Lipoprotein disorders classification

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Template:DiseaseDisorder infobox

Lipoprotein Disorders Microchapters

Patient Information

Overview

Causes

Classification

Hyperlipoproteinemia
Hypolipoproteinemia

Treatment

Overview

Hyperlipidemias are classified according to the Fredrickson classification which is based on the pattern of lipoproteins on electrophoresis or ultracentrifugation.[1] It was later adopted by the World Health Organization (WHO). It does not directly account for HDL, and it does not distinguish among the different genes that may be partially responsible for some of these conditions. It remains a popular system of classification, but is considered dated by many.

Classification

Fredrickson classification of Hyperlipidemias
Hyperlipoproteinemia Synonyms Problems Labs description Treatment
Type I Buerger-Gruetz syndrome, Primary hyperlipoproteinaemia, or Familial hyperchylomicronemia Decreased lipoprotein lipase (LPL) or altered ApoC2 Elevated Chylomicrons Diet Control
Type IIa Polygenic hypercholesterolaemia or Familial hypercholesterolemia LDL receptor deficiency Elevated LDL only Bile Acid Sequestrants, Statins, Niacin
Type IIb Combined hyperlipidemia Decreased LDL receptor and Increased ApoB Elevated LDL, VLDL and Triglycerides Statins, Niacin, Gemfibrozil
Type III Familial Dysbetalipoproteinemia Defect in ApoE synthesis Increased IDL Drug of choice: Gemfibrozil
Type IV Endogenous Hyperlipemia Increased VLDL production and Decreased elimination Increased VLDL Drug of choice: Niacin
Type V Familial Hypertriglyceridemia Increased VLDL production and Decreased LPL Increased VLDL and Chylomicrons Niacin, Gemfibrozil

Unclassified forms

Non-classified forms are extremely rare:

  • Hypo-alpha lipoproteinemia
  • Hypo-beta lipoproteinemia (prevalence 0.01-0.1%)

References

  1. Frederickson DS, Lee RS. A system for phenotyping hyperlipidemia. Circulation 1965;31:321-7. PMID 14262568.

External links

Hyperlipoproteinemia OMIM GPnotebook WebMD Others
Type I Online Mendelian Inheritance in Man (OMIM) 238600 Template:GPnotebook . MeritCare
Type IIa Online Mendelian Inheritance in Man (OMIM) 144400 Template:GPnotebook . Merck
Type IIb Template:GPnotebook .
Type III . Template:GPnotebook WebMD Yahoo
Type IV Online Mendelian Inheritance in Man (OMIM) 144600 Template:GPnotebook WebMD Yahoo
Type V Online Mendelian Inheritance in Man (OMIM) 144600 Template:GPnotebook . .

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