Combined hyperlipidemia

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Media

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Videos on Combined hyperlipidemia

Evidence Based Medicine

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TRIP on Combined hyperlipidemia

Clinical Trials

Ongoing Trials on Combined hyperlipidemia at Clinical Trials.gov

Trial results on Combined hyperlipidemia

Clinical Trials on Combined hyperlipidemia at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Combined hyperlipidemia

NICE Guidance on Combined hyperlipidemia

NHS PRODIGY Guidance

FDA on Combined hyperlipidemia

CDC on Combined hyperlipidemia

Books

Books on Combined hyperlipidemia

News

Combined hyperlipidemia in the news

Be alerted to news on Combined hyperlipidemia

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Blogs on Combined hyperlipidemia

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Definitions of Combined hyperlipidemia

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Patient resources on Combined hyperlipidemia

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Patient Handouts on Combined hyperlipidemia

Directions to Hospitals Treating Combined hyperlipidemia

Risk calculators and risk factors for Combined hyperlipidemia

Healthcare Provider Resources

Symptoms of Combined hyperlipidemia

Causes & Risk Factors for Combined hyperlipidemia

Diagnostic studies for Combined hyperlipidemia

Treatment of Combined hyperlipidemia

Continuing Medical Education (CME)

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Combined hyperlipidemia en Espanol

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Experimental / Informatics

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]


In medicine, combined hyperlipidemia (or -aemia) is a commonly occurring form of hypercholesterolemia (elevated cholesterol levels) characterised by increased LDL and triglyceride concentrations, often accompanied by decreased HDL. On lipoprotein electrophoresis (a test now rarely performed) it shows as a hyperlipoproteinemia type IIB.

The elevated triglyceride levels (>5 mmol/l) are generally due to an increase in VLDL (very low density lipoprotein), a class of lipoprotein that is prone to cause atherosclerosis.

Types

There are roughly two forms of this lipid disorder:

Treatment

Both conditions are treated with fibrate drugs, which act on the peroxisome proliferator-activated receptors (PPARs), specifically PPARα, to decrease free fatty acid production.

Statin drugs, especially the synthetic statins (atorvastatin and rosuvastatin) can decrease LDL levels by increasing hepatic reuptake of LDL due to increased LDL-receptor expression.

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