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| caption =
| Pfam = PF11594
| Pfam_clan = 
| InterPro = IPR021640
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'''Mediator of RNA polymerase II transcription subunit 28''' is an [[enzyme]] that in humans is encoded by the ''MED28'' [[gene]].<ref name="pmid11779215">{{cite journal | vauthors = Liu C, Zhang L, Shao ZM, Beatty P, Sartippour M, Lane TF, Barsky SH, Livingston E, Nguyen M | title = Identification of a novel endothelial-derived gene EG-1 | journal = Biochemical and Biophysical Research Communications | volume = 290 | issue = 1 | pages = 602–12 | date = Jan 2002 | pmid = 11779215 | pmc =  | doi = 10.1006/bbrc.2001.6119 }}</ref><ref name="pmid15467741">{{cite journal | vauthors = Wiederhold T, Lee MF, James M, Neujahr R, Smith N, Murthy A, Hartwig J, Gusella JF, Ramesh V | title = Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2 | journal = Oncogene | volume = 23 | issue = 54 | pages = 8815–25 | date = Nov 2004 | pmid = 15467741 | pmc =  | doi = 10.1038/sj.onc.1208110 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MED28 mediator of RNA polymerase II transcription, subunit 28 homolog (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80306| accessdate = }}</ref> It forms part of the [[Mediator (coactivator)|Mediator]] complex.


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{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Mediator of RNA polymerase II transcription, subunit 28 homolog (S. cerevisiae)
| HGNCid = 24628
| Symbol = MED28
| AltSymbols =; 1500003D12Rik; DKFZP434N185; EG1; magicin
| OMIM = 610311
| ECnumber = 
| Homologene = 11873
| MGIid = 1914249
| GeneAtlas_image1 = PBB_GE_MED28_218438_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005856 |text = cytoskeleton}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 80306
    | Hs_Ensembl = ENSG00000118579
    | Hs_RefseqProtein = NP_079481
    | Hs_RefseqmRNA = NM_025205
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 4
    | Hs_GenLoc_start = 17225371
    | Hs_GenLoc_end = 17235258
    | Hs_Uniprot = Q9H204
    | Mm_EntrezGene = 66999
    | Mm_Ensembl = ENSMUSG00000015804
    | Mm_RefseqmRNA = NM_025895
    | Mm_RefseqProtein = NP_080171
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 45808500
    | Mm_GenLoc_end = 45817532
    | Mm_Uniprot = Q920D3
  }}
}}
'''Mediator of RNA polymerase II transcription, subunit 28 homolog (S. cerevisiae)''', also known as '''MED28''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MED28 mediator of RNA polymerase II transcription, subunit 28 homolog (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=80306| accessdate = }}</ref>


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==References==
== Function ==
{{reflist|2}}
 
==Further reading==
Subunit Med28 of the Mediator may function as a scaffolding protein within Mediator by maintaining the stability of a submodule within the head module, and components of this submodule act together in a gene-regulatory programme to suppress [[smooth muscle]] [[cell differentiation]]. Thus, [[mammalia]]n Mediator subunit Med28 functions as a [[repressor]] of smooth muscle-cell differentiation, which could have implications for disorders associated with abnormalities in smooth [[muscle]] [[cell growth]] and differentiation, including atherosclerosis, asthma, hypertension, and smooth muscle [[tumour]]s.<ref name="pmid17848560">{{cite journal | vauthors = Beyer KS, Beauchamp RL, Lee MF, Gusella JF, Näär AM, Ramesh V | title = Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation | journal = The Journal of Biological Chemistry | volume = 282 | issue = 44 | pages = 32152–7 | date = Nov 2007 | pmid = 17848560 | doi = 10.1074/jbc.M706592200 }}</ref>
 
== Interactions ==
 
 
MED28 has been shown to [[Protein-protein interaction|interact]] with [[Merlin (protein)|Merlin]],<ref name=pmid15467741 /> [[Grb2]]<ref name=pmid15467741/> and [[MED26]].<ref name=pmid15175163>{{cite journal | vauthors = Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC | title = A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology | journal = Molecular Cell | volume = 14 | issue = 5 | pages = 685–91 | date = Jun 2004 | pmid = 15175163 | doi = 10.1016/j.molcel.2004.05.006 }}</ref>
 
== See also ==
*[[Mediator (coactivator)|Mediator complex]]
 
== References ==
{{reflist}}
{{InterPro content|IPR021640}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y | title = Protein-protein interaction panel using mouse full-length cDNAs | journal = Genome Research | volume = 11 | issue = 10 | pages = 1758–65 | date = Oct 2001 | pmid = 11591653 | pmc = 311163 | doi = 10.1101/gr.180101 }}
| citations =
* {{cite journal | vauthors = Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW | title = Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 17 | pages = 15123–7 | date = Apr 2003 | pmid = 12584197 | doi = 10.1074/jbc.C300054200 }}
*{{cite journal | author=Suzuki H, Fukunishi Y, Kagawa I, ''et al.'' |title=Protein-protein interaction panel using mouse full-length cDNAs. |journal=Genome Res. |volume=11 |issue= 10 |pages= 1758-65 |year= 2001 |pmid= 11591653 |doi= 10.1101/gr.180101 }}
* {{cite journal | vauthors = Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW | title = A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 7 | pages = 5846–51 | date = Feb 2004 | pmid = 14638676 | doi = 10.1074/jbc.M312523200 }}
*{{cite journal | author=Liu C, Zhang L, Shao ZM, ''et al.'' |title=Identification of a novel endothelial-derived gene EG-1. |journal=Biochem. Biophys. Res. Commun. |volume=290 |issue= 1 |pages= 602-12 |year= 2002 |pmid= 11779215 |doi= 10.1006/bbrc.2001.6119 }}
* {{cite journal | vauthors = Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC | title = A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology | journal = Molecular Cell | volume = 14 | issue = 5 | pages = 685–91 | date = Jun 2004 | pmid = 15175163 | doi = 10.1016/j.molcel.2004.05.006 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Lu M, Zhang L, Maul RS, Sartippour MR, Norris A, Whitelegge J, Rao JY, Brooks MN | title = The novel gene EG-1 stimulates cellular proliferation | journal = Cancer Research | volume = 65 | issue = 14 | pages = 6159–66 | date = Jul 2005 | pmid = 16024617 | doi = 10.1158/0008-5472.CAN-04-4016 }}
*{{cite journal  | author=Sato S, Tomomori-Sato C, Banks CA, ''et al.'' |title=Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 15123-7 |year= 2003 |pmid= 12584197 |doi= 10.1074/jbc.C300054200 }}
* {{cite journal | vauthors = Lee MF, Beauchamp RL, Beyer KS, Gusella JF, Ramesh V | title = Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation | journal = Biochemical and Biophysical Research Communications | volume = 348 | issue = 3 | pages = 826–31 | date = Sep 2006 | pmid = 16899217 | doi = 10.1016/j.bbrc.2006.07.126 }}
*{{cite journal | author=Tomomori-Sato C, Sato S, Parmely TJ, ''et al.'' |title=A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5846-51 |year= 2004 |pmid= 14638676 |doi= 10.1074/jbc.M312523200 }}
* {{cite journal | vauthors = Lu M, Zhang L, Sartippour MR, Norris AJ, Brooks MN | title = EG-1 interacts with c-Src and activates its signaling pathway | journal = International Journal of Oncology | volume = 29 | issue = 4 | pages = 1013–8 | date = Oct 2006 | pmid = 16964398 | doi = 10.3892/ijo.29.4.1013 }}
*{{cite journal | author=Sato S, Tomomori-Sato C, Parmely TJ, ''et al.'' |title=A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. |journal=Mol. Cell |volume=14 |issue= 5 |pages= 685-91 |year= 2004 |pmid= 15175163 |doi= 10.1016/j.molcel.2004.05.006 }}
* {{cite journal | vauthors = Beyer KS, Beauchamp RL, Lee MF, Gusella JF, Näär AM, Ramesh V | title = Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation | journal = The Journal of Biological Chemistry | volume = 282 | issue = 44 | pages = 32152–7 | date = Nov 2007 | pmid = 17848560 | doi = 10.1074/jbc.M706592200 }}
*{{cite journal | author=Wiederhold T, Lee MF, James M, ''et al.'' |title=Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2. |journal=Oncogene |volume=23 |issue= 54 |pages= 8815-25 |year= 2005 |pmid= 15467741 |doi= 10.1038/sj.onc.1208110 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Lu M, Zhang L, Maul RS, ''et al.'' |title=The novel gene EG-1 stimulates cellular proliferation. |journal=Cancer Res. |volume=65 |issue= 14 |pages= 6159-66 |year= 2005 |pmid= 16024617 |doi= 10.1158/0008-5472.CAN-04-4016 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  | author=Lee MF, Beauchamp RL, Beyer KS, ''et al.'' |title=Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation. |journal=Biochem. Biophys. Res. Commun. |volume=348 |issue= 3 |pages= 826-31 |year= 2006 |pmid= 16899217 |doi= 10.1016/j.bbrc.2006.07.126 }}
*{{cite journal | author=Lu M, Zhang L, Sartippour MR, ''et al.'' |title=EG-1 interacts with c-Src and activates its signaling pathway. |journal=Int. J. Oncol. |volume=29 |issue= 4 |pages= 1013-8 |year= 2006 |pmid= 16964398 |doi= }}
*{{cite journal | author=Beyer KS, Beauchamp RL, Lee MF, ''et al.'' |title=Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation. |journal=J. Biol. Chem. |volume=282 |issue= 44 |pages= 32152-7 |year= 2007 |pmid= 17848560 |doi= 10.1074/jbc.M706592200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
 
{{WikiDoc Sources}}
[[Category:Protein families]]
 
 
{{gene-4-stub}}

Latest revision as of 03:19, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human
Med28
Identifiers
SymbolMed28
PfamPF11594
InterProIPR021640

Mediator of RNA polymerase II transcription subunit 28 is an enzyme that in humans is encoded by the MED28 gene.[1][2][3] It forms part of the Mediator complex.


Function

Subunit Med28 of the Mediator may function as a scaffolding protein within Mediator by maintaining the stability of a submodule within the head module, and components of this submodule act together in a gene-regulatory programme to suppress smooth muscle cell differentiation. Thus, mammalian Mediator subunit Med28 functions as a repressor of smooth muscle-cell differentiation, which could have implications for disorders associated with abnormalities in smooth muscle cell growth and differentiation, including atherosclerosis, asthma, hypertension, and smooth muscle tumours.[4]

Interactions

MED28 has been shown to interact with Merlin,[2] Grb2[2] and MED26.[5]

See also

References

  1. ↑ Liu C, Zhang L, Shao ZM, Beatty P, Sartippour M, Lane TF, Barsky SH, Livingston E, Nguyen M (Jan 2002). "Identification of a novel endothelial-derived gene EG-1". Biochemical and Biophysical Research Communications. 290 (1): 602–12. doi:10.1006/bbrc.2001.6119. PMID 11779215.
  2. ↑ 2.0 2.1 2.2 Wiederhold T, Lee MF, James M, Neujahr R, Smith N, Murthy A, Hartwig J, Gusella JF, Ramesh V (Nov 2004). "Magicin, a novel cytoskeletal protein associates with the NF2 tumor suppressor merlin and Grb2". Oncogene. 23 (54): 8815–25. doi:10.1038/sj.onc.1208110. PMID 15467741.
  3. ↑ "Entrez Gene: MED28 mediator of RNA polymerase II transcription, subunit 28 homolog (S. cerevisiae)".
  4. ↑ Beyer KS, Beauchamp RL, Lee MF, Gusella JF, Näär AM, Ramesh V (Nov 2007). "Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation". The Journal of Biological Chemistry. 282 (44): 32152–7. doi:10.1074/jbc.M706592200. PMID 17848560.
  5. ↑ Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC (Jun 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular Cell. 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
This article incorporates text from the public domain Pfam and InterPro: IPR021640

Further reading

  • Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y (Oct 2001). "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research. 11 (10): 1758–65. doi:10.1101/gr.180101. PMC 311163. PMID 11591653.
  • Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW (Apr 2003). "Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3". The Journal of Biological Chemistry. 278 (17): 15123–7. doi:10.1074/jbc.C300054200. PMID 12584197.
  • Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW (Feb 2004). "A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2". The Journal of Biological Chemistry. 279 (7): 5846–51. doi:10.1074/jbc.M312523200. PMID 14638676.
  • Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC (Jun 2004). "A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology". Molecular Cell. 14 (5): 685–91. doi:10.1016/j.molcel.2004.05.006. PMID 15175163.
  • Lu M, Zhang L, Maul RS, Sartippour MR, Norris A, Whitelegge J, Rao JY, Brooks MN (Jul 2005). "The novel gene EG-1 stimulates cellular proliferation". Cancer Research. 65 (14): 6159–66. doi:10.1158/0008-5472.CAN-04-4016. PMID 16024617.
  • Lee MF, Beauchamp RL, Beyer KS, Gusella JF, Ramesh V (Sep 2006). "Magicin associates with the Src-family kinases and is phosphorylated upon CD3 stimulation". Biochemical and Biophysical Research Communications. 348 (3): 826–31. doi:10.1016/j.bbrc.2006.07.126. PMID 16899217.
  • Lu M, Zhang L, Sartippour MR, Norris AJ, Brooks MN (Oct 2006). "EG-1 interacts with c-Src and activates its signaling pathway". International Journal of Oncology. 29 (4): 1013–8. doi:10.3892/ijo.29.4.1013. PMID 16964398.
  • Beyer KS, Beauchamp RL, Lee MF, Gusella JF, Näär AM, Ramesh V (Nov 2007). "Mediator subunit MED28 (Magicin) is a repressor of smooth muscle cell differentiation". The Journal of Biological Chemistry. 282 (44): 32152–7. doi:10.1074/jbc.M706592200. PMID 17848560.


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