrhagic fever history and symptoms

All Images
X-rays
Echo & Ultrasound
CT Images
MRI

Ongoing Trials at Clinical Trials.gov

US National Guidelines Clearinghouse

NICE Guidance

FDA on Marburg hemorrhagic fever history and symptoms

CDC on Marburg hemorrhagic fever history and symptoms

Marburg hemorrhagic fever history and symptoms in the news

Blogs on Marburg hemorrhagic fever history and symptoms

Directions to Hospitals Treating Marburg hemorrhagic fever

Risk calculators and risk factors for Marburg hemorrhagic fever history and symptoms

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief:

Overview

History and Symptoms

Marburg hemorrhagic fever: Symptoms and Disease Progression
Generalisation Phase (Day 1 to Day 5)
  • Fever
  • Headache
  • Chills
  • Myalgia
  • Malaise
  • Fatigue
  • Nausea
  • Vomiting
  • Diarrhoea
  • Abdominal Pain
  • Conjunctivitis
  • Rash
  • Pharyngitis
Early Organ Phase (Day 6 to Day 13)
  • Fever
  • Bloody Diarrhoea(Malena)
  • Hematemesis
  • Exanthema
  • Petechiae?Ecchymoses
  • Muscosal hemorrhage
  • Visceral hemorrhage
  • Dyspnea
  • Conjunctival injection
  • Edema
  • Apathy/Depression
  • Irritability/aggression
Late Organ or Convalescence Phase (Day 14 to Day 21)
  • Fever
  • Obtundation
  • Dementia
  • Coma
  • Convulsions
  • Diffuse coagulopathy
  • Metabolic disturbances
  • Shock
  • Myalgia
  • Arthralgia
  • Hepatitis
  • Asthenia
  • Ocular disease
  • Psychosis
  • Social separation




Because many of the signs and symptoms of Marburg hemorrhagic fever are similar to those of other infectious diseases, such as malaria or typhoid, diagnosis of the disease can be difficult, especially if only a single case is involved. The incubation period (interval from infection to onset of symptoms) varies from 5 to 10 days. The disease is spread through bodily fluids, including blood, excrement, saliva, and vomit and a history of such contact should be solicited.

  • Early symptoms are often non-specific. They include the following:
  • After five days, a macropapular rash is often present on the trunk.
  • Later-stage Marburg infection is acute and can include the following:

Many patients develop severe hemorrhagic manifestations between 5 and 7 days, and fatal cases usually have some form of bleeding, often from multiple areas. Fresh blood in vomitus and feces is often accompanied by bleeding from the nose, gums, and vagina. Spontaneous bleeding at venipuncture sites can also occur. The time course varies but the disease lasts betweeen one and three weeks. The fatality rate ranges from 23 to 90%. Death occurs most often between 8 and 9 days after symptom onset, usually preceded by severe blood loss and shock. If a patient survives, recovery is usually prompt and complete, though it may be prolonged in some cases. Persistent symptoms may include inflammation or secondary infection of various organs, including: orchitis, hepatitis, transverse myelitis, uveitis, or parotitis. Involvement of the central nervous system can result in confusion, irritability, and aggression. Orchitis has been reported occasionally in the late phase of disease (15 days).

References

  1. "CDC special pathogins branch- Marburg page". Retrieved 2007-05-03.
  2. "World Health Orginization - Report after final death 2004-2005 outbreak". Retrieved 2007-05-03.